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  4. Recombinant Mouse TBC1 domain family member 24 (Tbc1d24)

Recombinant Mouse TBC1 domain family member 24 (Tbc1d24)

  • 中文名稱：
    小鼠Tbc1d24重組蛋白
  • 貨號：
    CSB-YP659751MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tbc1d24重組蛋白
  • 貨號：
    CSB-EP659751MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tbc1d24重組蛋白
  • 貨號：
    CSB-EP659751MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tbc1d24重組蛋白
  • 貨號：
    CSB-BP659751MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tbc1d24重組蛋白
  • 貨號：
    CSB-MP659751MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbc1d24
  • Uniprot No.：
  • 別名：
    Tbc1d24; Kiaa1171; TBC1 domain family member 24
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-561
  • 氨基酸序列
    MDPPGYNCFV DKDKMDASIQ DLGPKELNCT ELQELKQLAR QGYWAQSHTL RGKVYQRLIR DIPCRTVTPD ASVYSDIVGK IVGKHSSSSL PLPEFVDNTQ VPTYCLNTRG EGAVRKILLC IANQFPDISF CPALPAVVAL LLHYSIDEAE CFEKACRILS CNDPTKKLID QSFLAFESSC MTFGDLVNKY CQAAHKLMVA VSEDVLQVYS DWQRWLFGEL PLNYFARVFD VFLVEGYKVL YRVALAILKF FHKVRAGQPL ESDNVKQDIR MFVKDIAKTV SPEKLLEKAF AIRLFSRKEI QLLQMANEKA LRQKGITVKQ KSVSLSKRQF VHLAVHAENF HSEIVSVKEM RDIWSWIPER FALCQPLLLF SSLQHGYSLS RFYFQCEGHE PTLLLIKTTQ KEVCGAYLST DWSERTKFGG KLGFFGTGEC FVFRLQPEVQ RYEWVVIKHP ELTKATSLKS SEAAGSSSLI SHCSSDPADR LSPFLAARHF NLPSKTESMF MAGGNDCLII GGGGGQALYV DGDLNRGRTG HCDTFNNQPL CSENFLIAAV EAWGFQDPDT E
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking.
  • 基因功能參考文獻：
    1. that the p.Ser178Leu mutation of TBC1D24 is a probable cause for dominant, nonsyndromic hearing impairment. Identification of TBC1D24 as the stereocilia-expressing gene may shed new light on its specific function in the inner ear. PMID: 24729547
    2. Two compound heterozygous missense mutations (D147H and A509V) in TBC1D24, a gene of unknown function, are responsible for familial infantile myoclonic epilepsy. PMID: 20727515
    3. A pathogenic mutation was identified in TBC1D24. PMID: 20797691
  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasmic vesicle membrane. Cell junction, synapse, presynapse.
  • 組織特異性：
    Expressed in brain, particularly at the level of the cortex and the hippocampus. Expressed in the inner ear in spiral ganglion cells, a collection of neurons critical for hearing and balance.
  • 數據庫鏈接：


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