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  4. Recombinant Mouse Secretin (Sct)

Recombinant Mouse Secretin (Sct)

  • 中文名稱：
    小鼠Sct重組蛋白
  • 貨號：
    CSB-YP600871MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Sct重組蛋白
  • 貨號：
    CSB-EP600871MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Sct重組蛋白
  • 貨號：
    CSB-EP600871MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Sct重組蛋白
  • 貨號：
    CSB-BP600871MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Sct重組蛋白
  • 貨號：
    CSB-MP600871MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Sct
  • Uniprot No.：
  • 別名：
    Sct; Secretin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Cytoplasmic domain
  • 表達區域：
    32-58
  • 氨基酸序列
    HSDGMFTSE LSRLQDSARL QRLLQGLV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis. Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance.
  • 基因功能參考文獻：
    1. The increased calcium response mediated by secretin in the absence of GLP-1R was paralleled by an increased glucose-dependent insulin response, indicating that the heterodimeric receptor complexes modulate secretin responses. PMID: 28368447
    2. Study demonstrates that secretin-induced dendritic oxytocin release from supraoptic neurons enhances social recognition. The newly defined secretin-oxytocin system may lead to a possible treatment for social deficits. PMID: 26803341
    3. Secretin expression is not detected under delayed implantation but is stimulated after estrogen activation and under artificial decidualization. PMID: 24336673
    4. Results suggest a role in motor coordination and motor learning for SCT expressed in cerebellar Purkinje cells PMID: 24356714
    5. a novel positive feedback pathway involving secretin and CD36 to enhance intestinal lipid absorption is being proposed. PMID: 24769669
    6. in vitro lipolytic effects of Sct PMID: 24273196
    7. CD36 is a major mediator of FA-induced release of CCK and secretin. These peptides contribute to the role of CD36 in fat absorption and to its pleiotropic metabolic effects. PMID: 23233532
    8. a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin PMID: 23064014
    9. The characteristics of Secretin fit the paradigm of known placental hormones and suggest that it may play an important role during pregnancy. PMID: 21944867
    10. secretin is not required for normal pancreatic development or adaptive growth mediated by CCK. PMID: 21852360
    11. Immunohistochemical staining of the arcuate nucleus shows colocalization of Sct receptors with proopiomelanocortin that provide anatomical evidence for a possible anorectic role of Sct. PMID: 20927047
    12. Findings identify SCT and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body. PMID: 20739612
    13. Secretin expression is present in several developing brain regions such as cephalic mesenchyme, cerebellar primordium & choroid plexus as well as epithelial villi lining & inner circular muscle of developing intestine in mouse embryos. PMID: 15661652
    14. small heterodimer partner and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway PMID: 16888194
    15. These findings suggest that secretin is involved in synaptic function in the adult brain. PMID: 18534766
    16. results suggest that secretin signal plays a neuroprotective role of neuronal progenitor cells against the neurotoxicity of ethanol PMID: 19349917
    17. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). PMID: 19372104

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Glucagon family
  • 組織特異性：
    Highly expressed in the intestine. Also expressed in the hippocampus, cerebellum and the brain stem in adult mouse brain. In the hippocampus, expressed in the dentate gyrus, the hilus and the molecular layer.
  • 數據庫鏈接：

    KEGG: mmu:20287

    STRING: 10090.ENSMUSP00000128729

    UniGene: Mm.4723



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