在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Run domain Beclin-1 interacting and cystein-rich containing protein (Kiaa0226), partial

Recombinant Mouse Run domain Beclin-1 interacting and cystein-rich containing protein (Kiaa0226), partial

  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-YP767318MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-EP767318MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-EP767318MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-BP767318MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-MP767318MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rubcn; Kiaa0226; Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Rubicon
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation.; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes.
  • 基因功能參考文獻(xiàn)：
    1. Rubicon specifically interacts with the interferon regulatory factor (IRF) association domain (IAD) of IRF3, and this interaction leads to inhibition of the dimerization of IRF3, which negatively regulates interferon-mediated antiviral response. PMID: 28468885
    2. Rubicon deficiency enhances autophagic flux in the heart and protects mice from lethality and reduction in stroke volume induced by LPS. PMID: 25502307
    3. Data indicate that Rubicon (Kiaa0226) and NOX2 (gp91phox) are involved in microtubule-associated protein LC3-associated phagocytosis. PMID: 26098576
    4. Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps. PMID: 19270693
    5. Two Beclin 1 associated proteins, Atg14L and Rubicon, were identified. PMID: 19270696

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 亚洲欧洲免费三级网站| 老司机深夜18禁污污网站| 极品少妇被啪到呻吟喷水| 国产三级在线观看播放| 丰满的少妇xxxxx人| 全部孕妇毛片| 好吊色欧美一区二区三区视频| 伊人久久大香线蕉成人| 午夜三级a三级三点| 熟妇人妻午夜寂寞影院| 色偷偷88888欧美精品久久久| 国产精品丰臀| 国产精品爽爽va吃奶在线观看| 99精品丰满人妻无码a片| 亚洲精品无码mv在线观看| 欧美疯狂做受xxxxx高潮| 美女大量吞精在线观看456| 亚洲性无码av在线dvd| 日韩欧美亚洲中文乱码| 久久国产乱子伦精品免费女人| 国产精品国产成人国产三级| 色 亚洲 日韩 国产 综合| 日韩av无码免费播放| 中文字幕有码无码av| 无码人妻专区免费视频| 亚洲国产精品av在线播放| 亚洲2021av天堂手机版| 很黄很色60分钟在线观看| 亚洲a综合一区二区三区| 国产极品美女到高潮无套| 亚洲国产精品综合久久网各| 天天爽夜夜爽人人爽一区二区| 国产三级视频在线观看视| 人妻天天爽夜夜爽精品视频| 午夜在线a亚洲v天堂网2018 | 中文乱码字幕视频观看网站免费| 老湿机69福利区无码| 大肉大捧一进一出好爽视频| 欧美日本韩国亚洲| av人摸人人人澡人人超碰下载| 久久天天躁狠狠躁夜夜躁app|