在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Run domain Beclin-1 interacting and cystein-rich containing protein (Kiaa0226), partial

Recombinant Mouse Run domain Beclin-1 interacting and cystein-rich containing protein (Kiaa0226), partial

  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-YP767318MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-EP767318MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-EP767318MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-BP767318MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rubcn重組蛋白
  • 貨號(hào)：
    CSB-MP767318MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rubcn; Kiaa0226; Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Rubicon
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation.; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes.
  • 基因功能參考文獻(xiàn)：
    1. Rubicon specifically interacts with the interferon regulatory factor (IRF) association domain (IAD) of IRF3, and this interaction leads to inhibition of the dimerization of IRF3, which negatively regulates interferon-mediated antiviral response. PMID: 28468885
    2. Rubicon deficiency enhances autophagic flux in the heart and protects mice from lethality and reduction in stroke volume induced by LPS. PMID: 25502307
    3. Data indicate that Rubicon (Kiaa0226) and NOX2 (gp91phox) are involved in microtubule-associated protein LC3-associated phagocytosis. PMID: 26098576
    4. Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps. PMID: 19270693
    5. Two Beclin 1 associated proteins, Atg14L and Rubicon, were identified. PMID: 19270696

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 麻豆国产成人av高清在线| 亚洲精品蜜夜内射| 丰满人妻熟妇乱又伦精品视| 国产欧美精品一区二区三区-老狼| 久艹视频免费看| 亚洲成a∨人片在无码2023| 暖暖视频 免费 日本社区| 69堂人成无码免费视频果冻传媒| 国产aⅴ夜夜欢一区二区三区| 国产精品宾馆在线精品酒店| 国产精品人妻| 日本孕妇潮喷高潮视频| 亚洲欧美综合成人五月天网站| 精品丝袜国产自在线拍小草| 亚洲熟妇色xxxxx欧美老妇y| xx性欧美肥妇精品久久久久久| 亚无码乱人伦一区二区| а√天堂www在线а√天堂资源| 日韩欧美国产一区精品| 超薄丝袜足j好爽在线| 成人免费区一区二区三区 | 人人做人人爽国产视| 免费国产午夜视频在线观看| 真人床震高潮全部视频免费| 国产精品爽爽久久久久久 | 黑人狠狠的挺身进入| 欧美极品色午夜在线视频| 国精一二二产品无人区免费应用| 一本色道无码不卡在线观看| 国产成人无码免费视频在线| 天堂在/线中文在线资源 官网| 最新777第四色米奇影视| 性欧美丰满熟妇xxxx性仙踪林| 曰韩免费无码av一区二区| 99久久国产露脸精品国产麻豆| 日本一丰满一bbw| 无码成人一区二区| 精品国产午夜肉伦伦影院| 亚洲欧洲成人a∨在线观看| 国产 国语对白 露脸| 最大胆裸体人体牲交|