在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Regenerating islet-derived protein 3-beta (Reg3b)

In Stock
  • 中文名稱:
    小鼠Reg3b重組蛋白
  • 貨號:
    CSB-EP333982MO
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    Reg3b
  • Uniprot No.:
  • 別名:
    REG-3-beta;Pancreatitis-associated protein 1;Regenerating islet-derived protein III-beta;Reg III-beta
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    28.4 kDa
  • 表達區域:
    38-175aa
  • 氨基酸序列
    ISCPKGSQAYGSYCYALFQIPQTWFDAELACQKRPGGHLVSVLNSAEASFLSSMVKRTGNSYQYTWIGLHDPTLGAEPNGGGWEWSNNDVMNYFNWERNPSTALDRAFCGSLSRASGFLKWRDMTCEVKLPYVCKFTG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.
  • 基因功能參考文獻:
    1. Reg3beta is a prognostic biomarker for acute coronary syndrome and is strongly associated with the intensity of cardiac inflammation. PMID: 29544958
    2. The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas. PMID: 28415799
    3. BMI1 and MEL18 contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. PMID: 28780076
    4. Intestinal deficiency in REG3B or REG3G increases numbers of mucosa-associated bacteria and enhances bacterial translocation to the mesenteric lymph nodes and liver. PMID: 26867181
    5. our findings reveal a dual and contextual pathophysiologic role for REG3beta during pancreatitis and pancreatic ductal adenocarcinoma initiation PMID: 26404002
    6. our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 by a completely "unrelated" regenerating protein, Reg3beta, via transcriptional activation of Scly PMID: 23811004
    7. Reg3beta-dependent accumulation of macrophages in the ischemic heart has a role in myocardial healing PMID: 25751817
    8. High Reg3B expression is associated with pancreatic tumor growth. PMID: 23867474
    9. Direct stimulation of Reg2 and Reg3beta genes by glucocorticoids. PMID: 23147030
    10. Pancreatic STAT3 is indispensable for PAP1 production. PMID: 23064197
    11. Expression of Reg3 proteins and Ang4 by goblet cells point to an important role for goblet cells in innate defense. PMID: 22723890
    12. Reg-IIIbeta is expressed in specific subsets of primary sensory neurons and motor neurons; expression is transient during the embryonic and perinatal periods. PMID: 21681751
    13. Reg3b plays a protective role against intestinal translocation of the gram-negative bacterium Salmonella enteritidis in mice but not against the gram-positive bacterium Listeria monocytogenes. PMID: 22252863
    14. RegIIIbeta production by the host can promote S. Typhimurium infection by eliminating inhibitory gut microbiota. PMID: 21694778
    15. Reg2, Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns. PMID: 21410322
    16. These data are consistent with a pleiotropic role for INGAP and reveal new pathways to target in the discovery of improved diabetic therapies PMID: 21187123
    17. Reg3beta is unlikely an islet growth factor but a putative protector that prevents streptozotocin-induced damage by inducing the expression of specific genes. PMID: 21245462
    18. the expression of the anti-inflammatory protein pancreatitis-associated protein I is enhanced by p8 PMID: 14660681
    19. Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons PMID: 18678917

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Overexpressed during the acute phase of pancreatitis.
  • 亞細胞定位:
    Secreted.
  • 組織特異性:
    Constitutively expressed in the small intestine, moderately in colon and at an extremely low level in healthy pancreas.
  • 數據庫鏈接:


主站蜘蛛池模板: 欧美老熟妇又粗又大| 久久国产av影片| 色欲天天婬色婬香综合网| 亚洲午夜久久久精品影院| 亚洲人成网站色www| 免费人成在线观看视频播放| 亚洲精品乱码久久久久红杏| 三上悠亚的av片在线无码| 中字幕久久久人妻熟女天美传媒| 97久久超碰国产精品旧版麻豆| 无码人妻丰满熟妇奶水区码 | 久在线精品视频线观看| 国产破外女出血视频| 免费无码在线播放av| 国产欧美日本亚洲精品一5区| 国产精品人人妻人人爽人人牛| 日本免费视频| 日韩卡1卡2 卡三卡免费| 成在线人免费视频播放| 中文字幕精品久久久久人妻| 国产一区二区三区成人欧美日韩在线观看| 爱色精品视频一区二区| 五月激情婷婷丁香综合基地| 国产成人精品三级麻豆| 久久久精品国产sm调教网站| 无码国产精品免费看| 丰满人妻无奈张开双腿av| 久久精品伊人一区二区三区| 乌克兰少妇videos高潮| 激情欧美日韩一区二区| 亚洲 自拍 色综合图区av| 亚洲精品无码av中文字幕| 国精产品一二三区精华液| 国产三区在线成人av| 亚洲综合无码无在线观看| 亚洲精品av一区午夜福利| 免费又黄又爽又色的视频| 中年人妻丰满av无码久久不卡| 六十熟妇乱子伦视频| 性xxxx欧美老妇506070| 久久精品人妻少妇一区二区三区|