在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Ras GTPase-activating protein SynGAP (Syngap1), partial

Recombinant Mouse Ras GTPase-activating protein SynGAP (Syngap1), partial

  • 中文名稱：
    小鼠Syngap1重組蛋白
  • 貨號(hào)：
    CSB-YP023010MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Syngap1重組蛋白
  • 貨號(hào)：
    CSB-EP023010MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Syngap1重組蛋白
  • 貨號(hào)：
    CSB-EP023010MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Syngap1重組蛋白
  • 貨號(hào)：
    CSB-BP023010MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Syngap1重組蛋白
  • 貨號(hào)：
    CSB-MP023010MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Syngap1; Ras/Rap GTPase-activating protein SynGAP; Neuronal RasGAP; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
  • 基因功能參考文獻(xiàn)：
    1. Study results indicate that Syngap1 plays a critical role in GABAergic circuit function and further suggest that Syngap1 haploinsufficiency in GABAergic circuits may contribute to cognitive deficits. PMID: 27827368
    2. The authors present evidence that synGAP-alpha1 regulates the composition of the postsynaptic density by restricting binding to the PDZ domains of PSD-95. PMID: 27623146
    3. Study found that Syngap1 mutations associated with developmental brain disorders disrupt a critical period of neuronal growth, maturation, and dynamics of dendritic structures known to influence de novo assembly of developing cortical circuits PMID: 25444158
    4. inactivation of a single copy of syngap1 induced widespread early functional maturation of excitatory connections in the mouse neocortex PMID: 23785156
    5. These data demonstrate that SynGAP protein acts as a critical developmental repressor of neural excitability that promotes the development of life-long cognitive abilities. PMID: 23141534
    6. This study demonstrated the functional significance of SynGAP1 signaling in the adult brain by capturing several changes that are dependent on NMDAR and hippocampal integrity. PMID: 22700469
    7. Overexpression of SynGAP alpha1 versus alpha2 C-termini-containing proteins in hippocampal neurons has opposing effects on synaptic strength, decreasing and increasing miniature excitatory synaptic currents amplitude/frequency, respectively. PMID: 22692543
    8. SynGAP is an important regulator of the release of the neuropeptide calcitonin gene-related peptide from primary sensory neurons and can modulate capsaicin-induced hypernociception. PMID: 21525372
    9. Data show that deletion of SynGAP is associated with notable behavioral as well as morphological phenotypes indicative of hippocampal dysfunction. PMID: 20105235
    10. The GAP activity of synGAP and its association with PSD-95 are important for normal regulation of spine and synapse formation in hippocampal neurons. PMID: 15470153
    11. SynGAP expression peaked at times of synaptogenesis and developmental plasticity and SynGAP showed a more spatially restricted pattern as illustrated by its restriction to forebrain PMID: 15673435
    12. The level of synGAP protein measured at 2 and 8 weeks after birth indicates that neuronal apoptosis is enhanced by reduction of synGAP in conditional mice mutants. PMID: 15733080
    13. SynGAP, a synaptic Ras GTPase activating protein, is essential for the anatomical development of whisker-related patterns in the developing somatosensory pathways in rodent forebrain. PMID: 16452659
    14. SynGAP plays a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission. PMID: 16537406
    15. synGAP mediates a rate-limiting step in steady-state regulation of spine morphology PMID: 19074040
    16. The syngap mutant mice displayed a complete lack of social memory and SynGAP mutants had deficits in cued fear conditioning and working memory, indicating abnormal function of circuits that control emotion and choice. PMID: 19145222
    17. constitutive SynGAP reduction increases vigor in the execution of learned operant behavior without compromising its temporal control, yielding effects readily distinguishable from NMDAR blockade. PMID: 19824778

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Membrane; Peripheral membrane protein. Cell junction, synapse.
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 国产精品对白刺激久久久| 动漫av纯肉无码免费播放| 99热这里只有是精品2| 国内自拍久久久久影院| 在线观看老湿视频福利| 亚洲精品无码久久久久| 最新的国产成人精品2021| 午夜成人性刺激免费视频 | 午夜理论片yy6080私人影院| 欧美成人精品手机在线| 欧洲熟妇色xxxxx视频| 丰满人妻无奈张开双腿av| 国产麻传媒精品国产av| 18禁黄无遮挡网站| 宅男宅女精品国产av天堂| 亚洲精品午夜一区二区电影院 | 国産精品久久久久久久| 天干夜啦天干天干国产免费| 18禁无遮挡肉动漫在线播放观看| 中文字幕精品一二三四五六七八| 精品国产18久久久久久| 伊在人天堂亚洲香蕉精品区| 热re99久久6国产精品免费| 无码精品黑人一区二区三区| 大陆极品少妇内射aaaaaa| 国产欧美久久一区二区三区| 色综合网天天综合色中文| 亚洲一本一道一区二区三区| 日日摸天天爽天天爽视频| 日本久久久久久久做爰片日本| 亚洲va天堂va欧美片a在线| 亚洲精品久久av无码麻| 9色国产深夜内射| 国产a√精品区二区三区四区| 日韩精品亚洲人旧成在线| 午夜成人无码福利免费视频| 中文字幕无码不卡一区二区三区| 亚洲欧洲无码av不卡在线| 亚洲欧美日韩中文在线制服| 97人妻精品一区二区三区| 人妻丝袜av先锋影音先|