在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Protein cereblon (Crbn)

  • 中文名稱:
    Recombinant Mouse Protein cereblon(Crbn)
  • 貨號:
    CSB-YP806030MO
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    CrbnProtein cereblon; Protein PiL
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    54.9kDa
  • 表達區(qū)域:
    1-445aa
  • 氨基酸序列
    MAGEGDQQDAAHNMGNHLPLLPADSEDEDDEIEMEVEDQDSKEARKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPEVLMILIPGQTLPLQLSHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQEFGIEVVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQVFPSKPISWEDQYSCKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPENPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPETEDEISPDKVILCL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently, cognitive functions such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.
  • 基因功能參考文獻:
    1. Collectively, our data suggested that CRBN is a potential treatment option against diabetes-induced osteolytic bone disease. PMID: 29353038
    2. Data show that cereblon (CRBN) limits CD4(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (Kv1.3) expression. PMID: 27439875
    3. CRBN negatively regulates TLR4 signaling via attenuation of TRAF6 and TAB2 ubiquitination. PMID: 27468689
    4. CRBN is involved in the activation of PERK and the Ire1 pathway of the unfolded protein response.CRBN plays a role in cellular stress signaling, including the unfolded protein response, by controlling the activity of AMPK. PMID: 25619137
    5. results of this study suggest a plausible mechanism for CRBN involvement in higher brain function in humans, and they may help explain how a specific mutation in CRBN can affect the cognitive ability of patients PMID: 24993823
    6. Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice. PMID: 24755080
    7. findings suggest that crbn-/- mice exhibit selective HPC-dependent deficits in associative learning. PMID: 21995942
    8. CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK alpha1) and inhibits the activation of AMPK activation. PMID: 21232561
    9. These results imply that Nrf2 stimulates CRBN gene transcription under hypoxia-reoxygenation conditions in neuronal cells. PMID: 20691658

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    CRBN family
  • 組織特異性:
    Highly expressed in brain.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 久久伊99综合婷婷久久伊| 人妻丰满av无码中文字幕| 日本亲子乱子伦xxxx50路| 国产精品高潮呻吟av久久男男| 国产欧美日韩中文久久| 国产麻豆剧传媒精品国产av| 丰满少妇弄高潮了www| 国产精品亚洲成在人线| 亚洲另类欧美小说图片区| 亚洲 小说 欧美 另类 社区| 国产女人水真多18毛片18精品| 欧美三根一起进三p| 欧美精品国产aⅴ一区二区在线| 无套熟女av呻吟在线观看| 亚洲欧美综合精品成人导航| 亚洲成aⅴ人片在线观| 97人妻天天摸天天爽天天| 久久久久久av无码免费网站下载| 日本牲交大片免费观看| 伊人无码一区二区三区| 精品无码成人久久久久久| 免费观看全黄做爰大片国产| 女人的精水喷出来视频| 日本高清一二三不卡区| 欧美肥臀大屁股magnet| 国产亚洲精品久久久久丝瓜 | 国产乱了真实在线观看| 99视频国产精品免费观看| 五月综合激情婷婷六月色窝| 无码av无码天堂资源网| 久久国内精品自在自线| 欧美婷婷六月丁香综合| 男人靠女人的免费视频| 人妻互换免费中文字幕| 国产手机在线国内精品| 99久热re在线精品视频| 牛和人交videos欧美| 欧美顶级少妇做爰hd| 国产人妻精品一区二区三区| 午夜精品电影你懂的| 亚洲r成人av久久人人爽|