在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Protein RD3 (Rd3)

  • 中文名稱:
    Recombinant Mouse Protein RD3 (Rd3)
  • 貨號:
    CSB-MP805945MO
  • 規格:
    ¥1740
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    Rd3
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 分子量:
    51.6 kDa
  • 表達區域:
    1-195aa
  • 氨基酸序列
    MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal hFc1-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina.
  • 基因功能參考文獻:
    1. Study describes a mouse model of Leber's Congenital Amaurosis type 1 and 12 with autosomal recessive mutation in rd3 gene. The substitution mutation in the Rd3 gene is predicted to cause a stop codon after residue 106. PMID: 27150101
    2. the main RetGC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(87)-Leu(122) region. PMID: 27471269
    3. Direct association between RD3 and GCAP1 is important for GC1 targeting. PMID: 25477517
    4. Studies indicate that RD3 plays an essential role in the exit of guanylate cyclase from the endoplasmic reticulum and its trafficking to photoreceptor outer segments. PMID: 23740938
    5. Changes in gene expression associated with photoreceptor degeneration in the rd3 mouse model of Leber congenital amaurosis (LCA) type 12, are characterized. PMID: 23687432
    6. photoreceptor degeneration in the rd3 mouse, rcd2 dog, and LCA12 patients is caused by impaired RD3-mediated guanylate cyclase expression and trafficking PMID: 21078983
    7. Rd3 is preferentially expressed in the retina and exhibits increasing expression through early postnatal development. PMID: 17186464

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Endosome. Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
  • 組織特異性:
    Expressed in the retina and in particular in the inner nuclear layer, in rod and cone outer segments, in the outer nuclear layer, in the outer plexiform layer and in the ganglion cell layer.
  • 數據庫鏈接:


主站蜘蛛池模板: 四虎成人国产精品永久在线| 在线播放免费人成毛片试看| 婷婷色综合视频在线观看| 又色又爽又黄高潮的免费视频| 精品无码国产一区二区三区麻豆| 欧美激情精品久久久久久| 亚洲欧洲av一区二区久久| 2019久久久最新精品| 亚洲中文字幕无码不卡电影| 色欲一区二区三区精品a片| 欧美极p品少妇的xxxxx| 加勒比中文无码久久综合色| 4399理论片午午伦夜理片| 色综合视频一区二区三区| 日韩在线视频线观看一区| 让少妇爽到高潮视频| 国产成人拍精品视频午夜网站 | 国产精品无码一区二区在线观一| 97久久精品亚洲中文字幕无码 | 少妇午夜啪爽嗷嗷叫视频| 国产乱子伦三级在线播放| 中文字幕日韩人妻不卡一区| 国产午夜精品av一区二区麻豆| 中文字幕乱码免费看电影| 另类亚洲综合区图片区小说| 日韩精品少妇无码受不了| 水蜜桃亚洲一二三四在线| 曰韩少妇内射免费播放| 国产xxxx色视频在线观看| 99国产精品久久久久久久久久久| 精品少妇人妻av无码久久| 免费看又黄又爽又猛的视频软件| 亚洲中文字幕a∨在线| 亚洲一区二区三区小说| 无码免费一区二区三区免费播放 | 少妇被又大又粗猛烈进出视频| 国产麻豆剧果冻传媒白晶晶| 国产精品美女久久久久久2018| 日本看片一二三区高清| 夜夜爱夜鲁夜鲁很鲁| 成人国产精品一区二区网站公司 |