在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Protein RD3 (Rd3)

  • 中文名稱:
    Recombinant Mouse Protein RD3 (Rd3)
  • 貨號:
    CSB-MP805945MO
  • 規格:
    ¥1740
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    Rd3
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 分子量:
    51.6 kDa
  • 表達區域:
    1-195aa
  • 氨基酸序列
    MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal hFc1-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina.
  • 基因功能參考文獻:
    1. Study describes a mouse model of Leber's Congenital Amaurosis type 1 and 12 with autosomal recessive mutation in rd3 gene. The substitution mutation in the Rd3 gene is predicted to cause a stop codon after residue 106. PMID: 27150101
    2. the main RetGC-binding interface on RD3 required for the negative regulation of the cyclase localizes to the Lys(87)-Leu(122) region. PMID: 27471269
    3. Direct association between RD3 and GCAP1 is important for GC1 targeting. PMID: 25477517
    4. Studies indicate that RD3 plays an essential role in the exit of guanylate cyclase from the endoplasmic reticulum and its trafficking to photoreceptor outer segments. PMID: 23740938
    5. Changes in gene expression associated with photoreceptor degeneration in the rd3 mouse model of Leber congenital amaurosis (LCA) type 12, are characterized. PMID: 23687432
    6. photoreceptor degeneration in the rd3 mouse, rcd2 dog, and LCA12 patients is caused by impaired RD3-mediated guanylate cyclase expression and trafficking PMID: 21078983
    7. Rd3 is preferentially expressed in the retina and exhibits increasing expression through early postnatal development. PMID: 17186464

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Endosome. Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
  • 組織特異性:
    Expressed in the retina and in particular in the inner nuclear layer, in rod and cone outer segments, in the outer nuclear layer, in the outer plexiform layer and in the ganglion cell layer.
  • 數據庫鏈接:


主站蜘蛛池模板: 无码高潮喷吹在线观看| 成人影片麻豆国产影片免费观看| 人妻 日韩精品 中文字幕| 国产精品无码电影在线观看| 亚洲免费网站观看视频| 日本特黄aaaaaa大片| 黑人大荫蒂老太大| 波多野结衣久久一区二区 | 日韩国产成人精品视频| 国产日产精品久久快鸭的功能介绍 | 国语自产拍精品香蕉在线播放| 欲妇荡岳丰满少妇岳| 日本中文字幕乱码免费| 日本va欧美va欧美va精品| 亚洲 日韩 欧美 成人 在线观看| 精品无码中文字幕在线| 综合欧美日韩国产成人| 少妇愉情理伦片bd| 性生交大片免费看| 婷婷六月丁香缴 清| 体验区试看120秒啪啪免费| 中国精学生妹品射精久久| 亚洲成色www久久网站| 久久综合亚洲鲁鲁五月天| 四虎影视无码永久免费| 骚动漫十八禁在线观看| 巨人精品福利官方导航| 伊人久久大香线蕉亚洲| 成人电线在线播放无码 | 亚洲综合色在线观看一区| 自拍偷自拍亚洲精品牛影院 | 拍真实国产伦偷精品| 日日拍夜夜嗷嗷叫国产| 日本中文一二区有码在线| 波多野成人无码精品电影| 国产精品18久久久久久vr| 人人爽人人爽人人片a| 亚洲精品国产成人精品软件 | 无码av中文字幕免费放| 成人无码一区二区三区网站| 亚洲国产av无码精品|