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  4. Recombinant Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hcn3), partial

Recombinant Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hcn3), partial

  • 中文名稱：
    小鼠Hcn3重組蛋白
  • 貨號：
    CSB-YP010218MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Hcn3重組蛋白
  • 貨號：
    CSB-EP010218MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Hcn3重組蛋白
  • 貨號：
    CSB-EP010218MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Hcn3重組蛋白
  • 貨號：
    CSB-BP010218MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Hcn3重組蛋白
  • 貨號：
    CSB-MP010218MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hcn3
  • Uniprot No.：
  • 別名：
    Hcn3; Hac3; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3; Hyperpolarization-activated cation channel 3; HAC-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.
  • 基因功能參考文獻：
    1. KCTD3 is an accessory subunit of native HCN3 complexes PMID: 23382386
    2. HCN3 contributes to the ventricular action potential waveform in the murine heart. PMID: 21903939
    3. functional expression of HCN3 channels in thalamic intergeniculate leaflet neurons is crucial for intrinsic excitability and rhythmic burst firing PMID: 21753018
    4. Although HCN channel function was greatly reduced in MitoPark DA neurons, mRNA levels for the isoforms most prominently expressed in DA-rich midbrain areas (HCN-3 and HCN-1) were similar to those of the control mice. PMID: 21233488
    5. the precise contribution of HCN4 to sinus node function still is unresolved, and in particular the role of HCN4 in human autonomic heart rate response has yet to be established. PMID: 20693575
    6. the distinct expression pattern in conjunction with the unusual biophysical properties implies that HCN3 may play an unique role in the body PMID: 15923185
    7. These data establish HCN3 up-regulation as a novel candidate mechanism that might contribute to the in vivo changes of electrical activity in basal ganglia output neurons of the parkinsonian brain. PMID: 19320057

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel HCN family
  • 組織特異性：
    Detected in hypothalamus, amygdala, olfactory bulb, hippocampus and retina (at protein level). Highly expressed in brain and heart, in particular in ventricle, atrium and in sinoatrial node (SAN). Detected at low levels in skeletal muscle and lung.
  • 數據庫鏈接：


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