在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Paired box protein Pax-4 (Pax4)

Recombinant Mouse Paired box protein Pax-4 (Pax4)

  • 中文名稱：
    小鼠Pax4重組蛋白
  • 貨號：
    CSB-YP017490MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pax4重組蛋白
  • 貨號：
    CSB-EP017490MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pax4重組蛋白
  • 貨號：
    CSB-EP017490MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pax4重組蛋白
  • 貨號：
    CSB-BP017490MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pax4重組蛋白
  • 貨號：
    CSB-MP017490MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pax4
  • Uniprot No.：
  • 別名：
    Pax4; Pax-4; Paired box protein Pax-4
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-349
  • 氨基酸序列
    MQQDGLSSVN QLGGLFVNGR PLPLDTRQQI VQLAIRGMRP CDISRSLKVS NGCVSKILGR YYRTGVLEPK CIGGSKPRLA TPAVVARIAQ LKDEYPALFA WEIQHQLCTE GLCTQDKAPS VSSINRVLRA LQEDQSLHWT QLRSPAVLAP VLPSPHSNCG APRGPHPGTS HRNRTIFSPG QAEALEKEFQ RGQYPDSVAR GKLAAATSLP EDTVRVWFSN RRAKWRRQEK LKWEAQLPGA SQDLTVPKNS PGIISAQQSP GSVPSAALPV LEPLSPSFCQ LCCGTAPGRC SSDTSSQAYL QPYWDCQSLL PVASSSYVEF AWPCLTTHPV HHLIGGPGQV PSTHCSNWP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters.
  • 基因功能參考文獻：
    1. Down-regulation of PAX4 or its target gene encoding the p97/VCP ATPase reduced myofibril disassembly. PMID: 28096335
    2. Ectopic expression of Pax4 in pancreatic delta cells results in beta-like cell neogenesis. PMID: 29025873
    3. The coordinated regulation of distinct cellular pathways particularly related to ER homeostasis by PAX4 not achieved by the mutant variant PAX4R129W alleviates beta cell degeneration and protects against diabetes mellitus. PMID: 26813254
    4. This work establishes the existence of a bona fide PAX4-enriched cell subpopulation nested within pancreatic islets that can expand in periods of increased functional demands, and exhibit improved viability in response to pathophysiological situations. PMID: 26503027
    5. Pax4 expression is not sufficient to transduce pancreatic alpha cells into beta cells. Overexpression of Pax4 in alpha cells may not increase functional beta cell number in diabetic patients PMID: 26183751
    6. Adult glucagon producing cells can be converted into beta-like cells upon Pax4 misexpression. PMID: 23810513
    7. these finding demonstrate that, downstream of Neurog3, the specification of a subset of enteroendocrine subtypes relies on both Arx and Pax4, while others depend only on Arx or Pax4. PMID: 22570716
    8. Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor-kappaB target genes while increasing Bcl-2 levels. PMID: 21521872
    9. Pax4 has a role in facilitating embryonic stem cell differentiation into the pancreatic lineage PMID: 12525695
    10. A2 and E1 elements in endocrine promoters are essential for Pax4 expression PMID: 14648838
    11. activity appears essential for appropriate initiation of beta-cell differentiation PMID: 14729487
    12. Pax4 is an essential regulator of pancreatic beta-cell development [review] PMID: 15650323
    13. Pax-4 and Arx act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation in the pancreas. PMID: 15930104
    14. The higher insulin production with glucose dependent modulation suggests that pax4 expression can drive more mature insulin producing cells. PMID: 17461469
    15. Data further support the notion that Pax4 activity is necessary to establish appropriate patterns of gene expression in endocrine progenitors of the digestive tract. PMID: 18058910
    16. PAX4 gene is not associated with the risk of type 1 diabetes in a Han Chinese sample. PMID: 18617287
    17. The daily changes in Pax4 expression may contribute to daily changes in function in the differentiated retinal photoreceptor. PMID: 19012751
    18. Ectopically expressed Pax4 using different cell-specific promoters demonstrate that Pax4 forces endocrine precursor cells, as well as mature alpha cells, to adopt a beta cell destiny. PMID: 19665969

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 組織特異性：
    Expressed in early pancreas. Later restricted to beta cells. Undetectable in adult islets.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产精品自在拍首页视频8| 成人无码视频在线观看大全| 午夜福利视频极品国产83| 中文字幕一区日韩精品| 精品无码国产污污污免费| 成年免费视频黄网站zxgk| 国产精品白浆在线观看免费 | 国产一区二区三区四区五区加勒比| 久久精品熟女亚州av麻豆| 国语对白嫖老妇胖老太| 一二三四社区在线中文视频| 两个人看的www在线观看| 国产在线看片免费人成视频| 日韩在线看片免费人成视频播放| 久久午夜羞羞影院免费观看| 天堂а√在线最新版中文| 精品少妇无码一区二区三批| 公么大龟弄得我好舒服秀婷视频| 内射毛片内射国产夫妻| 久久不见久久见免费视频6无删减| 中文字幕va一区二区三区 | 国产亚洲精品aaaa片app| 国产熟女出轨做受的叫床声| 99这里有精品视频视频| 人人妻人人澡人人爽人人精品| 五十老熟妇乱子伦免费观看| 久久综合精品国产一区二区三区无码| 嫩草研究院久久久精品| 综合人妻久久一区二区精品| 永久免费的无码中文字幕| 少妇高潮惨叫久久久久电影| 欧美浓毛大泬视频| 青草视频在线播放| 国产最新精品自产在线观看| 最近日本免费观看高清视频| 国产精品vr专区| 亚洲欧美综合精品成人网| 国产精品女丝袜白丝袜| 亚洲精品成人无码中文毛片不卡 | 色欲来吧来吧天天综合网| 亚洲精品午夜国产va久久成人 |