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  4. Recombinant Mouse Osteoclast-associated immunoglobulin-like receptor (Oscar), partial

Recombinant Mouse Osteoclast-associated immunoglobulin-like receptor (Oscar), partial

  • 中文名稱：
    小鼠Oscar重組蛋白
  • 貨號：
    CSB-YP844981MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Oscar重組蛋白
  • 貨號：
    CSB-EP844981MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Oscar重組蛋白
  • 貨號：
    CSB-EP844981MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Oscar重組蛋白
  • 貨號：
    CSB-BP844981MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Oscar重組蛋白
  • 貨號：
    CSB-MP844981MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Oscar; Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; mOSCAR; Ocl178
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
  • 基因功能參考文獻：
    1. OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis PMID: 23817038
    2. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID: 21841309
    3. PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade. PMID: 12695521
    4. the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation PMID: 15184345
    5. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts PMID: 16109714
    6. Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis. PMID: 18762192

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
  • 組織特異性：
    Specifically expressed in preosteoclasts or mature osteoclasts.
  • 數據庫鏈接：


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