在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Mucolipin-1 (Mcoln1), partial

Recombinant Mouse Mucolipin-1 (Mcoln1), partial

  • 中文名稱：
    小鼠Mcoln1重組蛋白
  • 貨號：
    CSB-YP859533MO1
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mcoln1重組蛋白
  • 貨號：
    CSB-EP859533MO1
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mcoln1重組蛋白
  • 貨號：
    CSB-EP859533MO1-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mcoln1重組蛋白
  • 貨號：
    CSB-BP859533MO1
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mcoln1重組蛋白
  • 貨號：
    CSB-MP859533MO1
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Mcoln1; Trpml1; Mucolipin-1; Mucolipidin; Transient receptor potential-mucolipin 1; TRPML1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events. By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels. Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy. Functions as a Fe(2+) permeable channel in late endosomes and lysosomes. Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells.; May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase.
  • 基因功能參考文獻：
    1. stimulation of TRPML1 elevates cytoplasmic calcium levels in retinal pigmented epithelial cells, but this response is reduced by lysosomal accumulation. PMID: 29030399
    2. single-particle electron cryo-microscopy structure of the mouse TRPML1 channel embedded in nanodiscs; combined with mutagenesis analysis, the TRPML1 structure reveals that phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) binds to the N terminus of the channel-distal from the pore-and the helix-turn-helix extension between segments S2 and S3 probably couples ligand binding to pore opening PMID: 29019981
    3. TRPML1 overexpression or treatment with the mTOR activator propranolol also attenuated the amyloid beta-protein (1-42)-inhibited mTOR/S6K signalling pathway and theamyloid beta-protein(1-42)-induced autophagic lysosome reformation -related protein expression levels. PMID: 29131026
    4. It has been proposed that TRPML1 is regulated by pH, Ca2+, and phosphoinositides in a combined manner in order to accommodate the dynamic endocytosis process. PMID: 28936784
    5. Deletion of TRPML1 increases secretory organelle size by fusion with lysosomes. Enhanced exocytosis that was rescued by re-expression of TRPML1 in neurons. PMID: 26682800
    6. Silencing of TRPML1 hindered phagosome fusion with lysosomes. PMID: 26010303
    7. lack of both mucolipins 1 and 3 causes an accelerated mucolipidosis IV-type of vacuolation in enterocytes PMID: 25521295
    8. In the title. PMID: 25491304
    9. These results demonstrate that the PtdIns(3,5)P2-Mcoln1 axis has an important role in ssRNA transportation into lysosomes in DCs. PMID: 25239130
    10. ML1-null mice develop a primary, early-onset muscular dystrophy independent of neural degeneration. Dystrophin-glycoprotein complex and known membrane repair proteins are expressed normally, but membrane resealing was defective in ML1-null muscle fibers. PMID: 25216637
    11. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors. PMID: 23418601
    12. Transfection of CAMs with plasmids containing a full-length TRP-ML1 gene enhanced FasL-induced two-phase Ca2+ release. PMID: 23283937
    13. Loss of Trpml1 causes reduced levels and mislocalization of the gastric proton pump and alters the secretory canaliculi, causing hypochlorhydria and hypergastrinemia. PMID: 21111738
    14. This study describes, for the first time, a defect in macroautophagy in mucolipin-1-deficient mouse neurons. PMID: 20600908
    15. the loss of TRPML1 function results in intracellular chelatable zinc dyshomeostasis. PMID: 20864526
    16. TRPML1 is expressed in the mouse inner ear. PMID: 20095091
    17. Mucolipin-1 functions in the efficient exit of molecules, destined for various cellular organelles, from lysosomal compartments PMID: 18154673
    18. TRPML1 functions as a Fe(2+) permeable channel in late endosomes and lysosomes PMID: 18794901
    19. This neuropathological characterization of the Mcoln1(-/-) mouse provides an important step in understanding how mucolipin 1 loss of function affects the CNS and contributes to mucolipidosis type IV disease. PMID: 19151629
    20. TRPML1 appears to play a novel role in the tissue-specific transcriptional regulation of TRPML2 PMID: 19763610

    顯示更多

    收起更多

  • 亞細胞定位：
    Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, Polycystin subfamily, MCOLN1 sub-subfamily
  • 組織特異性：
    Widely expressed, with the highest expression in brain, liver and kidney.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:94178

    STRING: 10090.ENSMUSP00000004683

    UniGene: Mm.8356



主站蜘蛛池模板： 国产人妻人伦精品1国产盗摄| 国产超碰人人爱被ios解锁| 久久精品国产首页027007| 久久久一本精品99久久精品66直播| 四虎www永久在线精品| 久久久久久人妻精品一区| 一本色道久久88加勒比—综合| 中文字幕无码一区二区免费| 最新高清中文字幕免费mv| 2020国产亚洲美女精品久久久| 别揉我奶头~嗯~啊~一区二区三区| 人妻av无码中文专区久久| 强奷乱码中文字幕熟女一| 97久久香蕉国产线看观看| 国产精品狼人久久久久影院| 国内无遮挡18禁无码网站免费| 久久996re热这里有精品| 天堂а√8在线最新版在线| 久久精品天天中文字幕人妻| 亚洲成aⅴ人片久青草影院| 久久精品网站免费观看| 黑人巨大av在线播放无码| 久久人妻av无码中文专区| 亚洲精品久久久久久中文字幕| 国产色诱视频在线观看| 免费三级现频在线观看播放| 在线日韩av免费永久观看| 成人无码影片精品久久久| 国产又色又爽又黄的| 久久www免费人成人片| 午夜人妻理论片天堂影院 | 极品少妇被猛的白浆直喷白浆| 国内老熟妇对白xxxxhd| 精品久久久久久亚洲精品| 久久久亚洲欧洲日产国码二区| 国产欧美日韩va另类在线播放| 亚洲熟女乱色综合亚洲图片| 国产成人综合久久三区| 成人网站色52色在线观看| 国产女人抽搐喷浆视频| 桃花色综合影院|