在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Meiotic recombination protein REC8 homolog (Rec8)

Recombinant Mouse Meiotic recombination protein REC8 homolog (Rec8)

  • 中文名稱：
    小鼠Rec8重組蛋白
  • 貨號：
    CSB-YP806492MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Rec8重組蛋白
  • 貨號：
    CSB-EP806492MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Rec8重組蛋白
  • 貨號：
    CSB-EP806492MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Rec8重組蛋白
  • 貨號：
    CSB-BP806492MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Rec8重組蛋白
  • 貨號：
    CSB-MP806492MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Rec8
  • Uniprot No.：
  • 別名：
    Rec8; Mei8; Rec8L1; Meiotic recombination protein REC8 homolog; Cohesin Rec8p
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-591
  • 氨基酸序列
    MFYYPNVLQR HTGCFATIWL AATRGSRLVK REYLNVNVVK TCEEILNYVL VRVQPPVAGL PRPRFSLYLS AQLQIGVIRV YFQQCQYLVE DIQHILEHLH RAQLRIRIDM EEADLPSLLL PNCLAMMETL EDAPEPFFGK MSVDPRLPSP FDIPQIRHLL EAATPEKTRK ETLPEATPDP RKPDRTLATV QSPEVITLQE AEPIRMLQIE GEQDLPEISR GDLELLIAEK DDAILLEERQ RGRLLRQRRA SLPLDESREE PRALEGAGLV SALSPPAPAQ VEGIQEALPG QVFPPEVQKM TGWEPGALLT EVTPPQELRL PAPPSTEKRL PSLQRPLPRR HRRRQLLFWD KETQISREKF EEQLQTGAHC WEYPVAQPPK RMLTSPAELF RTPTLSGWLP PELLGLWTHC AQVPQRMLRQ RPQLETEETV EEERAADEEE RRKTEALSEI EVLREAQEPS GPLMLSSELS LEAAEDEKSR TSLIPPEWWA WSEEGQPEPP ALPMLPELPE VPMEMPPRPE LSSEAVLRAV ALKLQANKEL DFSSLVPPLS PRKLASRVFY LLLVLSTQKI LLVEQQKPYG PLLIRPGPKF P
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
  • 基因功能參考文獻：
    1. REC8-containing cohesin complexes provide canonical SCC, not RAD21 or RAD21L, at the prophase stage of meiosis I in spermatocytes. PMID: 27170622
    2. Rec8 establishes cohesion when activated during DNA replication in fetal oocytes using tamoxifen-inducible Cre. In contrast, no new cohesion is detected when Rec8 is activated in arrested oocytes by tamoxifen despite cohesin synthesis. PMID: 26898469
    3. Plk1 activity is required for meiotic spindle assembly and REC8 cleavage, with pPlk1Ser137 being the action executor, in mouse oocytes during meiotic division. PMID: 26654596
    4. effects ofAte1ablation are inferred to be caused, at least in part, by the failure to destroy the C-terminal fragment of Rec8 in the absence of N-terminal arginylation. PMID: 26858254
    5. Findings indicate that cohesin-mediated long-range interactions facilitate discrete gene expression states within preexisting chromosomal compartments. PMID: 24002784
    6. Data show that nociceptin induces Rec8 phosphorylation, triggering chromosome dynamics, in spermatocytes during meiosis in postnatal testes. PMID: 23720425
    7. We report here evidence from the mouse that partial loss of gene function for either Smc1b or Rec8 causes perturbations in the formation of the synaptonemal complex (SC) and affects both synapsis and recombination between homologs during meiotic prophase PMID: 23408896
    8. show that spermatocytes from mice lacking the two meiosis-specific cohesin subunits RAD21L and REC8 were unable to initiate RAD51- but not DMC1-mediated double-strand break repair PMID: 22711701
    9. Separase is regulated by two independent mechanisms in meiosis I, binding to securin and inhibitory phosphorylation by CDK1; both must be disrupted to have any effect on either chromosome-associated REC8 levels or premature chromosome separation. PMID: 21865557
    10. Rec8 cleavage triggers chiasmata resolution during meiosis I and sister centromere disjunction during meiosis II PMID: 20971813
    11. Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice. PMID: 12130806
    12. Rec8 protein, in association with SMC3 and SMC1beta but not SMC1alpha, is involved in meiosis-specific chromosome behavior; homologous chromosome separation is triggered by selective loss of Rec8 from chromosome arms in meiosis I. PMID: 12759374
    13. a major role for REC8 in mammalian meiosis is to limit synapsis to between homologous chromosomes. PMID: 15935783
    14. Proteolytic activity of separase is therefore essential for Rec8's removal from chromosome arms and for chiasma resolution but not for PBE. PMID: 16839882
    15. loss of armRec8 (homolog separation) and cytokinesis are suppressed until anaphase I by Securin PMID: 16855401

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome. Chromosome, centromere.
  • 蛋白家族：
    Rad21 family
  • 組織特異性：
    Expressed primarily in the gonads. In the testis, expressed in pachytene spermatocytes and in spermatids. Not expressed in spermatogonia or somatic cells. In the ovary, expressed only in oocytes. Low levels also detected in a number of somatic tissues inc
  • 數據庫鏈接：


主站蜘蛛池模板： 亚欧日韩欧美网站在线看| 加勒比东京热无码一区| 印度女人狂野牲交| 无码熟妇αⅴ人妻又粗又大| 性欧美大胆免费播放| 国产乱人伦偷精品视频| 日韩av无码久久一区二区| 精品麻豆丝袜高跟鞋av| 免费又黄又裸乳的视频| 在线精品视频一区二区| 亚洲无人区午夜福利码高清完整版| 特级毛片全部免费播放| 无码人妻av一区二区三区波多野| 久久精品国产清自在天天线 | 无码国产精品一区二区色情男同| 狠狠躁夜夜躁人人爽天天不卡| 国产精品青青在线观看爽香蕉| 国产在线高清理伦片a| 宅男色影视亚洲人在线| 亚洲a∨无码一区二区三区| 天天躁日日躁狠狠躁av| 精品一区二区三区东京热| 国产精品一区二区香蕉| 欧美性video高清精品| 国产av无码专区影视| 一本大道东京热无码一区| 美女张开腿让男人桶爽| 高清破外女出血av毛片| 美女被啪到深处抽搐视频 | 国产久热精品无码激情 | 亚洲国产精品成人无码区| 波多野结衣av一区二区全免费观看| 亚洲经典国产精华液单品榜| 成在人线av无码免费看网站直播| 人妻av无码专区| 久久久久成人精品免费播放动漫| 精产国品一二三产区蘑菇视频| 七妺福利精品导航大全| 精品人妻系列无码专区久久| 中文字幕精品亚洲无线码一区 | 久久99er精品国产首页|