在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Latent-transforming growth factor beta-binding protein 1 (Ltbp1), partial

Recombinant Mouse Latent-transforming growth factor beta-binding protein 1 (Ltbp1), partial

  • 中文名稱：
    小鼠Ltbp1重組蛋白
  • 貨號(hào)：
    CSB-YP807018MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ltbp1重組蛋白
  • 貨號(hào)：
    CSB-EP807018MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ltbp1重組蛋白
  • 貨號(hào)：
    CSB-EP807018MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ltbp1重組蛋白
  • 貨號(hào)：
    CSB-BP807018MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ltbp1重組蛋白
  • 貨號(hào)：
    CSB-MP807018MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ltbp1Latent-transforming growth factor beta-binding protein 1; LTBP-1; Transforming growth factor beta-1-binding protein 1; TGF-beta1-BP-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
  • 基因功能參考文獻(xiàn)：
    1. LTBP1 has a role in female reproduction PMID: 27956181
    2. Data show the complete knockout of both isoforms of LTBP-1 leads to defective cardiovascular development and subsequent perinatal lethality supporting the idea that LTBP-1 is essential in the development of the great arteries and cardiac cushions. PMID: 25805620
    3. Ltbp1 functions in a mechanosensory capacity to establish and maintain mammary gland ductal luminal cell fate, support and detect ductal distension, trigger irreversible involution, and facilitate nipple sphincter function. PMID: 24262428
    4. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. PMID: 23804438
    5. miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. PMID: 23183523
    6. High transforming Growth Factor beta1 expression is associated with myelofibrosis. PMID: 23462118
    7. results suggest a role for VEGFA-driven tumour growth by TGF-beta signalling inhibition via paracrine mechanisms in vivo PMID: 22045186
    8. Study reports that master transcription factors also are responsible for directing the gene targets of TGF-beta signaling and thus determine the cell-type-specific effects of TGF-beta signaling. PMID: 22036565
    9. requirement for TGF-beta signaling into T cells to achieve peripheral CD8 but not CD4 T-cell tolerance PMID: 21422469
    10. Ltbp1L is a major regulator of Tgf-beta activity during valvulogenesis since its absence results in a perturbed Tgf-beta pathway that causes all Ltbp1L(-/-) valvular defects. PMID: 21181942
    11. Shows that Latent Tgfbeta Binding protein 1 (LTBP1), which is a key extracellular modulator of Tgfbeta ligand bioavailability, is coexpressed with Tgfbetas in the early limb bud. PMID: 20565961
    12. IGFBP-3 can bind to LTBP-1 and provide a potential mechanism whereby IGFBP-3 can interact with the TGF-beta system PMID: 12962157
    13. fibronectin has a role in LTBP1 assembly in the ECM and in regulation of TGF beta via LTBP1 interactions PMID: 15677465
    14. integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1 requires fibronectin PMID: 16260650
    15. Cleavage of LTBP1 by BMP1 is involved in TGFbeta1 activation. PMID: 17015622
    16. Data show that the lack of Ltbp1L in the extracellular matrix of the septating cardiac outflow tract and associated vessels results in altered gene expression and function of cardiac neural crest cells and decreased Tgf-beta activity in the OFT. PMID: 17804598
    17. LTBP-1 has essential functions in the control of TGF-beta activation PMID: 17950478
    18. AhR regulates Ltbp-1 transcription by a mechanism involving recruitment of co-activators such as CREB1 and co-repressors such as HDAC2 to the Ltbp-1 promoter. PMID: 18508077
    19. Blocking Tgfb-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. PMID: 18516051
    20. When TGF-beta activity would inhibit further maturation and mineralization, LTBP-1 containing large latent TGF-beta1 complexes that accumulate into the ECM and represent targets for osteoclast mediated release and activation of TGF-beta in bone tissue. PMID: 18672106
    21. Data suggest that association of latent TGF-beta binding protein (LTBP) with the latent TGF-beta complex is important for proper TGF-beta1 function. PMID: 19022904
    22. The long form of LTBP1 (LTBP-1L) is essential for proper heart development. PMID: 17804598

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    LTBP family
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 变态另类牲交乱| 天天干天天日| 久久www色情成人免费| 丰满少妇被粗大猛烈进人高清| 中文字幕精品av乱码在线| 无码精品尤物一区二区三区| 精品人妻无码一区二区三区抖音 | 国产成人欧美亚洲日韩电影| 欧美黑人又粗又大xxx| 手机看片久久国产免费| 国产成人久久av免费高潮| 免费视频爱爱太爽了| 国产精品一区在线蜜臀| 日日噜狠狠噜天天噜av| 国产成人亚洲综合无码精品| 日韩无套内射视频6| 亚洲精品第一国产综合国服瑶| 国产欧美va天堂在线观看视频 | 欧美精品黑人粗大破除| 激情航班h版在线观看| 男男啪啪激烈高潮cc漫画免费| 亚洲这里只有久热精品伊人| 国产精品美女久久久久久福利| 久久国产精品久久久久久| 美女张开腿黄网站免费| 国产亚洲中文日本不卡二区| 国产成人精品日本亚洲999| 熟妇人妻系列av无码一区二区| 熟女无套内射线观56| 果冻传媒mv免费播放在线观看| 果冻传媒亚洲区二期| 久久亚洲中文字幕无码| 2022久久国产精品免费热麻豆| 国产成人a在线观看视频| 亚洲午夜福利院在线观看| 久久人人爽天天玩人人妻精品| 成人无遮羞视频在线观看| a毛片免费全部播放| 免费看又黄又无码的网站| 在线视频夫妻内射| 成年女人看片永久免费视频 |