在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Ltbp1 Antibody, FITC conjugated

  • 中文名稱:
    Ltbp1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA807018LC01MO
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Mus musculus (Mouse) Ltbp1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Ltbp1Latent-transforming growth factor beta-binding protein 1 antibody; LTBP-1 antibody; Transforming growth factor beta-1-binding protein 1 antibody; TGF-beta1-BP-1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Latent-transforming growth factor beta-binding protein 1 protein (20-299AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.
  • 基因功能參考文獻(xiàn):
    1. LTBP1 has a role in female reproduction PMID: 27956181
    2. Data show the complete knockout of both isoforms of LTBP-1 leads to defective cardiovascular development and subsequent perinatal lethality supporting the idea that LTBP-1 is essential in the development of the great arteries and cardiac cushions. PMID: 25805620
    3. Ltbp1 functions in a mechanosensory capacity to establish and maintain mammary gland ductal luminal cell fate, support and detect ductal distension, trigger irreversible involution, and facilitate nipple sphincter function. PMID: 24262428
    4. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. PMID: 23804438
    5. miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. PMID: 23183523
    6. High transforming Growth Factor beta1 expression is associated with myelofibrosis. PMID: 23462118
    7. results suggest a role for VEGFA-driven tumour growth by TGF-beta signalling inhibition via paracrine mechanisms in vivo PMID: 22045186
    8. Study reports that master transcription factors also are responsible for directing the gene targets of TGF-beta signaling and thus determine the cell-type-specific effects of TGF-beta signaling. PMID: 22036565
    9. requirement for TGF-beta signaling into T cells to achieve peripheral CD8 but not CD4 T-cell tolerance PMID: 21422469
    10. Ltbp1L is a major regulator of Tgf-beta activity during valvulogenesis since its absence results in a perturbed Tgf-beta pathway that causes all Ltbp1L(-/-) valvular defects. PMID: 21181942
    11. Shows that Latent Tgfbeta Binding protein 1 (LTBP1), which is a key extracellular modulator of Tgfbeta ligand bioavailability, is coexpressed with Tgfbetas in the early limb bud. PMID: 20565961
    12. IGFBP-3 can bind to LTBP-1 and provide a potential mechanism whereby IGFBP-3 can interact with the TGF-beta system PMID: 12962157
    13. fibronectin has a role in LTBP1 assembly in the ECM and in regulation of TGF beta via LTBP1 interactions PMID: 15677465
    14. integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1 requires fibronectin PMID: 16260650
    15. Cleavage of LTBP1 by BMP1 is involved in TGFbeta1 activation. PMID: 17015622
    16. Data show that the lack of Ltbp1L in the extracellular matrix of the septating cardiac outflow tract and associated vessels results in altered gene expression and function of cardiac neural crest cells and decreased Tgf-beta activity in the OFT. PMID: 17804598
    17. LTBP-1 has essential functions in the control of TGF-beta activation PMID: 17950478
    18. AhR regulates Ltbp-1 transcription by a mechanism involving recruitment of co-activators such as CREB1 and co-repressors such as HDAC2 to the Ltbp-1 promoter. PMID: 18508077
    19. Blocking Tgfb-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. PMID: 18516051
    20. When TGF-beta activity would inhibit further maturation and mineralization, LTBP-1 containing large latent TGF-beta1 complexes that accumulate into the ECM and represent targets for osteoclast mediated release and activation of TGF-beta in bone tissue. PMID: 18672106
    21. Data suggest that association of latent TGF-beta binding protein (LTBP) with the latent TGF-beta complex is important for proper TGF-beta1 function. PMID: 19022904
    22. The long form of LTBP1 (LTBP-1L) is essential for proper heart development. PMID: 17804598

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 蛋白家族:
    LTBP family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 亚洲精品久久久久久下一站| 一区二区三区无码高清视频| 久久亚洲一区二区三区四区| 强插女教师av在线| 久久激情综合狠狠爱五月| 伊人久久精品亚洲午夜| 国产精品久久久久9999| 51视频国产精品一区二区| 国产精品一区二区在线蜜芽tv| 久久久久久好爽爽久久| 国产一精品一av一免费| 人妻无码一区二区三区免费| 成熟女人特级毛片www免费| 亚洲综合久久一本久道| 国产男女爽爽爽免费视频| 丁香五月亚洲综合深深爱| 亚洲开心婷婷中文字幕| 久久久久99精品成人片试看| 国产精品永久免费| 国产爆乳无码av在线播放| 成人亚洲a片v一区二区三区动漫 | 播放灌醉水嫩大学生国内精品 | 青草影院内射中出高潮-百度| 国产av麻豆天堂亚洲国产av刚刚碰| 亚洲中文字幕无码久久| 少妇粉嫩小泬喷水视频| 女人和拘做受全程看视频| 国产jk白丝在线观看免费 | 欧美性生交活xxxxxdddd| 精品人妻va出轨中文字幕| 刺激一区仑乱| 麻豆视传媒精品av| 国产精品视频免费一区二区| 日日噜噜噜夜夜爽爽狠狠| 国产精品国产亚洲区艳妇糸列短篇| 亚洲精品无码成人av电影网| 欧美老妇交乱视频在线观看| 日韩 欧美 国产 一区三| 欧美日韩国产专区一区二区| 久久精品国产99国产精品| 天干夜啦天干天干国产免费|