在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Kynurenine 3-monooxygenase (Kmo), partial

Recombinant Mouse Kynurenine 3-monooxygenase (Kmo), partial

  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-YP849663MO1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-EP849663MO1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-EP849663MO1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-BP849663MO1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-MP849663MO1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kmo
  • Uniprot No.：
  • 別名：
    Kmo; Kynurenine 3-monooxygenase; Kynurenine 3-hydroxylase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
  • 基因功能參考文獻：
    1. Study shows that the development of depression-like behavior in the spared nerve injury model requires brain interleukin-1 signaling and activation of neuronal kynurenine 3-monoxygenase, while pain is independent of this pathway. PMID: 28709913
    2. results demonstrate that the elimination of Kmo in mice is associated with multiple gene and functional alterations that appear to duplicate aspects of the psychopathology of several neuropsychiatric disorders. PMID: 28187857
    3. These results suggest that increased KP metabolites reduced chemokine production, resulting in suppressed mortality upon KMO knockdown in EMCV infection. KP metabolites may thus provide an effective strategy for treating acute viral myocarditis. PMID: 27889626
    4. The findings of this study suggested that KMO KO mice show antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions via abnormality of kynurenine metabolism with good validities as Major depressive disorder model. PMID: 27693848
    5. Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes PMID: 27020856
    6. Mice lacking the enzyme kynurenine-3-monoxygenase (KMO) also showed no changes in hippocampal expression of several of these proteins or the 70-kDa and 100-kDa variants of Disrupted in Schizophrenia-1 (DISC1). PMID: 26365611
    7. KMO KO mice have a robust biochemical phenotype that protects against extrapancreatic tissue injury to the lung, kidney and liver in experimental acute pancreatitis-multiple organ dysfunction syndrome. PMID: 26752518
    8. KMO knockout mice have alterations in the levels of several tryptophan metabolites. PMID: 24189070
    9. expression of KMO by Th17 cells serves to limit their continuous exposure to physiological levels of endogenous aryl hydrocarbon receptor ligands in vivo. PMID: 23568529
    10. partial protection against cerebral malaria was observed in C57BL/6 mice treated with Ro 61-8048, an inhibitor of kynurenine-3-hydroxylase. Protection was associated with suppressed levels of picolinic acid within the brain. PMID: 19000912

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Aromatic-ring hydroxylase family, KMO subfamily
  • 組織特異性：
    Expressed by organs containing secondary lymphoid tissue, such as the lung, spleen, mesenteric lymph node, thymus and peripheral lymph nodes.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 性xxxx搡xxxxx搡欧美| 婷婷伊人五月尤物| 香港aa三级久久三级| 女人和拘做爰正片视频| 国产99视频精品专区| 日本一丰满一bbw| 久久九九久精品国产免费直播| 久久婷婷五月综合色一区二区 | 国产99在线 | 中国| 中国女人高潮hd| 熟妇人妻久久中文字幕| 女人裸露免费视频无遮挡网站| 国产一卡二卡三新区2022| 日本中文字幕在线| 国产婷婷一区二区三区| 久久无码高潮喷水抽搐| 国产精品9999久久久久| 草草影院发布页| 久久精品成人无码观看不卡| 国产成+人+综合+亚洲欧美| 玩两个丰满老熟女| 无遮挡国产高潮视频免费观看| 国产人妻大战黑人第1集| 欧美成 人 网 站 免费| 一本大道伊人av久久综合| 内射毛片内射国产夫妻| 久久国产福利一区二区| 免费一区二区无码东京热| 真人作爱免费视频| 国产精品成人免费999| 一区二区三区毛aaaa片特级| 成人免费无码大片a毛片| 好大好湿好硬顶到了好爽视频| 久久激情综合狠狠爱五月| 果冻传媒18禁免费视频| 色丁香婷婷综合久久| 永久免费观看黄网视频| 亚洲一卡2卡3卡4卡5卡乱码观看| 亚欧洲乱码视频一二三区| 久久www免费人成_看片| 亚洲a∨精品一区二区三区|