在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Kynurenine 3-monooxygenase (Kmo), partial

Recombinant Mouse Kynurenine 3-monooxygenase (Kmo), partial

  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-YP849663MO1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-EP849663MO1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-EP849663MO1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-BP849663MO1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Kmo重組蛋白
  • 貨號：
    CSB-MP849663MO1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Kmo
  • Uniprot No.：
  • 別名：
    Kmo; Kynurenine 3-monooxygenase; Kynurenine 3-hydroxylase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
  • 基因功能參考文獻：
    1. Study shows that the development of depression-like behavior in the spared nerve injury model requires brain interleukin-1 signaling and activation of neuronal kynurenine 3-monoxygenase, while pain is independent of this pathway. PMID: 28709913
    2. results demonstrate that the elimination of Kmo in mice is associated with multiple gene and functional alterations that appear to duplicate aspects of the psychopathology of several neuropsychiatric disorders. PMID: 28187857
    3. These results suggest that increased KP metabolites reduced chemokine production, resulting in suppressed mortality upon KMO knockdown in EMCV infection. KP metabolites may thus provide an effective strategy for treating acute viral myocarditis. PMID: 27889626
    4. The findings of this study suggested that KMO KO mice show antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions via abnormality of kynurenine metabolism with good validities as Major depressive disorder model. PMID: 27693848
    5. Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes PMID: 27020856
    6. Mice lacking the enzyme kynurenine-3-monoxygenase (KMO) also showed no changes in hippocampal expression of several of these proteins or the 70-kDa and 100-kDa variants of Disrupted in Schizophrenia-1 (DISC1). PMID: 26365611
    7. KMO KO mice have a robust biochemical phenotype that protects against extrapancreatic tissue injury to the lung, kidney and liver in experimental acute pancreatitis-multiple organ dysfunction syndrome. PMID: 26752518
    8. KMO knockout mice have alterations in the levels of several tryptophan metabolites. PMID: 24189070
    9. expression of KMO by Th17 cells serves to limit their continuous exposure to physiological levels of endogenous aryl hydrocarbon receptor ligands in vivo. PMID: 23568529
    10. partial protection against cerebral malaria was observed in C57BL/6 mice treated with Ro 61-8048, an inhibitor of kynurenine-3-hydroxylase. Protection was associated with suppressed levels of picolinic acid within the brain. PMID: 19000912

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Aromatic-ring hydroxylase family, KMO subfamily
  • 組織特異性：
    Expressed by organs containing secondary lymphoid tissue, such as the lung, spleen, mesenteric lymph node, thymus and peripheral lymph nodes.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 国产日韩欧美久久久精品图片| 黑人巨茎美女高潮视频| 狠狠色综合网站久久久久久久高清| 大桥未久亚洲一区二区| 国产一区丝袜高跟鞋| 377p欧洲日本亚洲大胆| 亚洲第一av网站| 国产精品美女乱子伦高| 人妻换着玩又刺激又爽| 色悠久久久久久久综合网| 国产精品成人国产乱| 黄网站成人片免费视频| 亚洲精品网站在线观看你懂的| 亚洲人成网站999久久久综合| 国产精品无码无卡无需播放器| 国产在线乱码一区二区三区| 国产精品久久久久久人妻| 3d动漫精品啪啪一区二区下载| 在线观看国产成人av天堂| 国产成人亚洲综合无码品善网 | 无码中出人妻中文字幕av| 精品综合久久久久久8888| xx性欧美肥妇精品久久久久久| 最新高清中文字幕免费mv | 日本二区三区欧美亚洲国| 国产精品99久久精品爆乳| 国产亚洲精品久久久久秋霞不卡| 国产成人愉拍免费视频| 狠狠噜天天噜日日噜| 影音先锋男人站| 日本wv一本一道久久香蕉| 国产成人综合色就色综合| 99精品视频在线观看| 麻豆丰满少妇chinese| 中文字幕亚洲码在线观看| 在厨房拨开内裤进入毛片| 无码写真精品永久福利在线| 久久精品亚洲综合专区| 亚洲国产精品无码久久98| av天堂永久资源网亚洲高清| 2021精品亚洲中文字幕|