在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Interferon-activable protein 204 (Ifi204), partial

In Stock
  • 中文名稱:
    小鼠Ifi204重組蛋白
  • 貨號:
    CSB-EP322750MOa0
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Ifi204
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    28.7 kDa
  • 表達區域:
    216-417aa
  • 氨基酸序列
    QNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMLHATVATVSQYFHVKVFNINLKEKFTKKNFIIISNYFESKGILEINETSSVLEAAPDQMIEVPNSIIRNANASPKICDIQKGTSGAVFYGVFTLHKKTVNRKNTIYEIKDGSGSIEVVGSGKWHNINCKEGDKLHLFCFHLKTIDRQPKLVCGEHSFIKISKRGN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity. Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway. Mechanistically, gets acteylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release. Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation.
  • 基因功能參考文獻:
    1. p204 is a critical component of canonical LPS-TLR4 signaling pathway, and these studies also suggest that p204 could be a potential target to prevent and treat inflammatory and infectious diseases. PMID: 29472103
    2. Importantly, knocking down p204, which is reported as the mouse orthologous of human IFI16, inhibited epidermal hyperplasia in mice with imiquimod-induced psoriasiform dermatitis. These findings indicate that IFI16 plays a critical role in the pathogenesis of psoriasis and may be a potential therapeutic target PMID: 27137868
    3. Ifi204 is required for EPC differentiation. PMID: 27514835
    4. study identifies the AIM2 inflammasome and cGAS/IFI16-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector. PMID: 28947539
    5. p204 initiated innate antiviral responses in adipose cells, thereby modulating adipocyte function. PMID: 25287442
    6. cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. PMID: 25710914
    7. The present study demonstrated that mouse Leydig cells had innate antiviral activities in response to viral DNA challenge through p204 activation. PMID: 24876405
    8. confers resistance to HSV-1 infection in the corneal epithelium PMID: 22236996
    9. Data indicate that the transient expression of p204 in the early stage is indispensable for adipocyte differentiation. Disruption of p204 expression patterns at this stage leads to irreversible damage in fat formation. PMID: 20444940
    10. IFI16 exerts in vivo anti-tumoral activity by promoting apoptosis of tumor cells. PMID: 19553003
    11. acquires malignant transformation capability upon mutation at the Rb-binding sites PMID: 11943193
    12. This gene product interacts with the Tpr protein, a component of the nuclear pore complex. PMID: 12513910
    13. p204 synergizes with pRb in the stimulation of Cbfa1-dependent gene activation and osteoblast differentiation PMID: 17439944
    14. Ifi204 is a regulator of monocyte/macrophage differentiation and make possible a connection with other myeloid regulators [review] PMID: 17981596
    15. p204, a murine member of the p200 family regulates cell proliferation, cell and tissue differentiation (e.g. of skeletal muscle myotubes, beating cardiac myocytes, osteoblasts, chondrocytes and macrophages) and signaling by Ras proteins[review] PMID: 19027346

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族:
    HIN-200 family
  • 組織特異性:
    Present in osteoblasts (at protein level).
  • 數據庫鏈接:

    KEGG: mmu:15951

    UniGene: Mm.261270



主站蜘蛛池模板: 豆国产96在线 | 亚洲| 日产精品卡1卡2卡三卡在线| 国产成人年无码av片在线观看| 欧美亚洲日本高清不卡| 成人无码免费一区二区三区| 免费看美女被靠到爽的视频| 天天爱天天做天天爽夜夜揉| 久久99亚洲含羞草影院| 久久人妻国产精品31| 国产乱辈通伦影片在线播放亚洲| 国产午夜福利短视频| 国产99久一区二区三区a片| 99在线 | 亚洲| 无码少妇一区二区三区视频| 国产精品久久久久无码av| 亚洲妓女综合网99| 亚洲乱码一区二三四区ava| 2020国产亚洲美女精品久久久| 边喂奶边中出的人妻| .精品久久久麻豆国产精品 | 一本色道久久综合狠狠躁| 成年网站未满十八禁视频天堂| 免费看小12萝裸体视频国产| 97婷婷狠狠成为人免费视频| 无码国产色欲xxxxx视频| 老熟妇仑乱视频一区二区| 精品国产成人一区二区三区| 日本工口里番无遮█彩色| 中文字幕人妻无码一夲道| 精品久久久无码中文字幕边打电话| 国产成人手机高清在线观看网站| 亚洲一区二区三区自拍天堂| 欧美深度肠交惨叫| 又污又爽又黄的网站| 成人精品动漫一区二区| 人妻无码中文字幕永久在线| 自慰无码一区二区三区| 久久99国产精一区二区三区| 又爽又黄又无遮挡网站| 欧洲熟妇色xxxx欧美老妇软件| 精品国产sm最大网站|