在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Interferon-activable protein 204 (Ifi204), partial

In Stock
  • 中文名稱:
    小鼠Ifi204重組蛋白
  • 貨號:
    CSB-YP322750MO
  • 規格:
    ¥2616
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    Ifi204
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    Yeast
  • 分子量:
    24.2 kDa
  • 表達區域:
    216-417aa
  • 氨基酸序列
    QNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMLHATVATVSQYFHVKVFNINLKEKFTKKNFIIISNYFESKGILEINETSSVLEAAPDQMIEVPNSIIRNANASPKICDIQKGTSGAVFYGVFTLHKKTVNRKNTIYEIKDGSGSIEVVGSGKWHNINCKEGDKLHLFCFHLKTIDRQPKLVCGEHSFIKISKRGN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity. Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway. Mechanistically, gets acteylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release. Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation.
  • 基因功能參考文獻:
    1. p204 is a critical component of canonical LPS-TLR4 signaling pathway, and these studies also suggest that p204 could be a potential target to prevent and treat inflammatory and infectious diseases. PMID: 29472103
    2. Importantly, knocking down p204, which is reported as the mouse orthologous of human IFI16, inhibited epidermal hyperplasia in mice with imiquimod-induced psoriasiform dermatitis. These findings indicate that IFI16 plays a critical role in the pathogenesis of psoriasis and may be a potential therapeutic target PMID: 27137868
    3. Ifi204 is required for EPC differentiation. PMID: 27514835
    4. study identifies the AIM2 inflammasome and cGAS/IFI16-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector. PMID: 28947539
    5. p204 initiated innate antiviral responses in adipose cells, thereby modulating adipocyte function. PMID: 25287442
    6. cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. PMID: 25710914
    7. The present study demonstrated that mouse Leydig cells had innate antiviral activities in response to viral DNA challenge through p204 activation. PMID: 24876405
    8. confers resistance to HSV-1 infection in the corneal epithelium PMID: 22236996
    9. Data indicate that the transient expression of p204 in the early stage is indispensable for adipocyte differentiation. Disruption of p204 expression patterns at this stage leads to irreversible damage in fat formation. PMID: 20444940
    10. IFI16 exerts in vivo anti-tumoral activity by promoting apoptosis of tumor cells. PMID: 19553003
    11. acquires malignant transformation capability upon mutation at the Rb-binding sites PMID: 11943193
    12. This gene product interacts with the Tpr protein, a component of the nuclear pore complex. PMID: 12513910
    13. p204 synergizes with pRb in the stimulation of Cbfa1-dependent gene activation and osteoblast differentiation PMID: 17439944
    14. Ifi204 is a regulator of monocyte/macrophage differentiation and make possible a connection with other myeloid regulators [review] PMID: 17981596
    15. p204, a murine member of the p200 family regulates cell proliferation, cell and tissue differentiation (e.g. of skeletal muscle myotubes, beating cardiac myocytes, osteoblasts, chondrocytes and macrophages) and signaling by Ras proteins[review] PMID: 19027346

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族:
    HIN-200 family
  • 組織特異性:
    Present in osteoblasts (at protein level).
  • 數據庫鏈接:

    KEGG: mmu:15951

    UniGene: Mm.261270



主站蜘蛛池模板: 精品国产乱码久久久软件下载| 成人做爰视频www网站小优视频| 又色又爽又高潮免费观看| 动漫成人无码精品一区二区三区| 日本丰满人妻xxxxxhd| 性色做爰片在线观看ww| 免费无码黄动漫在线观看| 国产亚洲一卡2卡3卡4卡网站| 亚洲无线码免费| 国产成人精品无码播放| 无码任你躁久久久久久久| а√天堂www在线а√天堂资源| 黑人巨大av在线播放无码| 公么大龟弄得我好舒服秀婷视频| 久久久久久久极品内射| 少妇饥渴偷公乱av在线观看涩爱| 久久精品人人做人人爽97| 巨人精品福利官方导航| aaa少妇高潮大片免费看| 久久精品国产欧美日韩99热| 亚洲精品无码鲁网午夜| 国产精品后入内射日本在线观看| 日韩av无码久久一区二区| 中文成人无码精品久久久动漫| 在线观看午夜亚洲一区| 好吊视频一区二区三区| 亚洲综合小说专区图片| 欧美日韩精品一区二区性色a+v| 精品国产乱码久久久久久婷婷| 国产嫖妓风韵犹存对白| 影音先锋中文无码一区| 久久精品亚洲中文字幕无码网站| 亚洲一区二区三区高清av| 亚洲乱码无人区卡1卡2卡3| 亚洲欧美午夜理论电影在线观看| 黑人巨大精品欧美一区二区| 亚洲国产成人综合一区二区三区 | 少妇被躁爽到高潮无码人狍大战| 50岁退休熟女露脸高潮| 成年网站未满十八禁视频天堂| 亚洲精品中文字幕|