在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Interferon-activable protein 204 (Ifi204), partial

Recombinant Mouse Interferon-activable protein 204 (Ifi204), partial

  • 中文名稱：
    小鼠Ifi204重組蛋白
  • 貨號：
    CSB-YP322750MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ifi204重組蛋白
  • 貨號：
    CSB-EP322750MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ifi204重組蛋白
  • 貨號：
    CSB-BP322750MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ifi204重組蛋白
  • 貨號：
    CSB-MP322750MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ifi204
  • Uniprot No.：
  • 別名：
    Ifi204Interferon-activable protein 204; Ifi-204; Interferon-inducible protein p204
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 表達區域：
    216-417aa
  • 氨基酸序列
    QNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMLHATVATVSQYFHVKVFNINLKEKFTKKNFIIISNYFESKGILEINETSSVLEAAPDQMIEVPNSIIRNANASPKICDIQKGTSGAVFYGVFTLHKKTVNRKNTIYEIKDGSGSIEVVGSGKWHNINCKEGDKLHLFCFHLKTIDRQPKLVCGEHSFIKISKRGN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity. Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway. Mechanistically, gets acteylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release. Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation.
  • 基因功能參考文獻：
    1. p204 is a critical component of canonical LPS-TLR4 signaling pathway, and these studies also suggest that p204 could be a potential target to prevent and treat inflammatory and infectious diseases. PMID: 29472103
    2. Importantly, knocking down p204, which is reported as the mouse orthologous of human IFI16, inhibited epidermal hyperplasia in mice with imiquimod-induced psoriasiform dermatitis. These findings indicate that IFI16 plays a critical role in the pathogenesis of psoriasis and may be a potential therapeutic target PMID: 27137868
    3. Ifi204 is required for EPC differentiation. PMID: 27514835
    4. study identifies the AIM2 inflammasome and cGAS/IFI16-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector. PMID: 28947539
    5. p204 initiated innate antiviral responses in adipose cells, thereby modulating adipocyte function. PMID: 25287442
    6. cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. PMID: 25710914
    7. The present study demonstrated that mouse Leydig cells had innate antiviral activities in response to viral DNA challenge through p204 activation. PMID: 24876405
    8. confers resistance to HSV-1 infection in the corneal epithelium PMID: 22236996
    9. Data indicate that the transient expression of p204 in the early stage is indispensable for adipocyte differentiation. Disruption of p204 expression patterns at this stage leads to irreversible damage in fat formation. PMID: 20444940
    10. IFI16 exerts in vivo anti-tumoral activity by promoting apoptosis of tumor cells. PMID: 19553003
    11. acquires malignant transformation capability upon mutation at the Rb-binding sites PMID: 11943193
    12. This gene product interacts with the Tpr protein, a component of the nuclear pore complex. PMID: 12513910
    13. p204 synergizes with pRb in the stimulation of Cbfa1-dependent gene activation and osteoblast differentiation PMID: 17439944
    14. Ifi204 is a regulator of monocyte/macrophage differentiation and make possible a connection with other myeloid regulators [review] PMID: 17981596
    15. p204, a murine member of the p200 family regulates cell proliferation, cell and tissue differentiation (e.g. of skeletal muscle myotubes, beating cardiac myocytes, osteoblasts, chondrocytes and macrophages) and signaling by Ras proteins[review] PMID: 19027346

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    HIN-200 family
  • 組織特異性：
    Present in osteoblasts (at protein level).
  • 數據庫鏈接：

    KEGG: mmu:15951

    UniGene: Mm.261270



主站蜘蛛池模板： 久爱www成人网免费视频| 国产成人无码精品久久涩吧| 中文无码一区二区视频在线播放量 | 国产揉捏爆乳巨胸挤奶视频| 午夜性色福利在线视频福利| 欧美乱码卡一卡二卡四卡免费| 久久婷婷成人综合色综合| 99国产精品久久99久久久| 国产精品久久久久影院嫩草| 国产毛片精品av一区二区| 无码国产玉足脚交极品网站| 亚洲成aⅴ人片在线观| 亚洲精品无amm毛片| 亚洲欧美另类久久久精品| 日产亚洲一区二区三区| 中国农村妇女真实bbwbbwbbw| 日本无遮挡吸乳呻吟视频| 国产裸体美女永久免费无遮挡| 精品乱码一区二区三四区视频| 国产97色在线 | 国产| 肉感饱满中年熟妇日本| 日产精品中文一区二区三区| 久久中文字幕无码专区 | 在线播放无码后入内射少妇| 果冻传媒2021精品一区| 欧洲精品一卡2卡三卡4卡影视| 精品久久久久久久国产潘金莲| 国产在线视频www色| 中文字幕日韩精品一区二区三区| 日产精品高潮呻吟av久久| 久久久久国色av∨免费看| 国产丝袜美女| 国产午夜精品无码| 人人妻人人澡人人爽国产| 成人网站精品久久久久| 亚洲理论电影在线观看| 免费无码又爽又刺激网站| 无尺码精品产品视频| 亚洲人成77在线播放网站| 欧美人伦禁忌dvd放荡欲情| 成年美女黄网站色大片免费看 |