在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Glypican-3 (Gpc3), partial

Recombinant Mouse Glypican-3 (Gpc3), partial

  • 中文名稱：
    小鼠Gpc3重組蛋白
  • 貨號：
    CSB-YP804039MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Gpc3重組蛋白
  • 貨號：
    CSB-EP804039MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Gpc3重組蛋白
  • 貨號：
    CSB-EP804039MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Gpc3重組蛋白
  • 貨號：
    CSB-BP804039MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Gpc3重組蛋白
  • 貨號：
    CSB-MP804039MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Gpc3; Glypican-3 [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 表達區域：
    -
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cell surface proteoglycan that bears heparan sulfate. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway. Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression. Inhibits the dipeptidyl peptidase activity of DPP4. Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4. Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis. Required for coronary vascular development. Plays a role in regulating cell movements during gastrulation.
  • 基因功能參考文獻：
    1. Coupling of pGPC3 to liposomes was essential for effective priming of GPC3-specific CTLs. PMID: 26616051
    2. The expression of GPC-3 was altered by DEN treatment. PMID: 24377529
    3. Finding represents a rare four layer genomic overlap consisting of growth associated quantitative trait locus (QTL), body mass associated Gpc3 gene, highly conserved miRNA gene and mature miRNA seed SNP identified in the lean mouse. PMID: 21152117
    4. Hepatocyte overexpression of GPC3 suppresses hepatocyte proliferation and liver regeneration and alters gene expression profiles. PMID: 20812357
    5. glypican-3 is involved in the recruitment of M2-polarized tumor-associated macrophages in hepatocellular carcinoma PMID: 19838081
    6. GPC3 inhibits the PI3K/Akt anti-apoptotic pathway while it stimulates the p38MAPK stress-activated one in murine mammary adenocarcinoma LM3 cells PMID: 19288189
    7. Gpc3 function in development of Simpson-Golabi-Behmel syndrome is IGF-independent PMID: 11846487
    8. GPC3 knockout mice exhibit alterations in the Wnt signaling pathway, which is also associated with the regulation of cell proliferation PMID: 15537637
    9. Polymorphisms in the 3' untranslated region of Gpc3 are strong candidates for the causal sequence variation and loss-of-function mutations can cause overgrowth and developmental abnormalities. PMID: 15799711
    10. Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. PMID: 15936336
    11. Zhx2 acts as a repressor of Gpc3 in the adult liver. Gpc3 is activated in the regenerating liver in an Afr2-dependent manner. PMID: 17668883
    12. A novel glycosyl phosphatidyl inositol (GPI)-linked proteoglycan, Glypican3 (GPC3, binding to GLUT4 was identified. PMID: 18343214
    13. Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation. PMID: 18404367
    14. GPC3 acts as a negative regulator of Hedgehog signaling during mammalian development. PMID: 18477453
    15. The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis. PMID: 19479939
    16. The Gpc3-null mice show increased levels of Ihh protein and signalling, but similar levels of Ihh messenger RNA. PMID: 19590577
    17. Data show that glypican-3-deficient mice display a high incidence of congenital cardiac malformations like ventricular septal defects, common atrioventricular canal and double outlet right ventricle. PMID: 19733558

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
  • 蛋白家族：
    Glypican family
  • 組織特異性：
    In the developing limb, absent from the apical epidermal ridge at 11 dpc but highly expressed in the underlying mesenchyme. Expression in the mesenchyme at this stage is asymmetric with highest levels in the regions of the distal mesenchyme within the pro
  • 數據庫鏈接：


主站蜘蛛池模板： 无尺码精品产品网站| 婷婷五月开心亚洲综合在线| 国语高潮无遮挡无码免费看| 日本又黄又爽gif动态图| 国产精品99久久久久久人| 性按摩xxxx在线观看| av一区二区三区人妻少妇| 女上男下啪啪激烈高潮无遮盖 | 中文字幕人乱码中文| 夜夜影院未满十八勿进| 免费国产va在线观看| 亚洲国产精品久久久久爰| 国内嫩模私拍精品视频| 亚洲精品一区二区三区在线| 亚洲看片lutube在线观看| 久久99亚洲精品久久久久| 久久精品国产一区二区电影| 国产肉体ⅹxxx137大胆| 久久人妻无码aⅴ毛片a片app| 饥渴少妇高潮视频大全| 性按摩玩人妻hd中文字幕| 无码人妻精品中文字幕| 一本大道在线观看无码一区| 性色香蕉av久久久天天网| 日韩精品久久无码中文字幕| 成人国产mv免费视频| 免费无码成人av片在线| 国产人妻777人伦精品hd| 亚洲成熟女人毛毛耸耸多| 国产成人久久精品流白浆| 午夜视频久久久久一区| 久久久久久一区国产精品| 性欧美大战久久久久久久| 色噜噜狠狠色综合成人网| 偷窥国产亚洲免费视频| 国产精品亚洲专区无码破解版| 乌克兰少妇性做爰| 精品香蕉久久久午夜福利| 国产精品自在拍首页视频8| 69堂人成无码免费视频果冻传媒| 男人和女人高潮免费网站|