在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Folate receptor alpha (Folr1)

Recombinant Mouse Folate receptor alpha (Folr1)

  • 中文名稱：
    小鼠Folr1重組蛋白
  • 貨號：
    CSB-YP008784MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Folr1重組蛋白
  • 貨號：
    CSB-EP008784MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Folr1重組蛋白
  • 貨號：
    CSB-EP008784MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Folr1重組蛋白
  • 貨號：
    CSB-BP008784MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Folr1重組蛋白
  • 貨號：
    CSB-MP008784MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Folr1; Fbp1; Folbp1Folate receptor alpha; FR-alpha; Folate receptor 1; Folate-binding protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    25-232
  • 氨基酸序列
    TRARTE LLNVCMDAKH HKEKPGPEDN LHDQCSPWKT NSCCSTNTSQ EAHKDISYLY RFNWNHCGTM TSECKRHFIQ DTCLYECSPN LGPWIQQVDQ SWRKERILDV PLCKEDCQQW WEDCQSSFTC KSNWHKGWNW SSGHNECPVG ASCHPFTFYF PTSAALCEEI WSHSYKLSNY SRGSGRCIQM WFDPAQGNPN EEVARFYAEA MS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.
  • 基因功能參考文獻：
    1. Several experimental studies in mice and human epidemiological and genetics studies have suggested that FOLR1 abnormalities are involved in a portion of human neural tube defects (NTD), although the solo defect of FOLR1 did not cause NTD. (Review) PMID: 28244241
    2. Midbrain dopamine neural progenitors and nascent dopamine neurons specifically express Folr1. PMID: 27580818
    3. The above showed that human FRalpha based DNA vaccination with CpG oligodeoxynucleotides as an adjuvant was effective in growth inhibition of a FRalpha expressing tumor in mice and deserves further evaluation as a possible immunotherapy PMID: 28498413
    4. Folate receptor alpha upregulates Oct4, Sox2 and Klf4 and downregulates miR-138 and miR-let-7 in cranial neural crest cells. PMID: 27300003
    5. not detected in oocytes PMID: 27122634
    6. Folate receptor expression on murine and human adipose tissue macrophages PMID: 26149693
    7. Quantitative RT-PCR showed that Slc19a1 mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed expression only in preimplantation embryos, increasing from the 2-cell stage onward. PMID: 23904512
    8. under conditions of reduced folate (Folr-/-) signalling, pathways crucial for proper development of the neural tube are significantly altered. PMID: 21649587
    9. Nesting of T helper cell epitopes results in recruitment of latent pools of naive high-affinity/avidity folate receptor (FR)alpha-specific T cells, which have the ability to home to tumors expressing FRalpha and to reduce tumor burden. PMID: 21613617
    10. Fbp1 has a role in anterior neural tube closure PMID: 12508232
    11. Neural and orofacial defects are associated with Folbp1 knockout mice PMID: 12854656
    12. Expression of genes in the anterior neural tube of gestational day 9 Folbp1-/- embryos PMID: 15176467
    13. Has a prominent role in mediating susceptibility to heart defects. PMID: 15259034
    14. folbp1 is essential for normal renal tubular folate reabsorption, preventing excessive urinary folate loss PMID: 15703271
    15. Folbp1 regulates apoptosis and cell proliferation that underlies the aberrant neural tube and craniofacial defects PMID: 15800851
    16. Abnormal heart looping was observed during early development of Folr1(-/-) embryos partially rescued by maternal folinic acid supplementation. PMID: 17286298
    17. folate receptor type beta is induced in a bone marrow engraftment model of acute myelogenous leukemia PMID: 17554378
    18. Folr1 gene ablation and abnormal folate homeostasis altered gene expression in developing heart and conotruncal tissues PMID: 18028541
    19. These findings findings suggest that FRalpha plays a role in pituitary tumor formation, and this effect may in part be due to its regulation of the NOTCH3 pathway. PMID: 18804697
    20. FOLR1 is a target for regulation by HNF4-alpha in visceral endoderm. PMID: 19180647
    21. Folbp1 may be an important candidate mediator of folic acid deficiency-induced congenital cardiac anomalies which are induced by the dysfunction of proliferation and apoptosis of the myocardial cell PMID: 19212649

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane.
  • 蛋白家族：
    Folate receptor family
  • 組織特異性：
    Detected in kidney proximal tubules (at protein level).
  • 數據庫鏈接：


主站蜘蛛池模板： 精品午夜国产福利观看| 日本乱妇乱子视频网站-百度| 天堂网www中文在线| 精品国产一区二区三区久久狼| 亚洲精品无码久久久久秋霞| 天天做天天爱夜夜爽毛片毛片| 免费精品国产人妻国语| 久久精品国产精品亚洲下载| 偷窥村妇洗澡毛毛多| 免费国产在线精品一区二区三区 | 成人无码影片精品久久久| 亚洲人成电影在线播放| 色欲天天婬色婬香综合网完整版| 性欧美俄罗斯乱妇| 真人作爱90分钟免费看视频| 亚洲a成人片在线观看| 国产激情久久久久影院小草| 成人av片在线观看免费| 久久综合亚洲欧美成人| 久久99精品久久久久子伦| 无码人妻啪啪一区二区| 国产在线观看超清无码视频一区二区| 99爱在线精品视频免费观看| 精品人妻少妇一区二区三区| 亚洲欧美精品伊人久久| 国产亚洲福利在线视频| 让少妇爽到高潮视频| 日韩欧美在线综合网| 成人欧美一区二区三区在线| 久久久国产精品va麻豆| 色无码av在线播放| 麻豆精品导航| 亚洲中文字幕无码久久2020 | 黄桃av无码免费一区二区三区 | 加勒比色综合久久久久久久久 | 丰满日韩放荡少妇无码视频| 亚洲伊人久久成人综合网 | 国产熟妇高潮叫床视频播放| 人人妻人人澡人人爽人人精品97 | 又色又爽又黄还免费毛片96下载| 国产精品永久在线观看|