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  4. Recombinant Mouse Ficolin-2 (Fcn2)

Recombinant Mouse Ficolin-2 (Fcn2)

  • 中文名稱：
    小鼠Fcn2重組蛋白
  • 貨號：
    CSB-YP008551MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Fcn2重組蛋白
  • 貨號：
    CSB-EP008551MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Fcn2重組蛋白
  • 貨號：
    CSB-EP008551MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Fcn2重組蛋白
  • 貨號：
    CSB-BP008551MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Fcn2重組蛋白
  • 貨號：
    CSB-MP008551MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Fcn2
  • Uniprot No.：
  • 別名：
    Fcn2; FcnbFicolin-2; Collagen/fibrinogen domain-containing protein 2; Ficolin-B; Ficolin-beta; L-ficolin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    18-314
  • 氨基酸序列
    AGT CPELKVLDLE GYKQLTILQG CPGLPGAAGP KGEAGAKGDR GESGLPGIPG KEGPTGPKGN QGEKGIRGEK GDSGPSQSCA TGPRTCKELL TQGHFLTGWY TIYLPDCRPL TVLCDMDTDG GGWTVFQRRL DGSVDFFRDW TSYKRGFGSQ LGEFWLGNDN IHALTTQGTS ELRVDLSDFE GKHDFAKYSS FQIQGEAEKY KLILGNFLGG GAGDSLTPHN NRLFSTKDQD NDGSTSSCAM GYHGAWWYSQ CHTSNLNGLY LRGPHKSYAN GVNWKSWRGY NYSCKVSEMK VRLI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin.
  • 基因功能參考文獻：
    1. this study shows that FCN B plays an important role in the development of collagen Ab-induced arthritis PMID: 28739878
    2. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PMID: 24040095
    3. Data show that ficolin-B is stored in and set free from immature granulocytic myeloid cells indicating a role in the early infection-induced cellular response of these inflammatory cells. PMID: 23911405
    4. These results identify mouse ficolin-B as a functional member of the ficolin family activating complement via the lectin pathway. PMID: 22459270
    5. Results show that ficolin B in mouse bone marrow is an oligomeric protein. Ficolin B contained very low, but detectable, amounts of MASP-2 and sMAP and showed detectable C4-deposition activity on immobilized N-acetylglucosamine. PMID: 22523468
    6. Ficolin B exhibited a distinct ontogeny pattern that switched from embryonic liver to postnatal bone marrow and spleen. The cells that express ficolin B mRNA were identified as belonging to the myeloid cell lineage. PMID: 15950722
    7. Ficolin B showed multimeric structures and revealed binding to both N-acetylglucosamine and N-acetylgalactosamine. Ficolin B specifically recognized sialic acid residues. Ficolin B plays a distinct role through its unique carbohydrate-binding specificity. PMID: 16328467

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Ficolin lectin family
  • 數據庫鏈接：


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