在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Eukaryotic initiation factor 4A-III (Eif4a3)

Recombinant Mouse Eukaryotic initiation factor 4A-III (Eif4a3)

  • 中文名稱：
    小鼠Eif4a3重組蛋白
  • 貨號：
    CSB-YP835561MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Eif4a3重組蛋白
  • 貨號：
    CSB-EP835561MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Eif4a3重組蛋白
  • 貨號：
    CSB-EP835561MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Eif4a3重組蛋白
  • 貨號：
    CSB-BP835561MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Eif4a3重組蛋白
  • 貨號：
    CSB-MP835561MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Eif4a3
  • Uniprot No.：
  • 別名：
    Eif4a3; Ddx48; Eukaryotic initiation factor 4A-III; eIF-4A-III; eIF4A-III; EC 3.6.4.13; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; Eukaryotic translation initiation factor 4A isoform 3) [Cleaved into: Eukaryotic initiation factor 4A-III; N-terminally processed]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-411
  • 氨基酸序列
    MAANATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSVSVLQCL DIQVRETQAL ILAPTRELAV QIQKGLLALG DYMNVQCHAC IGGTNVGEDI RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA IKMLVLDEAD EMLNKGFKEQ IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL VKRDELTLEG IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII NYDLPNNREL YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI DEMPMNVADL I
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development.
  • 基因功能參考文獻：
    1. we first show that Eif4a3 haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53, significantly rescues microcephaly of all 3 EJC mutant PMID: 27618312
    2. The knockdown of PRPF19 or EIF4A3 decreased splicing of Lhb, or of both beta subunit transcripts, respectively. PMID: 18480465
  • 亞細胞定位：
    Nucleus. Nucleus speckle. Cytoplasm.
  • 蛋白家族：
    DEAD box helicase family, eIF4A subfamily
  • 數據庫鏈接：


主站蜘蛛池模板： 国内精品久久久久影院日本| 亚洲欧美成人久久一区| 在线播放免费播放av片| 国产精品激情| 亚洲人成色77777在线观看| 动漫精品啪啪一区二区三区| 欧美乱码精品一区二区三区| 欧美成人精品一区二区综合a片| 色综合久久婷婷五月| 伴郎粗大的内捧猛烈进出视频观看 | 国产精品成人av在线观看春天| 老妇肥熟凸凹丰满刺激| 麻豆熟妇人妻xxxxxx| 国产亚洲精品视觉盛宴| 伊人成色综合网| 久久高清内射无套| 精品国产国语对白久久免费 | 美女裸体色黄污视频网站| 亚洲成av人片不卡无码久久 | 在线观看国产一区二区三区| 亚洲中文字幕无码专区| 天堂最新版资源网| 羞羞影院午夜男女爽爽| 好了av四色综合无码| 国产精品乱码在线观看| 草裙社区精品视频三区免费看| 精品无码一区二区三区的天堂| 偷拍区清纯另类丝袜美腿| 冲田杏梨av一区二区三区 | 午夜免费啪视频| 无码专区 人妻系列 在线| 超caopor在线公开视频| 亚洲国产a∨无码中文777| 国产天美传媒性色av| 无码尹人久久相蕉无码| 私人家庭影院5777| 中字幕视频在线永久在线观看免费| 人妻熟女一二三区夜夜爱| 日韩精品一区二区av在线| 亚洲精品成av人片天堂无码| 国产情侣一区二区三区|