在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse E3 ubiquitin-protein ligase NRDP1 (Rnf41)

  • 中文名稱:
    小鼠Rnf41重組蛋白
  • 貨號:
    CSB-YP805890MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Rnf41重組蛋白
  • 貨號:
    CSB-EP805890MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Rnf41重組蛋白
  • 貨號:
    CSB-EP805890MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Rnf41重組蛋白
  • 貨號:
    CSB-BP805890MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Rnf41重組蛋白
  • 貨號:
    CSB-MP805890MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Rnf41; Flrf; Nrdp1; E3 ubiquitin-protein ligase NRDP1; EC 2.3.2.27; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-317
  • 氨基酸序列
    MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC GLEMPKDELP NHNCIKHLRS VVQQQQSRIA ELEKTSAEHK HQLAEQKRDI QLLKAYMRAI RSVNPNLQNL EETIEYNEIL EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLVESGCPA SIVNELIENA HERSWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGDDM VQEPGLVMIF AHGVEEI
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.
  • 基因功能參考文獻:
    1. The novel Pdx1-Clec16a-Nrdp1 pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes. PMID: 26085571
    2. demonstrate that Nrdp1-mediated ubiquitination and activation of C/EBPbeta contributes to a ubiquitin-dependent nonproteolytic pathway that up-regulates Arg1 expression and promotes M2 macrophage polarization PMID: 22707723
    3. Nrdp1 may be a key mediator in the development of cardiac dysfunction after DOX treatment and associated with inhibition of Akt, ERK1/2 and STAT3. PMID: 21738612
    4. these results provide evidence for an important role for Nrdp1 in regulating ischemia/reperfusioninduced cardiac injury PMID: 21312039
    5. Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. PMID: 20628057
    6. Rnf41 is nominated as a candidate gene for anxiety-like behaviors, depression, and vulnerability to seizures. PMID: 18986647

    顯示更多

    收起更多

  • 數據庫鏈接:


主站蜘蛛池模板: 800av凹凸视频在线观看| 蜜桃视频在线观看免费视频网站www| 狠狠躁天天躁中文字幕| 国产一区二区波多野结衣| 亚洲国产综合精品 在线 一区 | 成人午夜高潮免费视频| 荡女精品导航| 亚洲卡1卡2卡新区网站| 成人性生交大片免费看r老牛网站| 国产国语毛片在线看国产| 动漫av纯肉无码av电影网| 亚洲大尺度专区无码浪潮av| 国产欧美精品一区二区色综合 | 狂野欧美性猛交xxxx| 国产亚洲精品久久久久久| 国产黑色丝袜在线观看下| 国产高清视频在线观看69| 久久综合九色综合欧洲98| 国产精品久久久久久亚洲色| 伊伊人成亚洲综合人网7777| 好爽毛片一区二区三区四| 精品久久一区二区乱码| 裸体女人高潮毛片| 国产精品亚洲аv久久| 亚洲中文字幕无码中文字在线| 免费无码黄动漫在线观看| 亚洲香蕉网久久综合影视| 一本清日本在线视频精品| 成人毛片18女人毛片免费| 黄a无码片内射无码视频| 偷偷做久久久久网站| 亚洲国产精品成人精品无码区 | 亚洲午夜性猛春交xxxx| 精品日本一区二区免费视频| 天干天干啦夜天干天天爽| 人妻夜夜添夜夜无码av| 中文字幕精品一区二区精品| 97人人添人澡人人爽超碰| 日本xxxxx片免费观看喷水| 免费无码鲁丝片一区二区| 少妇人妻精品一区二区|