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RNF41

E3 ubiquitin-protein ligase NRDP1 is a protein in humans that is encoded by RNF41 gene. Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis.

RNF41 Antibodies

RNF41 for Homo sapiens (Human)

RNF41 Proteins

RNF41 Proteins for Xenopus laevis (African clawed frog)

RNF41 Proteins for Pongo abelii (Sumatran orangutan)

RNF41 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

RNF41 Proteins for Mus musculus (Mouse)

RNF41 Proteins for Homo sapiens (Human)



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