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  4. Recombinant Mouse E1A-binding protein p400 (Ep400), partial

Recombinant Mouse E1A-binding protein p400 (Ep400), partial

  • 中文名稱：
    小鼠Ep400重組蛋白
  • 貨號：
    CSB-YP807030MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ep400重組蛋白
  • 貨號：
    CSB-EP807030MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ep400重組蛋白
  • 貨號：
    CSB-EP807030MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ep400重組蛋白
  • 貨號：
    CSB-BP807030MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ep400重組蛋白
  • 貨號：
    CSB-MP807030MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ep400
  • Uniprot No.：
  • 別名：
    Ep400; Kiaa1498E1A-binding protein p400; EC 3.6.4.-; Domino homolog; mDomino; p400 kDa SWI2/SNF2-related protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Regulates transcriptional activity of ZNF42.
  • 基因功能參考文獻(xiàn)：
    1. incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation PMID: 23064015
    2. p400/mDomino plays a key role in cellular proliferation by controlling the expression of cell-cycle-regulatory genes. PMID: 20610385
    3. p400 is a regulator of the ARF-p53 pathway and a component of the cellular machinery that couples proliferation to cell death PMID: 15741165
    4. p400/mDomino plays a critical role in embryonic hematopoiesis by regulating the expression of developmentally essential genes such as those in the Hox gene cluster. PMID: 17535249
    5. senescence induced by VHL inactivation is a tumour-suppressive mechanism mediated by Rb and p400 (and HIF independent) that must be overcome to develop VHL-associated neoplasias PMID: 18297059
    6. These data indicate that Tip60-p400 integrates signals from Nanog and H3K4me3 to regulate gene expression in embryonic stem cells. PMID: 18614019

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    SNF2/RAD54 helicase family, SWR1 subfamily
  • 組織特異性：
    Expressed in brain, thymus, lung, liver, spleen, kidney, colon and bone marrow.
  • 數(shù)據(jù)庫鏈接：


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