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  4. Recombinant Mouse Dickkopf-like protein 1 (Dkkl1)

Recombinant Mouse Dickkopf-like protein 1 (Dkkl1)

  • 中文名稱：
    小鼠Dkkl1重組蛋白
  • 貨號：
    CSB-YP870787MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Dkkl1重組蛋白
  • 貨號：
    CSB-EP870787MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Dkkl1重組蛋白
  • 貨號：
    CSB-EP870787MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Dkkl1重組蛋白
  • 貨號：
    CSB-BP870787MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Dkkl1重組蛋白
  • 貨號：
    CSB-MP870787MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Dkkl1
  • Uniprot No.：
  • 別名：
    Dkkl1; Sgy1Dickkopf-like protein 1; Protein soggy-1; SGY-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    21-230
  • 氨基酸序列
    LPIHDVDSQQ NTSGFLGLQR LLQSFSRLFL KNDLLRDLDN FFSSPMDFRD LPRNFHQEEN QEHRMGNHTL SSHLQIDKVT DNQTGEVLIS EKVEASIEPE RNPEGDWKVP KVEAKEPPVP VQKVTDSLHP EPRQVAFWIM KMPRRRTQPD VQDGGRWLIE KRHRMQAIRD GLRGGAREDS LEDGVHIPQH AKLPVRKTHF LYILRPSQQL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
  • 基因功能參考文獻：
    1. Dkkl1 may not be essential for normal brain organization, but could exert import functions during pathological conditions such as tumorigenesis and cancer progression. PMID: 23295900
    2. DKKL1/Dkkl1 may play an important role in testicular development and spermatogenesis and may be an important factor in male infertility. PMID: 22817830
    3. DKKL1 is a mammalian-specific acrosomal protein that is not essential either for development or fertility. PMID: 19596310
    4. DKKL1 is a mammalian-specific, acrosomal protein that strongly affects in vitro fertilization, although the effect is attenuated in vivo. PMID: 19596312
    5. Dkkl1 is a negative regulator of adult testis homeostasis that specifically controls the number of postpubertal spermatocytes. PMID: 18818293
    6. SLY1 interacts with acrosomal protein DKKL1, histone acetyltransferase KAT5 & microtubule-associated protein APPBP2; data suggest SLY1 may be involved in spermiogenesis processes, including control of gene expression & acrosome development or function PMID: 19176879

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  • 亞細胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.
  • 組織特異性：
    Testis-specific. Abundant in the seminiferous tubules where it is associated with developing spermatocytes. Expressed only in testis (at protein level). Not detectable on postnatal days 4 and 9 but after day 18 it gradually increased as the development of
  • 數據庫鏈接：


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