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  4. Recombinant Mouse Contactin-associated protein-like 2 (Cntnap2), partial

Recombinant Mouse Contactin-associated protein-like 2 (Cntnap2), partial

  • 中文名稱：
    Recombinant Mouse Contactin-associated protein-like 2(Cntnap2) ,partial
  • 貨號：
    CSB-YP863406MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Contactin-associated protein-like 2(Cntnap2) ,partial
  • 貨號：
    CSB-EP863406MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Contactin-associated protein-like 2(Cntnap2) ,partial
  • 貨號：
    CSB-EP863406MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Contactin-associated protein-like 2(Cntnap2) ,partial
  • 貨號：
    CSB-BP863406MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Contactin-associated protein-like 2(Cntnap2) ,partial
  • 貨號：
    CSB-MP863406MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cntnap2
  • Uniprot No.：
  • 別名：
    Cntnap2; Kiaa0868Contactin-associated protein-like 2; Cell recognition molecule Caspr2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for gap junction formation. Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction (Probable).
  • 基因功能參考文獻：
    1. This study demonstrated an age-dependent effect of Cntnap2 deletion on both tonic and phasic inhibition in layer 2/3 pyramidal cells in the visual cortex. PMID: 28966979
    2. native medial prefrontal cortex parvalbumin neuronal activity differed between CNTNAP2 knockout and wild-type mice. PMID: 28768803
    3. Caspr2/Caspr1 double mutants results in muscle fiber degeneration accompanied by mitochondrial dysfunction. PMID: 28370195
    4. Cntnap2 KO rats exhibited severe motor seizures, hyperactivity, and increased consolidation of wakefulness and REM sleep. By contrast, Cntnap2 KO mice demonstrated absence seizure-like events, hypoactivity, and wake fragmentation. PMID: 28364455
    5. After middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs. In addition, there is suppression of the language-associated transcription factor,contactin-associated protein 2 (Cntnap2). PMID: 26889967
    6. These findings suggest that contactin-associated-like-protein 2 may influence the development of neural systems important to learning and cross-modal integration, and that disruption of this function could be associated with delayed learning in autism spectrum disorder. PMID: 26873041
    7. Olfaction-based behavioral tests revealed that mice lacking Caspr2 exhibit abnormal response to sensory stimuli and lack preference for novel odors. PMID: 26647347
    8. Mice with the Cntnap2 genetic mutation showed a dissociation of auditory-processing abilities PMID: 26501174
    9. Study reports behavioral characterization of mouse models of autism with null mutation in Cntnap2 gene. It shows hyperactivity, mild gait phenotype and reduced vocalizations among others. PMID: 26273832
    10. new dendritic spines in mice lacking CNTNAP2 were formed at normal rates, but failed to stabilize. Notably, rates of spine elimination were unaltered, suggesting a specific role for CNTNAP2 in stabilizing new synaptic circuitry PMID: 25951243
    11. Cntnap2 deletion selectively impairs perisomatic hippocampal inhibition while sparing excitation provide additional support for synaptic dysfunction as a common mechanism underlying autism spectrum disorders PMID: 26511255
    12. The CASPR2/MUPP1 receptor complex co-localized with GPR37 in hippocampal neurons. PMID: 25977097
    13. CNTNAP2 has a role in the correct trafficking of GluA1 AMPA-type glutamate receptors PMID: 25918374
    14. Caspr2 is required for paranodal clustering of Kv1 channels in the absence of Caspr. Absence of both Caspr and Caspr2 results in the widening of the nodes of Ranvier. PMID: 25378149
    15. these observations suggest that Foxp2 may regulate ultrasonic vocalization by associating with CtBP in Purkinje cells PMID: 22133810
    16. Data demonstrate a functional role for CNTNAP2 in brain development PMID: 21962519

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Cell projection, axon. Cell junction, paranodal septate junction.
  • 蛋白家族：
    Neurexin family
  • 組織特異性：
    In sciatic nerve predominantly found at the juxtaparanodal regions (at protein level).
  • 數據庫鏈接：


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