在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Cis-aconitate decarboxylase (Acod1)

In Stock
  • 貨號(hào):
    CSB-EP011825MO
  • 規(guī)格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    Acod1
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    61.3 kDa
  • 表達(dá)區(qū)域:
    1-488aa
  • 氨基酸序列
    MMLKSVTESFAGMIHGLKVNHLTDGIIRRSKRMILDSLGVGFLGTGTEVFHKVTQYSKIYSSNTSSTVWGRPDFRLPPTYAAFVNGVAVHSMDFDDTWHPATHPSGAVLPVLTALSEALPQIPKFSGLDLLLAFNVGIEVQGRLMHFSKEAKDIPKRFHPPSVVGTLGSAAAASKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPLHIGNAAKHGMEATFLAMLGLQGNKQILDLGSGFGAFYANYSPEDLPSLDSHIWLLDQQDVAFKSFPAHLATHWVADAAAAVRKHLVTPERALFPADHIERIVLRIPDVQYVNRPFPDSEHEARHSFQYVACASLLDGSITVPSFHSQQVNRPQVRELLKKVKLEHPPDNPPSFDTLYCEISITLKDGTTFTERSDTFYGHWRKPLSQEDLRNKFRANASKMLCRDTVESLITVVEKLEDLEDCSVLTRLLKGPSVQDEASKLSSMSSFDHTTLPRFTNI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.
  • 基因功能參考文獻(xiàn):
    1. Loss of itaconate production in activated macrophages from Irg1(-/-) mice decreases the accumulation of succinate in response to LPS exposure PMID: 27189937
    2. LPS-stimulated TNF-alpha was significantly decreased, whereas IRG1 and A20 were increased by CORM-2 application and HO-1 induction, which in turn were abrogated by ZnPP. PMID: 25640654
    3. inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxin tolerance. PMID: 23609450
    4. IRG1 links cellular metabolism with immune defense by catalyzing itaconic acid production PMID: 23610393
    5. show that the delayed but highly effective clearance of intrauterine Chlamydia trachomatis infections in Irgm1/m3((-/-)) mice is dependent on an exacerbated CD4(+) T cell response PMID: 21731484
    6. PKC pathway is induced in the uterine epithelium at implantation by the synergistic action of progesterone and estrogen and is responsible for the hormone induction of Irg1 PMID: 12893884
    7. Irg1 is a novel target of progesterone receptor in the pregnant uterus and also revealed that it is a critical regulator of the early events leading to implantation. PMID: 14500577
    8. Thus, our data demonstrate that transcriptional and post-transcriptional mechanisms are responsible for a differential IRG1 gene expression in murine macrophages treated with LPS, MAP, and M. smegmatis. PMID: 16415166
    9. IRG1 is highly upregulated in murine ANA-1 macrophages by several proinflammatory cytokines and Toll-like receptor (TLR) agonists, as well as in spleen and lung of Listeria monocytogenes or Toxoplasma gondii infected mice, respectively PMID: 19014335

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion.
  • 蛋白家族:
    PrpD family
  • 組織特異性:
    Expressed in LPS-tolerized macrophages (at protein level). Expressed in the luminal epithelial cells of pregnant uterus. Expressed in microglia and macrophage cells.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产免费麻传媒精品国产av| 色噜噜狠狠狠综合曰曰曰| 九九视频麻婆豆腐在线观看| 男女做爰无遮挡性视频| 午夜不卡无码中文字幕影院| 一二三四在线视频社区3| 熟女少妇内射日韩亚洲| 中文天堂最新版在线www| 熟女乱牛牛视频在线观看| 久久久精品人妻一区二区三区蜜桃 | 99久久人妻无码精品系列蜜桃| 欧美在线看片a免费观看| av无码电影一区二区三区| av在线播放日韩亚洲欧我不卡| 热99re久久精品| 日韩成人一区二区三区在线观看| 欧美黑人与白人精品a片| 国产午夜福利精品一区| 亚洲bbw性色大片| 国产精品免费看久久久| 男女裸交免费无遮挡全过程| 无码av一区二区大桥久未| 亚洲精品无码久久久久av老牛| 宝宝好涨水快流出来免费视频| 精品国产美女福到在线不卡 | 女人与拘性猛交视频| 亚洲中文字幕在线第二页| 国产360激情盗摄全集| 手机看片久久国产免费| 男人和女人高潮免费网站| а√天堂www在线а√天堂视频| 精品多人p群无码| 免费又黄又硬又爽大片| 无码中文字幕日韩专区| 亚洲制服 视频在线观看| 7777奇米成人狠狠成人影视| 强行糟蹋人妻hd中文| 日本高清视频www| 国产精品一区二区av片| 18女下面流水不遮图| 欧美内射深插日本少妇|