在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Cis-aconitate decarboxylase (Acod1)

Recombinant Mouse Cis-aconitate decarboxylase (Acod1)

  • 中文名稱：
    Recombinant Mouse Cis-aconitate decarboxylase(Acod1)
  • 貨號：
    CSB-YP011825MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cis-aconitate decarboxylase(Acod1)
  • 貨號：
    CSB-EP011825MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cis-aconitate decarboxylase(Acod1)
  • 貨號：
    CSB-MP011825MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Acod1
  • Uniprot No.：
  • 別名：
    Acod1; Irg1Cis-aconitate decarboxylase; CAD; EC 4.1.1.6; Aconitate decarboxylase; Aconitate decarboxylase 1; Cis-aconitic acid decarboxylase; Immune-responsive gene 1 protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-488
  • 氨基酸序列
    MMLKSVTESF AGMIHGLKVN HLTDGIIRRS KRMILDSLGV GFLGTGTEVF HKVTQYSKIY SSNTSSTVWG RPDFRLPPTY AAFVNGVAVH SMDFDDTWHP ATHPSGAVLP VLTALSEALP QIPKFSGLDL LLAFNVGIEV QGRLMHFSKE AKDIPKRFHP PSVVGTLGSA AAASKFLGLS LTKCREALAI AVSHAGAPIA NAATQTKPLH IGNAAKHGME ATFLAMLGLQ GNKQILDLGS GFGAFYANYS PEDLPSLDSH IWLLDQQDVA FKSFPAHLAT HWVADAAAAV RKHLVTPERA LFPADHIERI VLRIPDVQYV NRPFPDSEHE ARHSFQYVAC ASLLDGSITV PSFHSQQVNR PQVRELLKKV KLEHPPDNPP SFDTLYCEIS ITLKDGTTFT ERSDTFYGHW RKPLSQEDLR NKFRANASKM LCRDTVESLI TVVEKLEDLE DCSVLTRLLK GPSVQDEASK LSSMSSFDHT TLPRFTNI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.
  • 基因功能參考文獻：
    1. Loss of itaconate production in activated macrophages from Irg1(-/-) mice decreases the accumulation of succinate in response to LPS exposure PMID: 27189937
    2. LPS-stimulated TNF-alpha was significantly decreased, whereas IRG1 and A20 were increased by CORM-2 application and HO-1 induction, which in turn were abrogated by ZnPP. PMID: 25640654
    3. inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxin tolerance. PMID: 23609450
    4. IRG1 links cellular metabolism with immune defense by catalyzing itaconic acid production PMID: 23610393
    5. show that the delayed but highly effective clearance of intrauterine Chlamydia trachomatis infections in Irgm1/m3((-/-)) mice is dependent on an exacerbated CD4(+) T cell response PMID: 21731484
    6. PKC pathway is induced in the uterine epithelium at implantation by the synergistic action of progesterone and estrogen and is responsible for the hormone induction of Irg1 PMID: 12893884
    7. Irg1 is a novel target of progesterone receptor in the pregnant uterus and also revealed that it is a critical regulator of the early events leading to implantation. PMID: 14500577
    8. Thus, our data demonstrate that transcriptional and post-transcriptional mechanisms are responsible for a differential IRG1 gene expression in murine macrophages treated with LPS, MAP, and M. smegmatis. PMID: 16415166
    9. IRG1 is highly upregulated in murine ANA-1 macrophages by several proinflammatory cytokines and Toll-like receptor (TLR) agonists, as well as in spleen and lung of Listeria monocytogenes or Toxoplasma gondii infected mice, respectively PMID: 19014335

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    PrpD family
  • 組織特異性：
    Expressed in LPS-tolerized macrophages (at protein level). Expressed in the luminal epithelial cells of pregnant uterus. Expressed in microglia and macrophage cells.
  • 數據庫鏈接：


主站蜘蛛池模板： 久久青青草原精品国产app| 欧美在线精彩视频免费播放 | 中文字幕人妻无码一夲道| 国产成人无码av在线播放dvd| 国产精品多p对白交换绿帽| 久艹视频免费看| 丰满多毛的陰户视频| 国产欧美日韩精品专区| 内射精品无码中文字幕| 99re6在线视频精品免费| 青青草av一区二区三区| 天堂а√中文在线| 国产欧美日韩精品丝袜高跟鞋| 情侣做性视频在线播放| 美女裸体自慰在线观看| 精品第一国产综合精品蜜芽| 日本高清色本在线www| 亚洲美女又黄又爽在线观看| 亚洲国产午夜精品理论片在线播放| 无码熟熟妇丰满人妻啪啪| 亚洲精品国产自在现线最新| 5858s亚洲色大成网站www| 色翁荡息又大又硬又粗又爽电影| 色噜噜狠狠色综合网| 男女啪啪激烈高潮喷出gif免费| 亚洲国产一区二区三区波多野结衣 | 亚洲一区二区制服在线| 国产成+人+综合+亚洲专区| 久久一日本综合色鬼综合色| 中文字幕日韩一区二区三区不卡| 成人无遮羞视频在线观看| 国产精品星空无限传媒| 97在线成人国产在线视频| 亚洲理论在线a中文字幕| 精品一卡2卡3卡4卡新区在线 | 久久亚洲欧美国产精品| 久久无码字幕中文久久无码| 中文字幕在线观看亚洲日韩| 欧美激情猛片xxxⅹ大3| 成人午夜亚洲精品无码区| 免费人成在线观看视频播放|