在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Caspase-6 (Casp6)

Recombinant Mouse Caspase-6 (Casp6)

  • 中文名稱：
    Recombinant Mouse Caspase-6(Casp6)
  • 貨號：
    CSB-YP004551MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Caspase-6(Casp6)
  • 貨號：
    CSB-EP004551MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Caspase-6(Casp6)
  • 貨號：
    CSB-EP004551MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Caspase-6(Casp6)
  • 貨號：
    CSB-BP004551MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Caspase-6(Casp6)
  • 貨號：
    CSB-MP004551MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Casp6Caspase-6; CASP-6; EC 3.4.22.59; Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    6-162
  • 氨基酸序列
    GFYKS REVFDPAEQY KMDHKRRGVA LIFNHERFFW HLTLPERRGT NADRDNLTRR FSDLGFEVKC FNDLRAEELL LKIHEVSTSS HIDADCFICV FLSHGEGNHV YAYDAKIEIQ TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ HDVPVVPLDM VD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity. During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation. Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP. Cleaves phospholipid scramblase proteins XKR4 and XKR9. Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis. Regulates B-cell programs both during early development and after antigen stimulation. In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses. Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death.
  • 基因功能參考文獻：
    1. Intact motor axons of Casp6 null mice had normal electrophysiological properties but, as tested serially during axonal degeneration (AxD), there was attenuated loss of excitability. Following transection, morphological features of AxD were evident in both wild type and Casp6-/- mice but the latter had evidence of slowed progression. PMID: 29229552
    2. Caspase-6 is posttranslationally palmitoylated by the palmitoyl acyltransferase HIP14 and that the palmitoylation of Caspase-6 inhibits its activation. PMID: 27911442
    3. The bactericidal activity of caspase-6-/- macrophages was impaired compared to wild type cells. Caspase-6-/- mice showed higher expression of the IL-1b gene, known to be detrimental in murine melioidosis. Expression of the IL-10 gene was also increased in caspase-6-/- mice as early as 6 hours after infection. Treatment with exogenous IL-10 rendered mice more susceptible against B. pseudomallei challenge PMID: 28686630
    4. caspase-6 could regulate breast cancer cell invasion by modulating MMP-2 and MMP-9 expression in 4T1 tumor-associated macrophages PMID: 27325699
    5. Casp6 is unlikely to be involved in colitis-associated tumors. PMID: 25470254
    6. p53 activity is an important upstream regulator of caspase-6 activity in muscle tissue. PMID: 24070868
    7. TNFalpha-induced RIP1-independent caspase-6 activation was involved in regulating the relationship between autophagy and necroptosis. PMID: 23941769
    8. CASP6 released from axonal terminals regulates microglial TNF-alpha secretion, synaptic plasticity, and inflammatory pain. PMID: 24531553
    9. Casp6-/- neurons are protected against excitotoxicity, nerve growth factor deprivation and myelin-induced axonal degeneration. Furthermore, Casp6-deficient mice show an age-dependent increase in cortical and striatal volume. PMID: 22262731
    10. This study demonistrated that elimination of caspase-6 protein and activity in the BACHD mouse model does not prevent the production of a 586 aa Htt proteolytic fragment in the brain. PMID: 22649225
    11. Neutrophil/macrophage contact activates CASP-6, producing interleukin-1 receptor-associated kinase-M (IRAK-M) cleavage and de-repression of alveolar macrophages; CASP-6 deletion protects mice from death caused by bacterial peritonitis. PMID: 21098228
    12. Lamin A/C and caspase-6 could be valuable tools in the knowledge of oocyte in vitro destiny PMID: 20130288
    13. p53 activation enhances XIAP inhibition-induced cell death by promoting mitochondrial release of second mitochondria-derived activator of caspases (SMAC) and by inducing the expression of caspase-6. PMID: 19897582
    14. CREB-binding proteins are specifically targeted by caspases and calpains at the onset of neuronal apoptosis PMID: 14657026
    15. caspase-6 and caspase-7 are activated by teratogens in early postimplantation mouse embryos PMID: 14686614
    16. Taken together, these results suggest that activation of caspases (6 and 7) and the subsequent cleavage of lamin A/C and PARP are involved in the morphological changes of apoptotic macrophages infected with Actinobacillus actinomycetemcomitans. PMID: 17893180
    17. Casp6 may regulate both B cell activation and differentiation PMID: 18981099
    18. results indicate that APP and DR6 are components of a neuronal self-destruction pathway, and suggest that an extracellular fragment of APP, acting via DR6 and caspase 6, contributes to Alzheimer's disease PMID: 19225519

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C14A family
  • 組織特異性：
    Highly expressed in lung, liver, kidney, testis, and heart. Lower levels in spleen, skeletal muscle and brain. Expressed in neurons.
  • 數據庫鏈接：


主站蜘蛛池模板： 成人av无码一区二区三区| 色综合 图片区 小说区| 人人爽久久涩噜噜噜av| 色一情一伦一区二区三| 变态另类牲交乱| 国产精品区一区二区三在线播放| 日韩精品一卡2卡3卡4卡新区视频| 亚洲国产精品久久久久久久| 揉着我的奶从后面进去视频| 国精品无码一区二区三区左线| 久久99精品久久久久久| 国产精品99久久免费黑人人妻| 久久精品动漫一区二区三区| 亚洲国产制服丝袜无码av| 国产成人国拍亚洲精品| 国产好大好硬好爽免费视频| 亚洲区小说区图片区qvod| 轻点好疼好大好爽视频| 蜜桃视频一区二区在线观看| 狠狠躁日日躁夜夜躁2022麻豆| 麻豆自媒体 一区 二区| 无码纯肉动漫在线观看| 欧美男男大粗吊1069| 久久婷婷色综合一区二区| 国产精品538一区二区在线| 伊人成年网站综合网| 国产av久久久久精东av| 国产成年码av片在线观看| 久久精品国产久精国产爱 | 18禁黄无遮挡网站| 久久人人爽人人爽人人片av不| 成人性做爰aaa片免费| 亚洲欧美中文日韩在线v日本 | 亚洲日韩成人av无码网站| 日韩人妻无码精品免费shipin| 亚洲乱色伦图片区小说| 加勒比色综合久久久久久久久| 任你躁x7x7x7x7在线观看| 午夜福利麻豆国产精品| 人妻熟女久久久久久久| 免费无码黄网站在线看|