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CASP6

胱天蛋白酶6(CASP6)是一種參與細胞凋亡的蛋白酶,在神經退行性疾病的發生發展中發揮重要作用。CASP6 的全稱是胱天蛋白酶6,常見別名包括 MCH2、CASP 6 等。CASP6 通過切割多種底物,如聚(ADP-核糖)聚合物、層蛋白等,參與細胞凋亡的執行階段。研究表明,CASP6 在亨廷頓舞蹈癥和阿爾茨海默病的細胞凋亡、早期免疫反應和神經變性中發揮重要作用。CASP6 的異常激活與神經退行性疾病的神經元過度死亡有關,因此成為治療這些疾病的重要靶點。目前,針對 CASP6 的藥物研發正在積極進行中,包括開發 CASP6 抑制劑等,以期通過抑制 CASP6 的活性,減少神經炎癥和神經元死亡,從而治療神經退行性疾病。

熱銷產品

CASP6 Recombinant Monoclonal Antibody (CSB-RA065800A0HU)

驗證數據

CSB-RA065800A0HU

Western Blot
Positive WB detected in: K562 whole cell lysate(30μg)
All lanes: Caspase 6 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 34 kDa
Observed band size: 34 kDa
Exposure time:2min

CSB-RA065800A0HU

Immunofluorescence staining of PC-3 cell with CSB-RA065800A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA065800A0HU

Overlay Peak curve showing jurkat cells stained with CSB-RA065800A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CASP6 Antibodies

CASP6 for Homo sapiens (Human)

CASP6 for Mus musculus (Mouse)

CASP6 Proteins

CASP6 Proteins for Homo sapiens (Human)

CASP6 Proteins for Mus musculus (Mouse)

CASP6 Proteins for Rattus norvegicus (Rat)

CASP6 Proteins for Bos taurus (Bovine)



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