在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse COP9 signalosome complex subunit 2 (Cops2)

  • 中文名稱:
    Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
  • 貨號:
    CSB-YP005789MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
  • 貨號:
    CSB-EP005789MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
  • 貨號:
    CSB-EP005789MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
  • 貨號:
    CSB-BP005789MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
  • 貨號:
    CSB-MP005789MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Cops2
  • Uniprot No.:
  • 別名:
    Cops2; Csn2; Trip15COP9 signalosome complex subunit 2; SGN2; Signalosome subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-443
  • 氨基酸序列
    MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
  • 基因功能參考文獻:
    1. Cops2, but not the whole COP9 signalosome, is essential for pluripotency maintenance in mouse embryonic stem cells. Down-regulation of Cops2 reduces expression of pluripotency genes, slows proliferation rate, arrests G2/M cell cycle, and compromises ESC embryoid differentiation. Cops2 binds to Nanog protein and prevents degradation. Cops2 functions as transcriptional corepressor to facilitate pluripotency maintenance. PMID: 27226076
    2. these data indicate that Alien/ESET complex is involved in TRbeta1-mediated transcription repression of E2F1 and provide a molecular basis of thyroid hormone-induced repression of proliferation. PMID: 22079090
    3. Nif3l1 participates in neural differentiation of P19 cells through cooperation with Trip15/CSN2. PMID: 12522100
    4. Expressed at an early stage of neuronal differentiation of P19 embryonal carcinoma cells. PMID: 12524175
    5. Disruption of Cops2 causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. PMID: 12972599

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    CSN2 family
  • 組織特異性:
    Widely expressed in embryonic, fetal and adult tissues, except cartilage and smooth muscle.
  • 數據庫鏈接:


主站蜘蛛池模板: 伊人激情av一区二区三区| 人妻被按摩到潮喷中文不卡| 少妇高潮太爽了在线观看欧美| 久久久无码精品亚洲日韩按摩 | 中文字幕无码一区二区免费| 天天燥日日燥| 四虎影在永久在线观看| 亚洲嫩模喷白浆在线观看| 337p粉嫩大胆色噜噜噜| 欧美成人看片黄a免费看| 亚洲精品无码久久千人斩| 成人免费无码不卡毛片| 亚洲中文无码人a∨在线| 国产做a爰片久久毛片a片| 亚洲国产成人一区二区精品区| 国产成人亚洲精品无码电影| 最新在线精品国产福利| 中文字幕亚洲综合久久菠萝蜜| 国产精品国产三级在线专区| 草草久久97超级碰碰碰| 亚洲 综合 自拍 精品 在线| 国产欧美日韩一区二区三区| 国产亚洲精品久久久久久大师| 国产精品人妻系列21p| 久久精品人人做人人爱爱漫画 | 免费午夜男女高清视频| 久久国产欧美日韩精品| 无码人妻丰满熟妇啪啪7774| 国产片免费福利片永久| 欧美性色黄大片手机版| 国产人妻人伦精品1国产 | 国产午夜人做人免费视频网站| 亚洲国产果冻传媒av在线观看| 日本中国内射bbxx| 无码av免费一区二区三区a片| 少妇精品揄拍高潮少妇| 日韩欧美猛交xxxxx无码| 亚洲欧洲日本无在线码| 国产成人午夜在线视频a站| 亚洲欧洲精品成人久久曰| 久久视频在线视频|