在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Bis (5'-adenosyl)-triphosphatase (Fhit)

Recombinant Mouse Bis (5'-adenosyl)-triphosphatase (Fhit)

In Stock
  • 中文名稱：
    小鼠Fhit重組蛋白
  • 貨號(hào)：
    CSB-EP530819MO
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Fhit
  • Uniprot No.：
  • 別名：
    FhitBis(5'-adenosyl)-triphosphatase; EC 3.6.1.29; AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 來(lái)源：
    E.coli
  • 分子量：
    21.1kDa
  • 表達(dá)區(qū)域：
    2-150aa
  • 氨基酸序列
    SFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQTVKHVHVHVLPRKAGDFPRNDNIYDELQKHDREEEDSPAFWRSEKEMAAEAEALRVYFQA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate. Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity. Functions as tumor suppressor.
  • 基因功能參考文獻(xiàn)：
    1. Fhit loss and subsequent thymidine kinase 1 inactivation, combined with selective pressures, leads to neoplasia-associated alterations in genes and gene expression patterns in vitro and in vivo PMID: 27513973
    2. Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient. PMID: 26782170
    3. Fhit deficiency-induced global genome instability promotes mutation and clonal expansion PMID: 24244712
    4. Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. PMID: 24223161
    5. FHIT gene is a "caretaker gene" necessary for maintenance of genome stability. PMID: 23929738
    6. Loss of Fhit expression contributes to cell transformation. PMID: 23102829
    7. Defects in Fhit expression may promote MHC-I down-regulation in cancer cells and allow escape from immunosurveillance. PMID: 22451343
    8. Human and mouse orthologous genes, FHIT and Fhit, are more highly conserved through evolution than PTPRG/Ptprg and yet contain more sequence elements that are exquisitely sensitive to genomic rearrangements PMID: 14630947
    9. Fhit has a role in bladder cancer development PMID: 15569992
    10. UV-induced alterations of the FHIT and WWOX fragile site gene expression are involved at least partially in the checkpoint function of DNA damage PMID: 15798093
    11. Data suggest that heterozygosity for FHIT affects susceptibility of mice to spontaneous alopecia areata and benzo[a]pyrene-induced preneoplastic lesions of the uterus and does not alter responsiveness to budesonide and N-acetyl-L-cysteine. PMID: 16672365
    12. Nit1 and Fhit share tumor suppressor signaling pathways, while localization of the NIT1 gene at a stable chromosome site explains the paucity of gene alterations and in frequent loss of expression of the NIT1 gene in human malignancies. PMID: 16864578
    13. It is likely that the FHIT transgene is more tightly silenced in female transgenic mice, leading to a lack of protection from tumor induction PMID: 18000371
    14. tumor-like microdeletions in FHIT/FRA3B are induced by replication stress PMID: 18162546
    15. reduced oxidative stress, coupled with efficient but not error-free DNA damage repair, allows unscheduled long-term survival of genotoxin-exposed Fhit-deficient hematopoietic stem cells carrying deleterious mutations PMID: 18483248
    16. the extent of tumor susceptibility due to Nit1 and Fhit deficiency is additive PMID: 19479888

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Mitochondrion.
  • 組織特異性：
    Expressed in heart, brain, lung and skeletal muscle. Particularly strong expression in liver, testis and kidney, where it is confined to the tubular epithelium.
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 无码av永久免费专区麻豆| 怀孕挺大肚子疯狂高潮av毛片| 无码人妻在线一区二区三区免费| 国产三级a三级三级| 综合无码一区二区三区| 日本丰满护士bbw| 国产内射在线激情一区| 国产精品久久久久久人妻精品| 强奷人妻日本中文字幕| 亚洲欧美国产另类va| 手机在线亚洲国产精品| 婷婷五月综合国产激情| 亚洲中文字幕无码久久| 欧美亚洲国产精品久久高清| 亚洲人成伊人成综合网中文 | 日韩乱码人妻无码系列中文字幕| 青草av久久一区二区三区| 国产黄在线观看免费观看软件| 无码av免费一区二区三区| 欧美黑人性暴力猛交喷水黑人巨大| 狠狠色老熟妇老熟女| 日本高清视频wwww色| 国产精品夜间视频香蕉| 国产成人 综合 亚洲欧洲| 把腿张开老子臊烂你多p视频 | 国产精品.xx视频.xxtv| 青青草国产精品日韩欧美| 男女裸交无遮挡啪啪激情试看| 久久人妻少妇嫩草av| 国产精品一区二区久久| 久久久久久99av无码免费网站| 欧美巨大黑人精品videos| 欧美又大又硬又粗bbbbb| 中文在线а√在线天堂中文| 亚洲欧洲精品无码av| 免费观看全黄做爰大片国产| 99久久精品美女高潮喷水| 100禁毛片免费40分钟视频| 亚洲日韩中文字幕在线播放 | 精品无码一区二区三区爱欲| 国产亚洲精品一区在线播放|