在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Fhit Antibody

Fhit Antibody

  • 中文名稱：
    Fhit兔多克隆抗體
  • 貨號：
    CSB-PA530819HA01MO
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Mus musculus (Mouse) Fhit Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Fhit
  • 別名：
    FhitBis(5'-adenosyl)-triphosphatase antibody; EC 3.6.1.29 antibody; AP3A hydrolase antibody; AP3Aase antibody; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase antibody; Dinucleosidetriphosphatase antibody; Fragile histidine triad protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Bis(5\'-adenosyl)-triphosphatase protein (2-150AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，Fhit Antibody (CSB-PA530819HA01MO)，的標記方式是Non-conjugated。對于Fhit Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA530819HB01MO Fhit Antibody, HRP conjugated ELISA
    FITC CSB-PA530819HC01MO Fhit Antibody, FITC conjugated
    Biotin CSB-PA530819HD01MO Fhit Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate. Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity. Functions as tumor suppressor.
  • 基因功能參考文獻：
    1. Fhit loss and subsequent thymidine kinase 1 inactivation, combined with selective pressures, leads to neoplasia-associated alterations in genes and gene expression patterns in vitro and in vivo PMID: 27513973
    2. Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient. PMID: 26782170
    3. Fhit deficiency-induced global genome instability promotes mutation and clonal expansion PMID: 24244712
    4. Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. PMID: 24223161
    5. FHIT gene is a "caretaker gene" necessary for maintenance of genome stability. PMID: 23929738
    6. Loss of Fhit expression contributes to cell transformation. PMID: 23102829
    7. Defects in Fhit expression may promote MHC-I down-regulation in cancer cells and allow escape from immunosurveillance. PMID: 22451343
    8. Human and mouse orthologous genes, FHIT and Fhit, are more highly conserved through evolution than PTPRG/Ptprg and yet contain more sequence elements that are exquisitely sensitive to genomic rearrangements PMID: 14630947
    9. Fhit has a role in bladder cancer development PMID: 15569992
    10. UV-induced alterations of the FHIT and WWOX fragile site gene expression are involved at least partially in the checkpoint function of DNA damage PMID: 15798093
    11. Data suggest that heterozygosity for FHIT affects susceptibility of mice to spontaneous alopecia areata and benzo[a]pyrene-induced preneoplastic lesions of the uterus and does not alter responsiveness to budesonide and N-acetyl-L-cysteine. PMID: 16672365
    12. Nit1 and Fhit share tumor suppressor signaling pathways, while localization of the NIT1 gene at a stable chromosome site explains the paucity of gene alterations and in frequent loss of expression of the NIT1 gene in human malignancies. PMID: 16864578
    13. It is likely that the FHIT transgene is more tightly silenced in female transgenic mice, leading to a lack of protection from tumor induction PMID: 18000371
    14. tumor-like microdeletions in FHIT/FRA3B are induced by replication stress PMID: 18162546
    15. reduced oxidative stress, coupled with efficient but not error-free DNA damage repair, allows unscheduled long-term survival of genotoxin-exposed Fhit-deficient hematopoietic stem cells carrying deleterious mutations PMID: 18483248
    16. the extent of tumor susceptibility due to Nit1 and Fhit deficiency is additive PMID: 19479888

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Mitochondrion.
  • 組織特異性：
    Expressed in heart, brain, lung and skeletal muscle. Particularly strong expression in liver, testis and kidney, where it is confined to the tubular epithelium.
  • 數據庫鏈接：


主站蜘蛛池模板： 久久婷婷六月综合色液啪| 国产精品视频免费播放| 天堂а在线中文在线新版| 国产成人免费永久在线平台| 丰满多毛的大隂户视频| 男男gv白嫩小受gv在线播放| 午夜免费无码福利视频| 爱情岛论坛网亚洲品质| 粗大猛烈进出高潮视频免费看| 狂野av人人澡人人添| 亚洲性色成人av| 69久久精品无码一区二区无码| 99国产精品久久久久久久成人热| 最大胆裸体人体牲交| 免费视频爱爱太爽了| 亚洲精品入口一区二区乱麻豆精品 | 亚洲 欧美日韩 综合 国产| 国产午夜亚洲精品不卡| 激情97综合亚洲色婷婷五| 夜夜躁狠狠躁日日躁视频| а天堂中文官网| 大香伊蕉在人线国产网站首页 | 白丝爆浆18禁一区二区三区| 久久久久久久久无码精品亚洲日韩| 国产综合精品| 人妻影音先锋啪啪av资源| 日韩吃奶摸下aa片免费观看| 日韩精品一区二区在线观看| 国产做爰xxxⅹ高潮视频12p| 亚洲成av人片在www鸭子| 自慰无码一区二区三区| 色婷婷久久久swag精品| 自拍偷亚洲产在线观看| 精品一区二区三区四区五区六区| 国产尤物精品视频| 欧洲一卡2卡3卡4卡国产| 亚洲色国产欧美日韩| 大肉大捧一进一出好爽视频| 动漫精品专区一区二区三区不卡| 日本三级带日本三级带黄| 精品无码国产一区二区三区麻豆|