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  4. Recombinant Mouse Beta-klotho (Klb), partial

Recombinant Mouse Beta-klotho (Klb), partial

  • 中文名稱：
    小鼠Klb重組蛋白
  • 貨號：
    CSB-YP859159MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Klb重組蛋白
  • 貨號：
    CSB-EP859159MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Klb重組蛋白
  • 貨號：
    CSB-EP859159MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Klb重組蛋白
  • 貨號：
    CSB-BP859159MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Klb重組蛋白
  • 貨號：
    CSB-MP859159MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Klb; BetaklBeta-klotho; BKL; BetaKlotho; Klotho beta-like protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
  • 基因功能參考文獻：
    1. Downregulation of beta-klotho expression is not the major mechanism of impaired FGF21 signaling in white adipose tissue. PMID: 28580290
    2. liver FGF21-betaKlotho pathway sufficient and necessary to repress mTOR/S6K activity PMID: 26926384
    3. The study supports a pro-adipogenic role for betaKlotho in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR-betaKlotho axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy. PMID: 26881702
    4. Data show that enhancing beta-klotho (KLB) expression in adipose may sensitize to endogenous fibroblast growth factor 21 (FGF21), thus representing a novel strategy to combat metabolic disease. PMID: 26901091
    5. beta-Kl in hepatocytes is necessary and sufficient for lipid homeostasis, whereas nonhepatic beta-Kl regulates energy metabolism. PMID: 26514166
    6. ATF4 signaling pathway is essential for mediating the effect of ER stress on beta-klotho expression. PMID: 25727012
    7. Klotho is a novel player in the retina, with a clear connection to photoreceptor cell death as well as with an influence on retinal organization. PMID: 23796581
    8. Mice lacking the FGF21 co-receptor, beta-Klotho, in the suprachiasmatic nucleus are refractory to the inhibitory effect of FGF21 on female fertility. PMID: 23933983
    9. The effects of FGF21 are mediated through beta-Klotho expression in the suprachiasmatic nucleus of the hypothalamus and the dorsal vagal complex of the hindbrain. PMID: 23933984
    10. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. PMID: 22958921
    11. demonstrate the first manifest evidence revealing that whereas alpha-Kl and beta-Kl are required for FGF23 and FGF15/hFGF19-mediated signaling pathways in vivo, respectively, beta-Kl appears not to be essential for FGF21-mediated signal transduction in vivo. PMID: 20080590
    12. KLB and FGFR1 form a 1:1 heterocomplex independent of the galectin lattice that transitions to a 1:2 complex upon the addition of FGF21. PMID: 22523080
    13. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PMID: 22442730
    14. In contrast to wild-type FGF23, FGF23-21c (a variant of FGF23 where the C-terminal domain of FGF23 was replaced with the corresponding regions from FGF21), FGF23-21c gained the ability to activate FGFR1c and FGFR2c in the presence of betaKlotho. PMID: 22370560
    15. function of Klotho family proteins PMID: 22396160
    16. These results indicate that betaKlotho and FGFRs form the cognate FGF-21 receptor complex, mediating FGF-21 cellular specificity and physiological effects. PMID: 18064602
    17. Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation. PMID: 20657013
    18. betaKlotho functions as a cofactor essential for fibroblast growth factor 21 activity PMID: 17452648
    19. Data suggested that betaKlotho expression is a crucial determinant of the FGF21 specificity of the target cells upon which it acts in an endocrine fashion. PMID: 18187602
    20. The results of this study indicate that both beta-Klotho and FGF-15/19 repress the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. PMID: 18772362

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  • 亞細胞定位：
    Cell membrane; Single-pass type III membrane protein.
  • 蛋白家族：
    Glycosyl hydrolase 1 family, Klotho subfamily
  • 組織特異性：
    Present in liver, muscle and white adipose tissue, but not in kidney (at protein level). Expressed in liver and pancreas, and at lower levels in skin, stomach, skeletal muscle, small intestine and lung.
  • 數據庫鏈接：


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