在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Macaca mulatta Interleukin-10 (IL10)

  • 中文名稱:
    獼猴IL10重組蛋白
  • 貨號:
    CSB-YP011580MOW
  • 規格:
    ¥2616
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    IL10Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
  • 種屬:
    Macaca mulatta (Rhesus macaque)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Yeast
  • 分子量:
    20.7kDa
  • 表達區域:
    19-178aa
  • 氨基酸序列
    SPGQGTQSENSCTRFPGNLPHMLRDLRDAFSRVKTFFQMKDQLDNILLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHDPDIKEHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFSKLQEKGVYKAMSEFDIFINYIEAYMTMKIQN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
  • 基因功能參考文獻:
    1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria. PMID: 24670425
    2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis. PMID: 25165117
    3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha cytokine production. PMID: 23867612
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    IL-10 family
  • 數據庫鏈接:


主站蜘蛛池模板: 日韩综合亚洲色在线影院| 亚洲性人人天天夜夜摸18禁止 | 久久好在线视频| 无码国产精成人午夜视频| 国产 | 欧洲野花视频天堂视频p| 精品国偷自产在线视频| 天堂www中文在线资源| 97人妻人人揉人人躁人人| 精品一卡二卡三卡| 国产亚洲精品第一综合不卡| 国产成人啪精品视频免费视频| 2019午夜福利不卡片在线| 精品国产av一二三四区| 亚洲无线码在线一区观看| 直接观看黄网站免费视频| 国产亚洲精品久久综合阿香| 精品国产午夜理论片不卡精品| 亚洲国产精品美女久久久久| 无码人妻丰满熟妇啪啪| 妺妺窝人体色777777| 国产美女a做受大片观看| 无码人妻日韩一区日韩二区| 四虎永久在线精品免费一区二区| 亚洲免费观看在线视频| 99久久精品国产一区二区三区| 亚洲伊人久久大香线蕉| 亚洲va在线va天堂va欧美va| 无码日韩做暖暖大全免费不卡| 久久这里只有精品首页| 狠狠色综合网站久久久久久久| 亚洲综合狠狠丁香五月| 日韩人妻无码精品专区综合网| 国产成人小说视频在线观看| 亚洲乱亚洲乱妇50p| 无码人妻一区二区三区免费视频| 国精品午夜福利视频| 免费看小12萝裸体视频国产| 精品久久综合1区2区3区激情| 国产精品永久免费视频| 国产精品亚洲欧美大片在线观看| 欧美va久久久噜噜噜久久|