在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Macaca mulatta Interleukin-10 (IL10)

In Stock
  • 中文名稱:
    獼猴IL10重組蛋白
  • 貨號:
    CSB-MP011580MOW
  • 規格:
    ¥1140
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    IL10Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
  • 種屬:
    Macaca mulatta (Rhesus macaque)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Mammalian cell
  • 分子量:
    20.7kDa
  • 表達區域:
    19-178aa
  • 氨基酸序列
    SPGQGTQSENSCTRFPGNLPHMLRDLRDAFSRVKTFFQMKDQLDNILLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHDPDIKEHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFSKLQEKGVYKAMSEFDIFINYIEAYMTMKIQN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述:

    This Recombinant Macaca mulatta IL10 protein was made through genetic engineering. By putting the IL10 gene into the genetic material of Mammalian cell cell, the Mammalian cell could be used as factories or producers to make the desired IL10 protein for research uses. The expression region of this protein is at 19-178aa. C-terminal 10xHis tag was used in the expression process. The purity is 85%+ determined by SDS-PAGE.

    IL-10 is the founding member of a family of cytokines. The involvement of IL-10 in many disease states has been demonstrated, both in animal models and in humans with mutations in the IL-10/IL-10R axis. IL-10 was discovered 30 yr ago as a secreted cytokine synthesis inhibitory factor, produced by T helper (Th) 2 cell clones shown to inhibit cytokine production by Th1 cells. IL10–mediated inhibition of IFN-γ secretion by Th1 cells was demonstrated to occur via its action on the APC function of macrophages and by its inhibition of cytokine production by activated macrophages and dendritic cells. Additionally, IL-10 inhibited the killing of intracellular pathogens. The role of IL-10 clearly exceeds the regulation of intestinal inflammation, as a function for this molecule has been also described in several other settings, from inflammatory or neurodegenerative diseases to infection or cancer. In summary, IL-10 has emerged as a major suppressor of the immune response and a key player in human disease, and is thus an attractive therapeutic target.

  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
  • 基因功能參考文獻:
    1. IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria. PMID: 24670425
    2. Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis. PMID: 25165117
    3. IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha cytokine production. PMID: 23867612
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    IL-10 family
  • 數據庫鏈接:


主站蜘蛛池模板: 国产午夜成人av在线播放| 国产精品久久久久久av福利| 成人国产精品秘片多多| 国产成人无码午夜视频在线观看| 久久国语露脸国产精品电影| 久久精品中文字幕一区二区三区| 亚洲国产综合av在线观看 | 国产午夜亚洲精品一区| 制服丝袜亚洲欧美中文字幕| 国产偷国产偷亚洲清高app| 日日天干夜夜狠狠爱| 欧美激情在线播放| 精品人妻伦九区久久aaa片69| 国产亚洲精品福利在线无卡一| 久久国产精品2020免费| 2020久热爱精品视频在线观看| 欧美牲交40_50a欧美牲交aⅴ| 国产成人无码专区| 99在线精品视频在线观看| 国产成人片无码免费视频软件 | 免费观看又色又爽又黄的崩锅| 未满十八勿入av网免费| 欧美丰满熟妇xxxx性ppx人| 久久婷婷五月综合色国产| 免费观看激色视频网站| 精品麻豆丝袜高跟鞋av| 欧美天天拍在线视频| 欧美午夜一区二区福利视频| 亚洲熟女综合一区二区三区| 性国产牲交xxxxx视频| 香港三级日本三级韩级人妇| 精品国产天线2019| 中文字幕aⅴ人妻一区二区 | 337p人体粉嫩胞高清视频| 国产成人影院一区二区三区| 69国产成人精品午夜福中文| 欧美老熟妇欲乱高清视频| 国产精品一区二区在线观看| 女学生14毛片视频片二毛| 亚洲成 人 综合 亚洲欧洲| 国产乱人伦偷精品视频不卡|