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  4. Recombinant Human respiratory syncytial virus B Nucleoprotein (N)

Recombinant Human respiratory syncytial virus B Nucleoprotein (N)

  • 中文名稱：
    Recombinant Human respiratory syncytial virus B Nucleoprotein(N)
  • 貨號：
    CSB-YP523629HXK
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human respiratory syncytial virus B Nucleoprotein(N)
  • 貨號：
    CSB-EP523629HXK
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human respiratory syncytial virus B Nucleoprotein(N)
  • 貨號：
    CSB-EP523629HXK-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human respiratory syncytial virus B Nucleoprotein(N)
  • 貨號：
    CSB-BP523629HXK
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human respiratory syncytial virus B Nucleoprotein(N)
  • 貨號：
    CSB-MP523629HXK
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N
  • Uniprot No.：
  • 別名：
    NNucleoprotein; Protein N; Nucleocapsid protein
  • 種屬：
    Human respiratory syncytial virus B (strain B1)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-391
  • 氨基酸序列
    MALSKVKLND TLNKDQLLSS SKYTIQRSTG DNIDTPNYDV QKHLNKLCGM LLITEDANHK FTGLIGMLYA MSRLGREDTI KILKDAGYHV KANGVDITTY RQDINGKEMK FEVLTLSSLT SEIQVNIEIE SRKSYKKMLK EMGEVAPEYR HDSPDCGMII LCIAALVITK LAAGDRSGLT AVIRRANNVL KNEIKRYKGL IPKDIANSFY EVFEKHPHLI DVFVHFGIAQ SSTRGGSRVE GIFAGLFMNA YGSGQVMLRW GVLAKSVKNI MLGHASVQAE MEQVVEVYEY AQKLGGEAGF YHILNNPKAS LLSLTQFPNF SSVVLGNAAG LGIMGEYRGT PRNQDLYDAA KAYAEQLKEN GVINYSVLDL TAEELEAIKN QLNPKEDDVE L
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway. May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs.
  • 基因功能參考文獻：
    1. The C-terminal residues of P with N constitutes a protein-protein interaction hotspot. PMID: 25407889
    2. Using a series of P fragments, authors determined by glutathione S-transferase (GST) pulldown assays that the N and C termini of P are able to interact with N(mono). PMID: 25568210
    3. nucleoprotein interacts with cellular arginine methyl-transferase, methylosome protein and Hsp70. PMID: 23892143
    4. Authors now unambiguously show that the respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid. PMID: 23677789
    5. In this study, glutathione S-transferase (GST) pulldown assays were used to identify the N-terminal core domain of human respiratory syncytial virus N (N(NTD)) as a P binding domain. PMID: 22623798
    6. Thus, Y38 phosphorylation of the human respiratory syncytial virus N protein modulates nucleocapsid template activity probably by altering the interactions of the monomeric components of the nucleocapsid. PMID: 22019509
    7. details of the inter-ring contacts in one crystal form revealed here suggest a basis for helical packing and that the stabilization of native human respiratory syncytial virus nucleocapsid is via mainly ionic interactions PMID: 22102022

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  • 亞細胞定位：
    Virion. Host cytoplasm.
  • 蛋白家族：
    Paramyxoviruses nucleocapsid family
  • 數據庫鏈接：

    KEGG: vg:1489820



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