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  4. Recombinant Human adenovirus C serotype 2 E1B protein, small T-antigen (E1B)

Recombinant Human adenovirus C serotype 2 E1B protein, small T-antigen (E1B)

  • 中文名稱：
    Recombinant Human adenovirus C serotype 2 E1B protein, small T-antigen(E1B)
  • 貨號：
    CSB-YP360999HIK
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human adenovirus C serotype 2 E1B protein, small T-antigen(E1B)
  • 貨號：
    CSB-EP360999HIK
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human adenovirus C serotype 2 E1B protein, small T-antigen(E1B)
  • 貨號：
    CSB-EP360999HIK-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human adenovirus C serotype 2 E1B protein, small T-antigen(E1B)
  • 貨號：
    CSB-BP360999HIK
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human adenovirus C serotype 2 E1B protein, small T-antigen(E1B)
  • 貨號：
    CSB-MP360999HIK
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    E1B
  • Uniprot No.：
  • 別名：
    E1BE1B protein; small T-antigen; E1B 19 kDa protein; E1B-19K; E1B-175R
  • 種屬：
    Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-175
  • 氨基酸序列
    MEAWECLEDF SAVRNLLEQS SNSTSWFWRF LWGSSQAKLV CRIKEDYKWE FEELLKSCGE LFDSLNLGHQ ALFQEKVIKT LDFSTPGRAA AAVAFLSFIK DKWSEETHLS GGYLLDFLAM HLWRAVVRHK NRLLLLSSVR PAIIPTEEQQ QEEARRRRRQ EQSPWNPRAG LDPRE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates.
  • 基因功能參考文獻：
    1. KAP1 binds to the viral E1B-55K protein, promoting its SUMO modification, therefore illustrating a crucial step for efficient viral replication. PMID: 26537675
    2. The adenoviral E1B-55K protein prevents entry into mitosis. PMID: 25694601
    3. The E1B-55K or E4orf3 proteins independently prevented nuclear fragmentation subsequent to release of AIF from the mitochondria, possibly by altering the intracellular distribution of PAR-modified proteins. PMID: 24889240
    4. E3/19K transmembrane domain acts as a signal for static ER retention that significantly enhances HLA complex formation.. PMID: 23514889
    5. E1B55K is not required for efficient degradation of nuclear substrates. PMID: 23408624
    6. The E2 enzyme Ubc9 is an interaction partner of E1B-55K, providing a possible molecular explanation for SUMO-dependent modulation of cellular target proteins. PMID: 22614022
    7. These observations indicate that the E1B 55-kDa protein is not sufficient to establish transcriptional repression of interferon-inducible genes. PMID: 23388716
    8. Timely synthesis of the E1B protein is required for efficient genome replication in normal human cells. PMID: 22278242
    9. The human adenovirus type 5 E1B protein is phosphorylated by protein kinase CK2. PMID: 22190719
    10. These results provide evidence for the idea that SUMO-1-conjugated E1B-55K-mediated degradation of Daxx plays a key role in adenoviral oncogenic transformation. PMID: 21697482
    11. results illustrate importance of Daxx in adenovirus virus growth restriction and suggest E1B-55K antagonizes innate antiviral activities of Daxx and promyelocytic leukemia protein nuclear bodies to stimulate viral replication at a posttranslational level PMID: 20484509
    12. E3/19K has a dual function: inhibition of T-cell recognition and NK cell activation. PMID: 18287244
    13. These results indicate that the E1B protein fulfills an early function that correlates efficient entry into the late phase with the localization of E1B and p53 in the nucleus of Ad5-infected normal human cells. PMID: 18632130
    14. Statistical analysis of the enrichment of genes associated with specific functions in these clusters established that the E1B 55-kDa protein is necessary for repression of genes encoding proteins that mediate antiviral and immune defenses. PMID: 19211769
    15. the E1B-55K/E4orf6 complex has a role in viral late protein synthesis and shows the existence of multiple layers of regulation imposed on eIF2alpha phosphorylation and PKR activation in adenovirus-infected cells PMID: 19605483

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  • 亞細胞定位：
    Host cell membrane. Host nucleus envelope. Host nucleus lamina.
  • 蛋白家族：
    Adenoviridae E1B 19 kDa protein family


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