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  4. Recombinant Human Zinc finger FYVE domain-containing protein 9 (ZFYVE9), partial

Recombinant Human Zinc finger FYVE domain-containing protein 9 (ZFYVE9), partial

  • 中文名稱：
    人ZFYVE9重組蛋白
  • 貨號：
    CSB-YP026477HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ZFYVE9重組蛋白
  • 貨號：
    CSB-EP026477HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ZFYVE9重組蛋白
  • 貨號：
    CSB-EP026477HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ZFYVE9重組蛋白
  • 貨號：
    CSB-BP026477HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ZFYVE9重組蛋白
  • 貨號：
    CSB-MP026477HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CG15667; hSARA; LD33044p; Madh-interacting protein; MADHIP; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; Receptor activation anchor; SAR1; SARA; SARA1; Smad anchor for receptor activation; SMADIP; ZFYV9_HUMAN; ZFYVE9; Zinc finger FYVE domain-containing protein 9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
  • 基因功能參考文獻：
    1. we have identified endofin as an important signalling component required for basal and BMP-induced hepcidin expression. PMID: 26358513
    2. SARA may serve as a potential novel target in pre-Epithelial-mesenchymal transition states for the amelioration renal fibrosis seen in chronic kidney diseases PMID: 26159183
    3. PI3K-C2a was also required for TGFb receptor-mediated formation of SARA-Smad2/3 complex PMID: 25614622
    4. The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers. PMID: 23222715
    5. TGF-beta1 can induce epithelial-to-mesenchymal transition through reduction in SARA expression, SARA is also basally regulated by its interaction with PI3K. PMID: 22942286
    6. no correlation between SARA expression and the levels of TGF-beta1-induced phosphorylation of Smads in various B-cell lymphomas PMID: 22819827
    7. SARA binds to ERBIN using a new domain, which we have called the ERBID (ERBIN-binding domain) PMID: 21878490
    8. After stimulation with glucose, expression of SARA decreased in a time-dependent manner in epithelium to mesenchymal transition of proximal tubule cells. PMID: 21200089
    9. Expression of a SARA mutant protein lacking the FYVE finger inhibits downstream activin A signaling in endothelial cells. PMID: 11877415
    10. role in rab5 mediated endocytosis PMID: 12432064
    11. SARA MH2 domains function in TGF-beta signaling PMID: 15231848
    12. internalization is important for transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells PMID: 15613484
    13. SARA acts as a Smad anchor for receptor activation in BMP signaling. PMID: 17356069
    14. Protein-protein and protein-lipid interactions organized by SARA regulate the vesicular targeting of rhodopsin-bearing axonemal vesicles to nascent discs at the base of the rod outer segment. PMID: 17693260
    15. SARA has a role in regulating cell phenotype and its effects are mediated through modification of the balance between Smad2 and Smad3 signaling PMID: 19620243

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  • 亞細胞定位：
    Cytoplasm. Early endosome membrane.
  • 組織特異性：
    Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
  • 數據庫鏈接：

    HGNC: 6775

    OMIM: 603755

    KEGG: hsa:9372

    STRING: 9606.ENSP00000287727

    UniGene: Hs.532345



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