在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ZFYVE9 Antibody, Biotin conjugated

ZFYVE9 Antibody, Biotin conjugated

  • 中文名稱：
    ZFYVE9兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA026477LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ZFYVE9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CG15667 antibody; hSARA antibody; LD33044p antibody; Madh-interacting protein antibody; MADHIP antibody; Mothers against decapentaplegic homolog-interacting protein antibody; Novel serine protease antibody; NSP antibody; Receptor activation anchor antibody; SAR1 antibody; SARA antibody; SARA1 antibody; Smad anchor for receptor activation antibody; SMADIP antibody; ZFYV9_HUMAN antibody; ZFYVE9 antibody; Zinc finger FYVE domain-containing protein 9 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger FYVE domain-containing protein 9 protein (683-926AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
  • 基因功能參考文獻：
    1. we have identified endofin as an important signalling component required for basal and BMP-induced hepcidin expression. PMID: 26358513
    2. SARA may serve as a potential novel target in pre-Epithelial-mesenchymal transition states for the amelioration renal fibrosis seen in chronic kidney diseases PMID: 26159183
    3. PI3K-C2a was also required for TGFb receptor-mediated formation of SARA-Smad2/3 complex PMID: 25614622
    4. The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers. PMID: 23222715
    5. TGF-beta1 can induce epithelial-to-mesenchymal transition through reduction in SARA expression, SARA is also basally regulated by its interaction with PI3K. PMID: 22942286
    6. no correlation between SARA expression and the levels of TGF-beta1-induced phosphorylation of Smads in various B-cell lymphomas PMID: 22819827
    7. SARA binds to ERBIN using a new domain, which we have called the ERBID (ERBIN-binding domain) PMID: 21878490
    8. After stimulation with glucose, expression of SARA decreased in a time-dependent manner in epithelium to mesenchymal transition of proximal tubule cells. PMID: 21200089
    9. Expression of a SARA mutant protein lacking the FYVE finger inhibits downstream activin A signaling in endothelial cells. PMID: 11877415
    10. role in rab5 mediated endocytosis PMID: 12432064
    11. SARA MH2 domains function in TGF-beta signaling PMID: 15231848
    12. internalization is important for transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells PMID: 15613484
    13. SARA acts as a Smad anchor for receptor activation in BMP signaling. PMID: 17356069
    14. Protein-protein and protein-lipid interactions organized by SARA regulate the vesicular targeting of rhodopsin-bearing axonemal vesicles to nascent discs at the base of the rod outer segment. PMID: 17693260
    15. SARA has a role in regulating cell phenotype and its effects are mediated through modification of the balance between Smad2 and Smad3 signaling PMID: 19620243

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Early endosome membrane.
  • 組織特異性：
    Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
  • 數據庫鏈接：

    HGNC: 6775

    OMIM: 603755

    KEGG: hsa:9372

    STRING: 9606.ENSP00000287727

    UniGene: Hs.532345



主站蜘蛛池模板： 少妇挑战黑人高潮惨叫| 99精品久久毛片a片| 99精品一区二区三区无码吞精| 乱熟女高潮一区二区在线| 久久99国产精品成人| 欧美乱大交aaaa片if| 五月天天天综合精品无码| 免费精品99久久国产综合精品| 天堂√最新版中文在线地址| 在线亚洲高清揄拍自拍一品区| 内谢少妇xxxxx8老少交| 无码播放一区二区三区| 国产精品自在欧美一区| 国产精品高清不卡在线播放| 欧美精品黑人粗大免费| 疯狂三人交性欧美| 人妻 日韩精品 中文字幕| 麻豆自媒体 一区 二区| 免费网站内射红桃视频| 欧美人与牲动交xxxx| 好吊视频一区二区三区| 亚洲精品久久久久久久观小说| 亚洲日本精品国产一区vr| 激情综合一区二区三区| 女的被弄到高潮娇喘喷水视频| 麻豆视传媒精品av| 欧美 日韩 国产 另类 图片区| 国产成人精品一区二区在线小狼| 图片区小说区激情区偷拍区| 国产精品欧美成人片| 天堂8在线天堂资源bt| av怡红院一区二区三区| av中文无码乱人伦在线观看| 高潮潮喷奶水飞溅视频无码| 精品午夜福利在线观看| 国产亚洲欧美另类一区二区| 国产精品视频观看裸模| 无码精品a∨在线观看中文| 人人妻人人澡人人爽欧美一区九九| 国产超碰人人做人人爽av| 国产老熟妇精品观看|