在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ZFYVE9 Antibody

  • 中文名稱:
    ZFYVE9兔多克隆抗體
  • 貨號:
    CSB-PA026477GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CG15667 antibody; hSARA antibody; LD33044p antibody; Madh-interacting protein antibody; MADHIP antibody; Mothers against decapentaplegic homolog-interacting protein antibody; Novel serine protease antibody; NSP antibody; Receptor activation anchor antibody; SAR1 antibody; SARA antibody; SARA1 antibody; Smad anchor for receptor activation antibody; SMADIP antibody; ZFYV9_HUMAN antibody; ZFYVE9 antibody; Zinc finger FYVE domain-containing protein 9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ZFYVE9
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
  • 基因功能參考文獻:
    1. we have identified endofin as an important signalling component required for basal and BMP-induced hepcidin expression. PMID: 26358513
    2. SARA may serve as a potential novel target in pre-Epithelial-mesenchymal transition states for the amelioration renal fibrosis seen in chronic kidney diseases PMID: 26159183
    3. PI3K-C2a was also required for TGFb receptor-mediated formation of SARA-Smad2/3 complex PMID: 25614622
    4. The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers. PMID: 23222715
    5. TGF-beta1 can induce epithelial-to-mesenchymal transition through reduction in SARA expression, SARA is also basally regulated by its interaction with PI3K. PMID: 22942286
    6. no correlation between SARA expression and the levels of TGF-beta1-induced phosphorylation of Smads in various B-cell lymphomas PMID: 22819827
    7. SARA binds to ERBIN using a new domain, which we have called the ERBID (ERBIN-binding domain) PMID: 21878490
    8. After stimulation with glucose, expression of SARA decreased in a time-dependent manner in epithelium to mesenchymal transition of proximal tubule cells. PMID: 21200089
    9. Expression of a SARA mutant protein lacking the FYVE finger inhibits downstream activin A signaling in endothelial cells. PMID: 11877415
    10. role in rab5 mediated endocytosis PMID: 12432064
    11. SARA MH2 domains function in TGF-beta signaling PMID: 15231848
    12. internalization is important for transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells PMID: 15613484
    13. SARA acts as a Smad anchor for receptor activation in BMP signaling. PMID: 17356069
    14. Protein-protein and protein-lipid interactions organized by SARA regulate the vesicular targeting of rhodopsin-bearing axonemal vesicles to nascent discs at the base of the rod outer segment. PMID: 17693260
    15. SARA has a role in regulating cell phenotype and its effects are mediated through modification of the balance between Smad2 and Smad3 signaling PMID: 19620243

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Early endosome membrane.
  • 組織特異性:
    Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
  • 數據庫鏈接:

    HGNC: 6775

    OMIM: 603755

    KEGG: hsa:9372

    STRING: 9606.ENSP00000287727

    UniGene: Hs.532345



主站蜘蛛池模板: 日韩精品一卡2卡3卡4卡新区视频| 亚洲啪啪综合av一区| 久久亚洲国产精品成人av秋霞| 无码国产偷倩在线播放| 天堂最新版资源网| 日本wv一本一道久久香蕉| 国产无遮挡又黄又爽网站| 亚洲永久无码7777kkk| 少妇极品熟妇人妻| 蜜桃av色偷偷av老熟女| 无码专区 丝袜美腿 制服师生| 97色伦97色伦国产欧美| 亚洲精品国偷拍自产在线麻豆| 一本无码久本草在线中文字幕dvd| 日本内射精品一区二区视频 | 国产精品一国产精品| 美女视频黄的全免费视频网站| 国产精品久久国产精麻豆99网站| 亚洲性猛交xxxx| 精品久久国产字幕高潮| 自拍区小说区图片区亚洲| 成人午夜免费无码区| 亚洲乱妇亚洲乱妇xinglu| 亚洲精品久久久久久久久久吃药| 欧美亚洲综合成人a∨在线 | 人与禽交av在线播放| 国产精品亚洲精品一区二区| 精品性影院一区二区三区内射 | 韩国国内大量揄拍精品视频| 风韵多水的老熟妇| 亚洲熟妇av日韩熟妇在线| 亚洲伊人久久综合成人| 久久精品国产精品亚洲38| 18禁黄网站男男禁片免费观看| 欧美日韩午夜群交多人轮换| 首页 综合国产 亚洲 丝袜| 2020久久超碰国产精品最新| 国产亚洲精品字幕在线观看| 国产成人亚洲精品| 欧美xxxx做受欧美69| av色综合久久天堂av色综合|