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  4. Recombinant Human Y+L amino acid transporter 1 (SLC7A7), partial

Recombinant Human Y+L amino acid transporter 1 (SLC7A7), partial

  • 中文名稱：
    人SLC7A7重組蛋白
  • 貨號：
    CSB-YP892349HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC7A7重組蛋白
  • 貨號：
    CSB-EP892349HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC7A7重組蛋白
  • 貨號：
    CSB-EP892349HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC7A7重組蛋白
  • 貨號：
    CSB-BP892349HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC7A7重組蛋白
  • 貨號：
    CSB-MP892349HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC7A7
  • Uniprot No.：
  • 別名：
    LAT3; LPI; Monocyte amino acid permease 2; MOP-2; MOP2; SLC7A 7; Slc7a7; Solute carrier family 7 (cationic amino acid transporter; y+ system); member 7 ; Solute carrier family 7 member 7; y(+)L type amino acid transporter 1; y(+)L-type amino acid transporter 1; Y+L amino acid transporter 1; y+LAT-1; Y+LAT1; YLAT1_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
  • 基因功能參考文獻：
    1. SLC7A7 overexpression decreased the apoptosis rate, increased the proportion of cells in the G1 phase, decreased the proportion of G2 cells, and significantly increased cell migration and invasion and increased intracellular arginine would activate mTOR, and induce apoptosis in SLC7A7 knockdown Jurkat cells. PMID: 30025393
    2. Confirmed by mRNA and protein expression, the amino acid transporters SLC7A7 and SLC38A5 showed marked differences between controls and intrauterine growth restriction/pre-eclampsia and were regulated by both diseases. In contrast, ABCA1 may play an exclusive role in the development of pre-eclempsia. PMID: 29499643
    3. At present, 51 kinds of SLC7A7 gene mutations causing lysinuric protein intolerance have been found worldwide, including insert (C.1384-1385 ins ACTA), delete (C.1185-1188 del TTCT) and point mutations (P.R410X, P.Y457X, P.R 468X, P.L124p, etc).3, 4 In our cases, there were two heterozygous mutations in the SLC7A7 gene of the two sisters: C.1387 del C and IVS4+1C>T, which has never been reported worldwide. PMID: 29058386
    4. The study reports a significant association between SLC7A7 rs12436190 and the risk of glioma in a Chinese population. PMID: 28510245
    5. the 1471 delTTCT mutation was identified in exon 9 in the homozygous state for all Tunisian patients with lysinuric protein Intolerance; The 1471 deITTCT mutation seems to be a common mutation of Tunisian population PMID: 26882824
    6. heteromerization of y+LAT1 and 4F2hc within the cell is not disrupted by any of the tested LPI mutations PMID: 23940088
    7. SLC7A7 genetic variants are associated with increase risk for glioma in a Chinese population. PMID: 23975734
    8. SLC7A7 plays a critical role in glioblastoma carcinogenesis and overexpression of SLC7A7 is correlated with worse outcomes in patients PMID: 23408368
    9. SLC7A7/y+LAT1 mutations lead to a defective phenotype of macrophages resulting in lysinuric Protein Intolerance. PMID: 22325938
    10. during differentiation of human monocytes from peripheral blood, SLC7A7 mRNA and system y(+)L activity are increased PMID: 21586674
    11. novel SLC7A7 mutations in patients with lysinuric protein intolerance PMID: 12402335
    12. expression levels and putative 5' promoter elements of the SLC7A7 gene PMID: 12589791
    13. putative multiheteromeric structure of both [4F2hc/y(+)LAT-1] and [4F2hc/y(+)LAT-2], and the interference between y(+)LAT-1 and y(+)LAT-2 proteins may have a role in the pathogenesis of lysinuric protein intolerance PMID: 15756301
    14. mutations of the SLC7A7 gene may have a role in lysinuric protein intolerance PMID: 15776427
    15. identified a novel alternative, TATA-box-containing promoter that plays a role in the tissue-specific regulation of SLC7A7 gene expression PMID: 17196863
    16. Mutation in the SLC7A7 gene is associated with lysinuric protein intolerance PMID: 17666782
    17. A review of the current knowledge of SLC7A7 mutations and their role in LPI pathogenesis. PMID: 17764084
    18. results suggest genomic rearrangement of SLC7A7 play more important role in lysinuric protein intolerance than has been reported; 3' region AluY repeat could be a recombination hot spot as it is involved in 38% of SLC7A7 rearranged chromosomes described PMID: 18716612

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  • 相關疾病：
    Lysinuric protein intolerance (LPI)
  • 亞細胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
  • 組織特異性：
    Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, ret
  • 數據庫鏈接：

    HGNC: 11065

    OMIM: 222700

    KEGG: hsa:9056

    STRING: 9606.ENSP00000285850

    UniGene: Hs.513147



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