在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC7A7 Antibody, FITC conjugated

  • 中文名稱:
    SLC7A7兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA892349LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC7A7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC7A7
  • 別名:
    LAT3 antibody; LPI antibody; Monocyte amino acid permease 2 antibody; MOP-2 antibody; MOP2 antibody; SLC7A 7 antibody; Slc7a7 antibody; Solute carrier family 7 (cationic amino acid transporter; y+ system); member 7 antibody; Solute carrier family 7 member 7 antibody; y(+)L type amino acid transporter 1 antibody; y(+)L-type amino acid transporter 1 antibody; Y+L amino acid transporter 1 antibody; y+LAT-1 antibody; Y+LAT1 antibody; YLAT1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Y+L amino acid transporter 1 protein (325-382AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
  • 基因功能參考文獻:
    1. SLC7A7 overexpression decreased the apoptosis rate, increased the proportion of cells in the G1 phase, decreased the proportion of G2 cells, and significantly increased cell migration and invasion and increased intracellular arginine would activate mTOR, and induce apoptosis in SLC7A7 knockdown Jurkat cells. PMID: 30025393
    2. Confirmed by mRNA and protein expression, the amino acid transporters SLC7A7 and SLC38A5 showed marked differences between controls and intrauterine growth restriction/pre-eclampsia and were regulated by both diseases. In contrast, ABCA1 may play an exclusive role in the development of pre-eclempsia. PMID: 29499643
    3. At present, 51 kinds of SLC7A7 gene mutations causing lysinuric protein intolerance have been found worldwide, including insert (C.1384-1385 ins ACTA), delete (C.1185-1188 del TTCT) and point mutations (P.R410X, P.Y457X, P.R 468X, P.L124p, etc).3, 4 In our cases, there were two heterozygous mutations in the SLC7A7 gene of the two sisters: C.1387 del C and IVS4+1C>T, which has never been reported worldwide. PMID: 29058386
    4. The study reports a significant association between SLC7A7 rs12436190 and the risk of glioma in a Chinese population. PMID: 28510245
    5. the 1471 delTTCT mutation was identified in exon 9 in the homozygous state for all Tunisian patients with lysinuric protein Intolerance; The 1471 deITTCT mutation seems to be a common mutation of Tunisian population PMID: 26882824
    6. heteromerization of y+LAT1 and 4F2hc within the cell is not disrupted by any of the tested LPI mutations PMID: 23940088
    7. SLC7A7 genetic variants are associated with increase risk for glioma in a Chinese population. PMID: 23975734
    8. SLC7A7 plays a critical role in glioblastoma carcinogenesis and overexpression of SLC7A7 is correlated with worse outcomes in patients PMID: 23408368
    9. SLC7A7/y+LAT1 mutations lead to a defective phenotype of macrophages resulting in lysinuric Protein Intolerance. PMID: 22325938
    10. during differentiation of human monocytes from peripheral blood, SLC7A7 mRNA and system y(+)L activity are increased PMID: 21586674
    11. novel SLC7A7 mutations in patients with lysinuric protein intolerance PMID: 12402335
    12. expression levels and putative 5' promoter elements of the SLC7A7 gene PMID: 12589791
    13. putative multiheteromeric structure of both [4F2hc/y(+)LAT-1] and [4F2hc/y(+)LAT-2], and the interference between y(+)LAT-1 and y(+)LAT-2 proteins may have a role in the pathogenesis of lysinuric protein intolerance PMID: 15756301
    14. mutations of the SLC7A7 gene may have a role in lysinuric protein intolerance PMID: 15776427
    15. identified a novel alternative, TATA-box-containing promoter that plays a role in the tissue-specific regulation of SLC7A7 gene expression PMID: 17196863
    16. Mutation in the SLC7A7 gene is associated with lysinuric protein intolerance PMID: 17666782
    17. A review of the current knowledge of SLC7A7 mutations and their role in LPI pathogenesis. PMID: 17764084
    18. results suggest genomic rearrangement of SLC7A7 play more important role in lysinuric protein intolerance than has been reported; 3' region AluY repeat could be a recombination hot spot as it is involved in 38% of SLC7A7 rearranged chromosomes described PMID: 18716612

    顯示更多

    收起更多

  • 相關疾病:
    Lysinuric protein intolerance (LPI)
  • 亞細胞定位:
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
  • 組織特異性:
    Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, ret
  • 數據庫鏈接:

    HGNC: 11065

    OMIM: 222700

    KEGG: hsa:9056

    STRING: 9606.ENSP00000285850

    UniGene: Hs.513147



主站蜘蛛池模板: 中文字幕av伊人av无码av狼人| 日日噜噜噜噜夜夜爽亚洲精品| 日本免费一区二区三区中文字幕| 国产亚洲精品久久久久久无几年桃| 久久久国产精品麻豆a片| 人妻三级日本香港三级极97| 熟妇人妻系列av无码一区二区| 少妇人妻邻居| 亚洲s码欧洲m码国产av| 欧美 国产 亚洲视频| 久久人人爽人人爽爽久久小说| 国产亚洲精品欧洲在线观看| 欧美老熟妇乱子伦视频| 中文字幕日本人妻久久久免费| 综合图片亚洲综合网站| 亚洲爆乳成av人在线视菜奈实| 无码av无码天堂资源网影音先锋 | 高清国产亚洲欧洲av综合一区| 日韩亚洲国产高清免费视频| 国产精品久久久久久亚洲毛片| 国产99在线 | 中文| 亚洲乱码卡一卡二卡| 最新在线精品国自产拍福利| 无码无套少妇毛多18pxxxx| 亚洲人成精品久久久久| 人人人插人人费| 色综合伊人丁香五月桃花婷婷| 成熟丰满熟妇av无码区| 成 人色 网 站 欧美大片在线观看| 2021国产精品香蕉在线观看| 久久精品亚洲中文无东京热| 国内精品久久毛片一区二区| 亚洲欧美日韩成人综合网| 久久国国产免费999| 波多野结衣不打码视频| 无翼乌工口肉肉无遮挡无码18| 国产精品sm捆绑调教视频| 国产精品av一区二区三区不卡蜜| 国产精品h片在线播放| 人人妻一区二区三区| 国产男女嘿咻视频在线观看|