在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Wings apart-like protein homolog (WAPAL), partial

  • 中文名稱:
    人WAPL重組蛋白
  • 貨號:
    CSB-YP772025HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人WAPL重組蛋白
  • 貨號:
    CSB-EP772025HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人WAPL重組蛋白
  • 貨號:
    CSB-EP772025HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人WAPL重組蛋白
  • 貨號:
    CSB-BP772025HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人WAPL重組蛋白
  • 貨號:
    CSB-MP772025HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    WAPL
  • Uniprot No.:
  • 別名:
    FOE; Friend of EBNA2 (Epstein Barr virus nuclear protein 2); Friend of EBNA2 protein; KIAA0261; OTTHUMP00000020004; WAPAL; WAPL; WAPL_HUMAN; Wings apart like homolog; Wings apart like homolog (Drosophila); Wings apart-like protein homolog
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
  • 基因功能參考文獻:
    1. Study shows that chromatin loop size can be increased and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged. Cohesin's DNA release factor WAPL restricts this loop extension and also prevents looping between incorrectly oriented CTCF sites. PMID: 28475897
    2. Rs7083506 and rs11202058 polymorphisms of hWAPL and their haplotype T-A were associated with cervical cancer. PMID: 26722608
    3. WAPL-depleted cells undergo anaphase with segregation errors, resulting in micronuclei and DNA damage. Stable WAPL depletion arrests cells in a p53-dependent manner but causes p53-deficient cells to become highly aneuploid. PMID: 24055153
    4. Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin PMID: 23776203
    5. Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21-deficient or Scc1 mutant-expressing cells PMID: 22751501
    6. FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain. PMID: 15383329
    7. Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits PMID: 17112726
    8. Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin. PMID: 17113138
    9. our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability. PMID: 17382297
    10. isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder. PMID: 18662753

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 2]: Nucleus.; Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
  • 蛋白家族:
    WAPL family
  • 組織特異性:
    Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
  • 數據庫鏈接:

    HGNC: 23293

    OMIM: 610754

    KEGG: hsa:23063

    STRING: 9606.ENSP00000298767

    UniGene: Hs.203099



主站蜘蛛池模板: 黄网站欧美内射| 国产清纯白嫩初高生在线观看| 中文字字幕在线中文乱码| 伊人色综合网一区二区三区| 欧美中文字幕无线码视频| 亚洲国产品综合人成综合网站 | 桃花综合久久久久久久久久网| 国产午睡沙发被弄醒完整版| 最新亚洲中文av在线不卡| 乌克兰少妇xxxx做受| 国产乱人偷精品人妻a片| 色综合99久久久无码国产精品| 四虎永久在线精品免费视频观看| 久久久www成人免费看片| 久久久久久综合岛国免费观看| 亚洲中文字幕无码久久 | 久久精品国产2020| 青青草原综合久久大伊人精品| 牛牛在线视频| 久久午夜无码鲁丝片秋霞| 人妻少妇伦在线麻豆m电影| 午夜免费啪在线观看视频| 揉着我的奶从后面进去视频| 欧美老熟妇乱大交xxxxx| 国产精品老熟女露脸视频| 亚洲制服丝中文字幕| 欧洲精品卡一卡二卡三| 少妇激情一区二区三区视频小说| 97se亚洲国产综合在线| 天天天天做夜夜夜夜做无码| 亚洲欧洲日产国码无码网站| 国产激情一区二区三区| 人妻少妇精品视频一区二区三区| 中国国产野外1级毛片视频| 在线资源天堂www| 欧美日韩国产精品| 久久五月精品中文字幕| 四虎成人永久在线精品免费| 精品国产乱码久久久软件下载| 久久精品噜噜噜成人av| 青娱乐极品视觉盛宴国产视频 |