在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WAPL Antibody, Biotin conjugated

  • 中文名稱:
    WAPL兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA772025LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) WAPL Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WAPL
  • 別名:
    FOE antibody; Friend of EBNA2 (Epstein Barr virus nuclear protein 2) antibody; Friend of EBNA2 protein antibody; KIAA0261 antibody; OTTHUMP00000020004 antibody; WAPAL antibody; WAPL antibody; WAPL_HUMAN antibody; Wings apart like homolog antibody; Wings apart like homolog (Drosophila) antibody; Wings apart-like protein homolog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Wings apart-like protein homolog protein (1037-1190AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
  • 基因功能參考文獻:
    1. Study shows that chromatin loop size can be increased and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged. Cohesin's DNA release factor WAPL restricts this loop extension and also prevents looping between incorrectly oriented CTCF sites. PMID: 28475897
    2. Rs7083506 and rs11202058 polymorphisms of hWAPL and their haplotype T-A were associated with cervical cancer. PMID: 26722608
    3. WAPL-depleted cells undergo anaphase with segregation errors, resulting in micronuclei and DNA damage. Stable WAPL depletion arrests cells in a p53-dependent manner but causes p53-deficient cells to become highly aneuploid. PMID: 24055153
    4. Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin PMID: 23776203
    5. Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21-deficient or Scc1 mutant-expressing cells PMID: 22751501
    6. FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain. PMID: 15383329
    7. Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits PMID: 17112726
    8. Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin. PMID: 17113138
    9. our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability. PMID: 17382297
    10. isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder. PMID: 18662753

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 2]: Nucleus.; Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
  • 蛋白家族:
    WAPL family
  • 組織特異性:
    Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
  • 數據庫鏈接:

    HGNC: 23293

    OMIM: 610754

    KEGG: hsa:23063

    STRING: 9606.ENSP00000298767

    UniGene: Hs.203099



主站蜘蛛池模板: 国产清纯美女爆白浆视频| 亚洲精品久久午夜无码一区二区 | 欧美另类videosbestsex日本 | 亚洲天天做日日做天天欢毛片| 国内精品久久久久久久久齐齐| 色偷偷色噜噜狠狠成人免费视频| 久久久久久夜精品精品免费啦| 精品久久久久久777米琪桃花| 精品无码中文视频在线观看| 精品人妻va出轨中文字幕| 欧美亚洲国产手机在线有码| 亚洲精品日韩一区二区电影| 欧美大屁股熟妇bbbbbb| 国产免费人成网站x8x8| 国产极品白嫩精品| 亚洲国产欧美国产综合一区| 日本熟妇乱人伦a片免费高清| 久久只有这里有精品4| 成人av在线一区二区三区| 精品国产乱码久久久久软件| 小说区 图片区色 综合区| 亚洲成av人片一区二区三区| 牲高潮99爽久久久久777| 妖精色av无码国产在线看| 国产激情久久久久影院老熟女免费 | 中文字幕精品久久久乱码乱码| 午夜亚洲www湿好爽| 精选国产av精选一区二区三区| 天天爱天天做久久狠狠做| 法国啄木乌av片在线播放| 美女露全乳无遮掩视频| 午夜精品久久久久久久喷水| 中文字幕人妻丝袜成熟乱| 国产农村黄aaaaa特黄av毛片 | 日韩va中文字幕无码电影| 国产真实夫妇视频| 好男人在线社区www在线影院| 日日碰狠狠躁久久躁9| 国产一区二区三区四区精华| 成 人 综合 亚洲另类| 中文韩国午夜理伦三级好看|