在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WAPL Antibody, HRP conjugated

  • 中文名稱:
    WAPL兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA772025LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) WAPL Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WAPL
  • 別名:
    FOE antibody; Friend of EBNA2 (Epstein Barr virus nuclear protein 2) antibody; Friend of EBNA2 protein antibody; KIAA0261 antibody; OTTHUMP00000020004 antibody; WAPAL antibody; WAPL antibody; WAPL_HUMAN antibody; Wings apart like homolog antibody; Wings apart like homolog (Drosophila) antibody; Wings apart-like protein homolog antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Wings apart-like protein homolog protein (1037-1190AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
  • 基因功能參考文獻:
    1. Study shows that chromatin loop size can be increased and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged. Cohesin's DNA release factor WAPL restricts this loop extension and also prevents looping between incorrectly oriented CTCF sites. PMID: 28475897
    2. Rs7083506 and rs11202058 polymorphisms of hWAPL and their haplotype T-A were associated with cervical cancer. PMID: 26722608
    3. WAPL-depleted cells undergo anaphase with segregation errors, resulting in micronuclei and DNA damage. Stable WAPL depletion arrests cells in a p53-dependent manner but causes p53-deficient cells to become highly aneuploid. PMID: 24055153
    4. Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin PMID: 23776203
    5. Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21-deficient or Scc1 mutant-expressing cells PMID: 22751501
    6. FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain. PMID: 15383329
    7. Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits PMID: 17112726
    8. Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin. PMID: 17113138
    9. our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability. PMID: 17382297
    10. isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder. PMID: 18662753

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 2]: Nucleus.; Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
  • 蛋白家族:
    WAPL family
  • 組織特異性:
    Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 23293

    OMIM: 610754

    KEGG: hsa:23063

    STRING: 9606.ENSP00000298767

    UniGene: Hs.203099



主站蜘蛛池模板: 国产精品久久久久久超碰| 色视频综合无码一区二区三区| 中文字幕亚洲码在线| 农民人伦一区二区三区| 99久久精品国产一区二区三区| 学生精品国产在线视频| 亚洲性夜色噜噜噜在线观看不卡| 人妻av中文字幕久久| 亚洲成熟女人毛毛耸耸多| 国产av一区二区精品凹凸| 成人av一本不卡二卡| 国产午夜成人久久无码一区二区| 亚洲午夜精品a片久久www慈禧| 午夜福利18以下勿进免费| 日韩视频 中文字幕 视频一区| 天天摸日日摸狠狠添| 成在人线av无码免费看| 999成人精品视频在线| 人人人妻人人人妻人人人| 成熟了的熟妇毛茸茸| 亚洲国产欧美一区点击进入| 久久天天躁夜夜躁狠狠躁| 国产suv精品一区二区| 国产成人无码免费视频在线 | 色播在线精品一区二区三区四区| 日韩人妻少妇一区二区| 欧美黑人又大又粗xxxxx| 成人区精品一区二区不卡| 国产成av人片久青草影院| 亚洲码欧美码一区二区三区| 久久国产avjust麻豆| 国产成人免费永久播放视频平台| 野外做受又硬又粗又大视频√| 日本体内she精高潮| 成人国产精品无码网站| 午夜毛片不卡高清免费看 | 免费无码不卡视频在线观看| 亚洲旡码a∨一区二区三区| 朝鲜女子内射杂交bbw| 国产乱人伦偷精品视频| 8x福利精品第一导航|