在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Urocortin-3 (UCN3)

In Stock
  • 中文名稱:
    人UCN3重組蛋白
  • 貨號:
    CSB-EP846570HUa2
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    UCN3
  • Uniprot No.:
  • 別名:
    (Stresscopin)(Urocortin III)(Ucn III)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    17.7 kDa
  • 表達區域:
    119-161aa
  • 氨基酸序列
    KFTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQIGRKK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
  • 基因功能參考文獻:
    1. Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3 PMID: 27262310
    2. In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients. PMID: 27754786
    3. circulating levels elevated and positively correlated with C-reactive protein in polycystic ovary syndrome PMID: 26488073
    4. results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway PMID: 26350463
    5. The paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin release to ensure the timely reduction of insulin secretion upon normalization of plasma glucose. PMID: 26076035
    6. The molecular modifications of urocortin 3[36-38] led to an improved understanding of the relationship between molecular structure and biological activity of this peptide, could be further tested for possible clinical treatment of depression PMID: 25304878
    7. Data suggest that UCN3 expression can serve as a late stage maturation/differentiation marker in beta-cells during pancreogenesis. [REVIEW] PMID: 25148370
    8. SCP inhibits a subpopulation of PVN neurons, especially OTergic magnocellular neurons, by enhancing the activity of GIRK channels via CRF-R2 PMID: 23349753
    9. study showed that Ucn2 and Ucn3 differentially regulate the LPS-induced TNF-alpha and IL-10 expression and secretion in trophoblast explants acting through CRH-R2. Ucn3 has an anti-inflammatory effect. PMID: 22000474
    10. CRH-R1:CRH-R2 ratio varied according to fat-depot type; whereas CRH-R1 expression was higher in sc fat than in visceral fat, the opposite was true for CRH-R2. PMID: 14764822
    11. Expression of Ucn III/SCP in the human heart and kidney as well as brain and pituitary tissues and its presence in plasma and urine. Ucn III/SCP may therefore regulate the cardiac and renal function as a local factor and a circulating hormone. PMID: 15070962
    12. Ucn 3 plays some physiological or pathological roles in the modulation of gastrointestinal functions during stressful conditions. PMID: 15949638
    13. Ucn3 is produced in the normal adrenal gland and in adrenal tumors (both adrenocortical tumors and pheochromocytomas) and acts as an autocrine or paracrine regulator in both the normal and cancerous adrenal gland tissue. PMID: 16095756
    14. the SCP/CRHR2 system is present in human ovaries and treatment with SCP/Ucn3 inhibits progesterone production by cultured granulosa-lutein cells through interaction with CRHR2 PMID: 19351656

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Sauvagine/corticotropin-releasing factor/urotensin I family
  • 數據庫鏈接:

    HGNC: 17781

    OMIM: 605901

    KEGG: hsa:114131

    STRING: 9606.ENSP00000369798

    UniGene: Hs.511775



主站蜘蛛池模板: 水蜜桃亚洲一二三四在线| 国产女人叫床高潮大片| 野外亲子乱子伦视频丶| 国产成人精品久久亚洲高清不卡| av大片在线无码永久免费| 小12萝裸体自慰出白浆| 久久国产精品_国产精品| 中文无码av一区二区三区| 国模裸体无码xxxx视频| 久久99亚洲含羞草影院| 亚洲人成色77777在线观看大战| 性少妇无码播放| yy111111少妇无码理论片| 中文人妻熟妇乱又伦精品| 国产三级精品三级在线专区| 久久丫精品忘忧草西安产品| 国产绳艺sm调教室论坛 | 久久国产乱子伦精品免费午夜| 2020国产欧洲精品网站| 99r在线精品视频在线播放| 亚洲影院丰满少妇中文字幕无码| 鲁鲁鲁爽爽爽在线视频观看| 一群黑人大战亚裔女在线播放| 韩国午夜福利片在线| 天堂…中文在线最新版在线| 久久久久成人精品免费播放动漫| 9九色桋品熟女内射| 亚洲综合区小说区激情区| 97夜夜澡人人爽人人| 欧美牲交40_50a欧美牲交aⅴ| 无码人妻精品一区二区三| 日韩午夜理论免费tv影院| 少妇人妻在线视频| 99久久久无码国产aaa精品| 麻豆熟妇人妻xxxxxx| 亚洲国产成人综合在线不卡| 国产在线视频www色| 国产 在线 | 日韩| 亚洲精品欧美综合一区二区| 夜夜揉揉日日人人| 久久精品国产亚洲精品|