在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Innate immunity activator protein (INAVA)

  • 中文名稱:
    人INAVA重組蛋白
  • 貨號:
    CSB-YP662049HU
  • 規(guī)格:
    ¥1500
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    INAVA
  • Uniprot No.:
  • 別名:
    C1orf106; CA106_HUMAN; Chromosome 1 open reading frame 106 ; FLJ10901; Uncharacterized protein C1orf106
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    65.5kDa
  • 表達(dá)區(qū)域:
    1-578aa
  • 氨基酸序列
    MLQMPKLNEIPPGRAGRREARGEGRWPGQTGPEAARLEWRAQGQAGGARAPWDSWGSSRLPTQPGPGWSRCPPSLLCALSFQKSTMESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRIVRTPSLKDSPAGR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
  • 基因功能參考文獻(xiàn):
    1. C1orf106 regulates adherens junction stability by regulating the degradation of cytohesin-1, a guanine nucleotide exchange factor that controls activation of ARF6. PMID: 29420262
    2. IBD-associated polymorphisms in INAVA modulate PRR-initiated signaling, cytokines, and intracellular bacterial clearance, likely contributing to intestinal immune homeostasis. PMID: 28436939
    3. Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. PMID: 27980695
  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm.
  • 組織特異性:
    Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 25599

    KEGG: hsa:55765

    STRING: 9606.ENSP00000356311

    UniGene: Hs.518997



主站蜘蛛池模板: 日本精品人妻无码免费大全| 人妻丰满熟妇av无码处处不卡 | 久久国产成人午夜av影院| 国产69精品久久久久999小说| 黑巨人与欧美精品一区| 四虎成人永久在线精品免费| 女人高潮抽搐潮喷小视频| 人妻系列无码一区二区三区| 欧美肥老太交性506070| 性xxxx18免费观看视频| 日本伊人色综合网| 尤物yw午夜国产精品大臿蕉| 国产乱人伦av在线a最新| 亚洲五月丁香综合视频| 女的被弄到高潮娇喘喷水视频| 成人做爰100部片免费下载| 学生妹无套内射正在播放| 日韩欧美亚洲中文乱码| 久久人人97超碰国产公开| 国产激情久久久久久熟女老人| 亚洲午夜性猛春交xxxx| 国产九九99久久99大香伊| 亚洲妇女自偷自偷图片| 日本在线视频www鲁啊鲁| 色一情一区二区三区四区| 一本久久综合亚洲鲁鲁五月天| 亚洲 日韩 欧美 成人 在线| 天天狠天天添日日拍| 免费无码又爽又刺激网站| 人妻人人做人做人人爱| 久久综合色一综合色88| 国产成人免费高清直播| 女人被男人躁得好爽免费视频| 亚洲aⅴ无码成人网站国产app| 国产精品无码mv在线观看| 日本国产成人国产在线播放| 天天天狠天天碰天天爱| 波多野美乳人妻hd电影欧美| 久久99精品国产99久久6尤物| 国产亚洲精品福利视频在线观看| 亚洲欧美日韩v在线观看不卡|