在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Innate immunity activator protein (INAVA)

Recombinant Human Innate immunity activator protein (INAVA)

  • 中文名稱：
    Recombinant Human Innate immunity activator protein(INAVA)
  • 貨號：
    CSB-EP662049HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Innate immunity activator protein(INAVA)
  • 貨號：
    CSB-EP662049HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Innate immunity activator protein(INAVA)
  • 貨號：
    CSB-BP662049HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Innate immunity activator protein(INAVA)
  • 貨號：
    CSB-MP662049HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    C1orf106
  • Uniprot No.：
  • 別名：
    C1orf106; CA106_HUMAN; Chromosome 1 open reading frame 106 ; FLJ10901; Uncharacterized protein C1orf106
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length
  • 表達區(qū)域：
    1-578aa
  • 氨基酸序列
    MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRIVRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFGRALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
  • 基因功能參考文獻：
    1. C1orf106 regulates adherens junction stability by regulating the degradation of cytohesin-1, a guanine nucleotide exchange factor that controls activation of ARF6. PMID: 29420262
    2. IBD-associated polymorphisms in INAVA modulate PRR-initiated signaling, cytokines, and intracellular bacterial clearance, likely contributing to intestinal immune homeostasis. PMID: 28436939
    3. Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. PMID: 27980695
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25599

    KEGG: hsa:55765

    STRING: 9606.ENSP00000356311

    UniGene: Hs.518997



主站蜘蛛池模板： 丁香色婷婷国产精品视频| 日本欧美视频在线观看| 欧美人妻一区二区三区| 天天干天天日| 国产精品jk白丝在线播放| 免费看小12萝裸体视频国产| 免费播放婬乱男女婬视频国产 | 亚洲色精品三区二区一区| 亚洲熟妇丰满多毛xxxx| 99精品无人区乱码在线观看| 亚洲精品卡2卡3卡4卡5卡区| 夜精品一区二区无码a片| 色香欲综合成人免费视频| 无码国产精品一区二区免费式芒果| 国产无套内射又大又猛又粗又爽| 国产毛片不卡野外视频| 国产 制服丝袜 动漫在线| 在线看片人成视频免费无遮挡| 丰满多毛的大隂户毛茸茸| 99视频精品全部免费免费观看| av无码久久久久不卡网站蜜桃 | 亚洲色大成网站www久久九九| 娇妻玩4p被三个男人伺候电影| 丁香五月亚洲综合深深爱| 精品国产肉丝袜久久| 玩弄白嫩少妇xxxxx性| 国产内射老熟女aaaa∵| 欧洲丰满少妇a毛片| 人人爽人人爽人人爽| 亚洲色成人网站www永久四虎 | 午夜dv内射一区二区| 男女性杂交内射女bbwxz| 青草精品国产福利在线视频| 韩国主播av福利一区二区| 中文字幕人成无码人妻综合社区| 国产动作大片中文字幕| 国产精品成人一区二区不卡| 亚洲中文字幕无码av在线| 人人做人人爽人人爱| 香港特级三a毛片免费观看| 国产精品一区二区高清在线|