在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Innate immunity activator protein (INAVA)

Recombinant Human Innate immunity activator protein (INAVA)

  • 中文名稱：
    Recombinant Human Innate immunity activator protein(INAVA)
  • 貨號：
    CSB-EP662049HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Innate immunity activator protein(INAVA)
  • 貨號：
    CSB-EP662049HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Innate immunity activator protein(INAVA)
  • 貨號：
    CSB-BP662049HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Innate immunity activator protein(INAVA)
  • 貨號：
    CSB-MP662049HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    C1orf106
  • Uniprot No.：
  • 別名：
    C1orf106; CA106_HUMAN; Chromosome 1 open reading frame 106 ; FLJ10901; Uncharacterized protein C1orf106
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length
  • 表達區(qū)域：
    1-578aa
  • 氨基酸序列
    MESKDEVSDTDSGIILQSGPDSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHREDPLSSLERQLALQLQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNSEPPPAAALPLGRELSASDDSSLSDGLLLEEEESQVPKPPPESPAPPSRPLPPQTLEGLQPTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEPASYHVVPIRGVPGQWQGRTSAPATPEIQGRRGQSQSLRVDSFRAGPEGRGRSAFPRRRPTHYTVTVPDSCFPATKPPLPHAACHSCSEDSGSDVSSISHPTSPGSSSPDISFLQPLSPPKTHRHRGAWVPAGSRELVAHHPKLLLPPGYFPAGRYVVVAESPLPPGEWELRRAAPGPAYEEEGTPLRYQRLVPSRSRIVRTPSLKDSPAGRGLSKAAVSEELKWWHERARLRSTRPHSLDRQGAFRVRSLPLGREGFGRALGPRAQVPTVCVLRRSPDGAPVQVFVPEKGEIISQV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
  • 基因功能參考文獻：
    1. C1orf106 regulates adherens junction stability by regulating the degradation of cytohesin-1, a guanine nucleotide exchange factor that controls activation of ARF6. PMID: 29420262
    2. IBD-associated polymorphisms in INAVA modulate PRR-initiated signaling, cytokines, and intracellular bacterial clearance, likely contributing to intestinal immune homeostasis. PMID: 28436939
    3. Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. PMID: 27980695
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25599

    KEGG: hsa:55765

    STRING: 9606.ENSP00000356311

    UniGene: Hs.518997



主站蜘蛛池模板： 午夜福利视频合集1000| 无码av永久免费专区麻豆| 真人抽搐一进一出视频| 欧美成人午夜免费全部完| 老司机久久精品最新免费| 免费无码又爽又刺激成人| 国产熟女高潮视频| 真人性囗交69视频| 狠狠做深爱婷婷久久综合一区| 国产在线无码播放不卡视频 | 亚洲国产无套无码av电影| 丰满人妻一区二区三区无码av| 国产高清视频在线观看69| 国产成人综合久久免费导航| 国产精品人成视频免费999| 国产又爽又黄无码无遮挡在线观看 | 亚洲无线码一区二区三区| 久久午夜伦鲁片免费无码| 女人爽到高潮免费视频大全 | 97超碰国产精品无码分类| 午夜福利av无码一区二区| 成人性做爰aaa片免费| 精品人伦一区二区三区潘金莲| 粗壮挺进人妻水蜜桃成熟漫画| 国产乱码一区二区三区爽爽爽| 中文无码乱人伦中文视频在线| 天天做天天爱天天综合网| 亚洲无日韩码精品| 欧美日本日韩| 日本55丰满熟妇厨房伦| 久草热8精品视频在线观看| 亚洲人成黄网站69影院| 女人高潮内射99精品| 国产香港明星裸体xxxx视频| 天堂中文资源库官网| 九九精品无码专区免费| 99国产精品久久久久久久成人 | 亚洲一卡一卡二新区无人区| 久久www成人片免费看| 久久久久国产精品免费免费搜索| 国产男女无遮挡猛进猛出|